The Importance of CoQ10
By: Bruce Brightman
Founder LifeSource Vitamins
The difference between ubiquinone and ubiquinol
New case study on ubiquinol report
CoQ10 is an ideal nutrient for all of us. It affects our energy and
longevity, heart health, blood pressure, brain, gums, stomach, immune
system, and much more. It is an enzyme found in almost all cells in the
body, where it helps with the production of energy within the mitochondria.
There is evidence that it can increase the volume of oxygen in the blood by
as much as 15%.
Our cells require CoQ10 to function properly and without it, the cells
perish. It is a strong anti-oxidant in both mitochondria and lipid
membranes. CoQ10 is located exactly where the free-radicals are generated
(in the mitochondria) during the oxidation of nutrients and the production
of ATP, making it an important factor in slowing the aging process.
CoQ10 was discovered in 1957 at the University of Wisconsin-Madison Enzyme
Institute by Fred L. Crane and colleagues. Since 1960, universities and
researchers have published over 1,600 articles in medical journals
demonstrating CoQ10's benefits and importance. In 1978, Peter D. Mitchell
won the Nobel Prize for Chemistry for his discovery of the significance of
CoQ10 in energy production.
The organs with the highest CoQ10 concentration are the heart, lungs and
liver. Ninety-five percent of our body's energy requirements require the
aid of CoQ10. CoQ10 is heavily concentrated in the heart where it benefits
cardiovascular function (see the case study below). CoQ10 has been an aid
to people with high blood pressure, peptic ulcers, periodontal disease,
migraine headaches, muscular dystrophy, and of course heart disease. CoQ10
also aids in slowing down the aging process, stimulating the immune system
and protecting brain cells. As we age, the dopamine production within the
brain decreases, impairing our memories and movement.
The major benefits of CoQ10 and its importance to general health.
CoQ10 now comes in two forms: ubiquinone and ubiquinol. Ubiquinone is the
product most familiar to everyone since it has been available in the
marketplace for a long time and research has shown its benefits.
Ubiquinone is converted within our body into ubiquinol, the potent
anti-oxidant portion of CoQ10. However, as we age, our ability to make this
conversion reduces significantly. Therein lies the major difference between
the two products. Ubiquinol is already in its reduced form as a potent
anti-oxidant. Ubiquinol inhibits protein and lipid oxidation in cell
membranes, and helps to minimize oxidative injury to DNA. So what
significance does this have for us? Here is a recent case study received by
Kaneka, the manufacturer of natural pharmaceutical grade ubiquinol and
A 65-year old gentleman with advanced ischemic cardiomyopathy was on
maximal medical therapy. In June of 2006, he had low heart function and
was receiving 450mg of a soybean oil-based CoQ10 that revealed a level
that was sub-therapeutic. He was then given the ubiquinol formulation
at exactly the same dosage of 450mg per day. Three months later, in
September of 2006, his CoQ10 level had increased dramatically. Further
tests one month later showed a dramatic improvement in heart function
and he no longer required any diuretics. By January of 2007, his
improvement was great enough that he became quite active and required
no further hospitalizations. The case study ended with the physician
stating: "This single case represents very striking improvement that I
have not seen before in 25 years of cardiology practice...We have now
repeated and are continuing to treat several other patients with
end-stage or far advanced congestive heart failure with similar
This study demonstrates the importance of using ubiquinol, especially as we
age. Keep in mind there is every indication that the ubiquinone form has
benefits other than those of ubiquinol. To take full advantage of the
benefits of CoQ10, the dosage should include both forms and then according
to age as to which one you take the most. Also, as demonstrated, ubiquinol
does not require the high amount needed by ubiquinone to gain the same
therapeutic effect for certain conditions.
CoQ10 is very safe for healthy individuals. However, if you are on diabetic
medications, diuretics, insulin, ACE inhibitors, Beta Blockers, calcium
channel blockers, HMG Co-A Reductase Inhibitors, Anticoagulants, or
Dopamine-enhancing drugs, check with your doctor. CoQ10's benefits may
require changing dosages of these drugs. Also, check with your health care
provider if you are pregnant or you are giving this to a child.
CoQ10 levels can also be reduced by other nutrients, such as high amounts
of fish oil or pharmaceutical statins. You should check with your health
care provider regarding the dosage. It could go as high as 2,000mg of
ubiquinone or a smaller amount of ubiquinol. A standard dosage appears to
be recommended in the literature as 200mg. My suggestion is to take 100mg
of ubiquinone and 100mg of ubiquinol to gain the benefits of both. An
article published in January, 2007 in the journal CNS Spectrums by Dr.
Young from Duke University suggested that safe levels of CoQ10 are between
300mg to 2,400mg a day.
In just 50 years we've learned so much about this amazing nutrient. Just
think how much there is yet to discover in this remarkable field of
Bruce Brightman - founder
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