Saw Palmetto Berries come from a small palm tree, which grows in the
southeastern US. It has been used by Native Americans and researched in
Europe and Japan, where it is widely consumed.
STUDIES for SAW PALMETTO:
Benign Prostatic Hyperplasia/ Lower Urinary Tract Symptoms:
Symptomatic benign prostatic hyperplasia (BPH) and lower urinary tract
symptoms (LUTS) secondary to BPH, are common medical conditions in older
men. Forty percent of men 70 years or older have lower urinary tract
symptoms consistent with BPH. Treatment for BPH is to relieve urgency,
frequency, nocturia, and obstructive symptoms. Treatment options include
surgical procedures, pharmaceutical, and phytotherapeutic preparations or
lifestyle modification. Saw palmetto is a dietary supplement widely used to
treat the urinary symptoms of BPH.
A study was done on 44 men aged 45 to 80 with symptomatic BPH. Each
patient was given either an herbal blend of 106 mg of saw palmetto
berry lipoidal extract and other herbs (nettle root, pumpkin seed,
lemon bioflavonoid extract, vitamin A as beta-carotene and other minor
ingredients) or placebo three times a day for 6 months. Saw palmetto
herbal blend for symptomatic BPH resulted in the contraction of
prostatic epithelial tissues, possibly via a non- hormonal mechanism.
No adverse effects were observed. Saw palmetto herbal blend may be a
safe and desirable alternative for men with moderately symptomatic BPH.
A review analyzed 18 randomized controlled trials involving 2,939 men.
The mean study duration was 9 weeks (range 4-48 weeks) and the most
frequently reported dose was 160 mg of saw palmetto 2 times a day,
although studies used different doses and preparations of saw palmetto
in combination with other phytotherapeutic compounds. The review
suggested that saw palmetto improved urologic symptoms and flow
measures. When saw palmetto was compared to finasteride (5 a-reductase
inhibitor), it produced similar improvement in urinary tract symptoms
and urinary flow. In addition, there were fewer adverse treatment
events and cost for treatment was less. Overall, further research is
needed to evaluate the long-term effectiveness and safety of saw
palmetto and to determine its ability to prevent complications from
Fifty men with previously untreated lower urinary tract symptoms (LUTS)
were treated with 160 mg of saw palmetto two times a day for 6 months.
Mean Interated Prostate Symptom Score improved from 19.5 ± 5.5 to 12.5
± 7.0 among the 46 men who completed the study. An improvement in
symptom score of 50% or greater after treatment with saw palmetto for
2, 4, and 6 months was noted in 21%, 30% and 46% of patients,
respectively. There was no significant change in the measures of peak
urinary flow. Overall, saw palmetto was well-tolerated and
significantly improved lower urinary tract symptoms in men with BPH.
Placebo-controlled trials are needed to further evaluate saw palmetto's
A randomized, double-blind, placebo-controlled trial was conducted to
look at the effect of saw palmetto in men with LUTS. Men, 45 years or
older, with an Interated Prostate System Score of > 8 were entered.
Eighty-five men were randomized to receive either saw palmetto or
placebo for 6 months. Mean systems were decreased from 16.7 to 12.3 in
the saw palmetto group compared with 15.8 to 13.6 in the placebo group
(p=0.038). Saw palmetto led to significant improvement in urinary
systems in men with LUTS but had no measurable effect on urinary flow
A case report of a 53-year old male with left petroclavial meningioma had
surgical resection of the tumor. During the procedure, the patient had
brisk bleeding that was difficult to control. Later, it was discovered that
the patient had been using saw palmetto for benign prostate hypertrophy.
The prolonged bleeding time in this patient may have been a result of
platelet dysfunction caused by cyclooxygenase inhibition from saw palmetto.
Treatment for prostate cancer is hormonal or androgen-ablative therapy
which induces apoptosis in androgen-dependent prostate cancer cells.
Hormonal therapy is 70 to 80% effective, but most tumors progress to
androgen-independent tumors. These tumors are resistant to androgen
withdrawal-induced apoptosis due to mutation of androgen receptors in these
cells. Human prostatic carcinoma LNCaP cell line is the most widely used in
vitro model of prostate cancer and their growth is increased by androgen.
Extract from saw palmetto, serenoa repens, may induce a mixed type of cell
death, apoptosis or necrosis in LNCaP cells.
Cell viability was examined in LNCaP cells, an in vitro model for
hormonal therapy-resistant prostatic tumor. Results indicated that
exposure from serenoa repens extract resulted in of LNCaP cell death.
It was demonstrated that the extract from Serenoa repens and
myristoleic acid induces mixed cell death of apoptosis and necrosis in
LNCaP cells. These results suggest that the extract and myristoleic
acid may help develop new tools for the treatment of prostate cancer.
A study used three human urological cancer cell lines, PC-3, LNCaP and
SKRC-1, to investigate the effects of the extract from serenoa repens
on tumor cell invasion. The invasive activity of PC-3 cells exposed to
the extract was significantly suppressed in a dose-dependent manner
while that of LNCap and SKRC-a cell were not altered. Urokinase-type
plasminogen activator (uPA) in PC-3 cells was more strongly suppressed
by the extract as compared to the other two cell lines. It was also
found that purified uPA activity is inhibited by the extract from
Serenoa repens in a dose-dependent manner in vitro, suggesting that the
suppression of PC-3 cell invasion by the extract is based on inhibition
of uPA activity which is necessary for tumor cell invasion. These data
suggested that extract from serenoa repens specifically inhibits the
uPA activity and may, therefore, be useful for the therapeutic
treatment of prostate cancer.
LifeSource Vitamins Saw Palmetto - Prostate - BPH Support, used to treat
men for the urinary symptoms of benign prostatic hyperplasia, may be
helpful in the treatment of prostate cancer and overall prostate health. *
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