LifeSource Vitamins Ultra Beta-Glucan with Maitake Extract — Supports Normal Immune Cell Activity*

Beta-glucans (especially β-1,3/1,6 from yeast and mushrooms) are biological response modulators that interact with innate immune receptors (e.g., dectin-1, CR3), helping prime macrophages, neutrophils, dendritic cells, and NK cells for a balanced response.* Reviews describe receptor recognition and downstream effects on cytokines and adaptive immunity. (NIH/PMC — Zhong X, 2023; NIH/PMC — Castro E, 2020)

Maitake (Grifola frondosa) provides polysaccharide fractions (e.g., D-fraction) investigated for immune-enhancing activity and NK-cell support in early human and translational studies; generally well-tolerated when used appropriately.* Not a treatment; evidence is evolving. (NIH/PubMed — Kodama N, 2003; NIH/PMC — Konno S, 2014; NCI PDQ — 2024)

Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from 39 leading health organizations and insights from 20 top global universities to ensure our guidance aligns with credible science.*

Clinically Studied Benefits (with research)

• Balanced immune modulation* — **β-glucans** engage dectin-1/CR3 to coordinate innate activation and signaling. (NIH/PMC — Zhong X, 2023; NIH/PMC — Castro E, 2020)

• Innate readiness & surveillance* — Reviews note support for **macrophage** and **NK-cell** activity in healthy adults. (NIH/PMC — Castro E, 2020)

• Maitake NK-cell support (adjunct)* — Early human findings with **D-fraction** reported increased NK activity and clinical parameters (adjunct; not treatment). (NIH/PubMed — Kodama N, 2003)

• Human safety & immune effects* — Contemporary β-1,3/1,6-glucan trials show immunologic shifts with good tolerability in healthy adults. (NIH/PMC — Chen SN, 2023)

• Cytokine balance* — Modulation of IL-6, TNF-α and related mediators described in translational/clinical contexts. (NIH/PMC — Zhong X, 2023)

Additional Studies Showing Promising Benefits*

• Respiratory wellness support* — URTI symptom-severity reductions reported in human trials of **yeast β-1,3/1,6-glucan**. (NIH/PubMed — Dharsono T, 2019; NIH/PubMed — Fuller R, 2017; NIH/PubMed — Nieman DC, 2008)

• Gut microbiome balance* — Natural polysaccharides may act as prebiotics and support beneficial bacteria. (NIH/PMC — Sun CY, 2022)

• Healthy blood-glucose response* — Evidence indicates oat β-glucan added to meals reduces glycaemic and insulinaemic responses (dose/MW dependent). (NIH/PubMed — Zurbau A, 2021)

• Cholesterol support* — Reviews support **oat/barley β-glucans** helping maintain healthy LDL/total cholesterol. (NIH/PubMed — Sima P, 2018; NIH/PMC — Sima P, 2018)

University / Academic Context*

• Innate–adaptive cross-talk* — **Dendritic-cell** engagement by β-glucans helps bridge innate to adaptive responses; outcomes vary by source/standardization. (NIH/PMC — Castro E, 2020)

• Evidence landscape & quality considerations* — Academic/clinical summaries emphasize product standardization and dose in interpreting trial results. (NCI PDQ — 2024)

Global Evidence & Authoritative Reviews*

• NIH Office of Dietary Supplements — Fact sheets on fibers/β-glucans, DRIs & safety context. (NIH/ODS — Fact Sheets)

• NCI PDQ (patient & health-professional) — Evidence summaries for medicinal mushrooms/β-glucans; quality considerations. (NCI PDQ — Patient, 2024; NCI PDQ — HP, 2024)

We monitor research from the world’s leading institutions — including Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge University, Oxford, Stanford, Yale, MIT, the University of Florida, Oregon State University – Linus Pauling Institute, Tufts, Boston University, Cornell, Columbia, and Ohio State — to ensure our guidance remains aligned with credible science.*

Brief Benefit Bullets

• Well-researched **β-1,3/1,6-glucans** for immune modulation*

• **Innate readiness** — macrophage & NK-cell support*

• **Maitake synergy** — D-fraction polysaccharides*

• **Cytokine balance** — coordinated signaling context*

• **Year-round wellness** — daily foundational support*

3rd-party lab tested for identity, potency & purity

See All LifeSource Vitamins Immune Support Products

Suggested Use

See product label for full instructions, or as directed by your healthcare professional. Do not exceed recommended dose. If pregnant, nursing, taking medications, or have a medical condition, consult your physician.*

Product Specifications

• Serving Size — 1 Veg Capsule
• Servings Per Container — 90
• Beta-1,3/1,6-D-Glucan Powder (from Saccharomyces cerevisiae) — 100 mg*
• Maitake Mushroom Powder (Grifola frondosa) — 160 mg*
• Form — Easy-to-swallow vegetarian capsules
• Other Ingredients — Cellulose (capsule), Cellulose Powder, Magnesium Stearate (vegetable source), Silica
• Free From — Not manufactured with wheat, gluten, soy, corn, milk, egg, fish, shellfish or tree nut ingredients (produced in a GMP facility that processes other ingredients containing these allergens). Non-GMO*
• Quality — Third-party tested for identity, potency & purity
• Note — Natural color variation may occur. Store in a cool, dry place after opening.

3rd-Party Testing: Every batch is verified by independent labs for identity, potency, and purity. Click here to see our 3rd-party testing.

LifeSource Vitamins — Proudly American — Since 1992

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Ultra Beta-Glucan with Maitake — immune modulation, innate readiness, NK-cell support; Non-GMO & 3rd-party tested. Clinically Studied Ingredients — NIH/PubMed!*

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