Hyaluronic Acid (HA) was first used
commercially in 1942 when Endre Balazs applied for a patent to use it as a
substitute for egg white in bakery products. He went on to become the leading
expert on HA, and made the majority of discoveries concerning HA during the
next 50 years.
What is Hyaluronic acid – why is it so important?*
Hyaluronic acid is a naturally occurring, ubiquitous, safe and non-toxic
chemical (1) that is demonstrating surprising results for addressing
inflammation and pain. Its principal characteristics include viscoelasticity,
high water solubility, extended domain presence in solution and maintenance of
cellular and extracellular homeostasis.*
* Lubricates the joints and ligaments.
Orthopedic surgeons, veterinarians, ophthalmologists, dermatologists, general
surgeons and even dentists use hyaluronic. It hastens and improves the healing
of skin, mucous membranes and bone, and is showing remarkable results when used
as a dietary supplement, particularly for patients with arthritic conditions,
individuals who are in extreme pain and are waiting to endure back surgery to
reduce their suffering, and even to improve the health of the skin. Further, this
ingredient has an extraordinary safety profile. Within the body, it performs and
facilitates innumerable basic and essential functions.*
Hyaluronic acid, a KEY component of collagen, has been called
a “space filler” or support scaffolding for living cells. It makes up much of
the material in between cells and provides structure to various organs, such as
the eyes, joints, and skin.* Hyaluronic acid (HA) is akin to mortar in a brick
wall. It holds the bricks (cells) in place. With progressive aging, Hyaluronic
Acid breaks down and less and less is naturally produced within the body. Just
like mortar is the first component to break down in a brick wall, so collagen
degradation produces most of the overt signs of aging in the human body.
LifeSource Vitamins Arthritis Products, Articles and Studies: Click
Arthritis Conditions and Cures W/ Proven Effective Supplements Study: Click
Comparison: LifeSource’s HA with MSM vs. Conquer HA
LifeSource’s Hyaluronic Acid with MSM compared to the popular Conquer
HA supplement for maintaining healthy joint functions.. Which is right for you?
Please use the following information to help you decide. The following chart
contains supplemental facts for 1 daily serving.
HA w/ MSM
The choice really is easy here!
Hyaluronic acid has been nicknamed by the press as the "key to the
fountain of youth" because it has been noted that at least some people who
ingest a lot of it in their diets tend to live to ripe old ages. ABC News had a
show on a village in Japan and hyaluronic acid entitled, "The Village of
Long Life: Could Hyaluronic Acid Be an Anti-Aging Remedy?"*
As Hyaluronic Acid is present in every tissue of the body;
hyaluronic acid’s importance cannot be underestimated. Retention of water is
one of the most important biological functions of hyaluronic acid, second only
to providing nutrients and removing waste from cells that do not have a direct
blood supply, such as cartilage cells. With a lower than adequate amount of hyaluronic
acid, nutrients cannot be moved into these cells and waste cannot be eliminated
from cells. Hyaluronic acid is sometimes abbreviated as HA. *
Hyaluronic acid is found in the synovial joint fluid, Osteoarthritis is a
disease which the majority of Americans, at some point in their life, suffer
from. Many different forms of treatment have been developed to try to help
people through the pain and discomfort which is associated with osteoarthritis.
One of the newer forms of treatment is the replacement of synovial (joint)
fluid within arthritic joints. This is helpful because, during the progression
of arthritis, this synovial fluid breaks down into smaller units, thereby
decreasing its lubricating and shock absorbing abilities.*
In summary, hyaluronic acid has been found to be beneficial
in osteoarthritic knees. There is no explanation as to why some individuals
react positively when others do not. However, it has been found that 80 to 85%
of individuals who are treated with this series of injections have some amount
of pain relief which lasts anywhere from 9 to 12 months. *
Cartilage is a specialized form of connective tissue. Hyaline cartilage is the
most predominant form of cartilage in the body. It lends strength and
flexibility to the body. A key component of cartilage is hyaluronic acid.
Cartilage is also avascular – with no blood vessels. Nutrients are brought by
the synovial fluid, which is rich in hyaluronic acid to the cartilage, which is
also hyaluronic acid-rich.*
Hyaluronic Acid is also found in the extracellular matrix
(ECM). The ECM is composed of material (fibrous elements, including
glycosaminoglycans) produced by the cells and excreted to the extracellular
space with the tissues. All nutrients and metabolic waste are transported
through the ECM. Hyaluronic acid is a major constituent of the ECM and serves
as an essential structural element of the ECM. Hyaluronic acid locks moisture
into the ECM and hyaluronic acid supports the structural integrity of the extracellular matrix.*
In the skin, the extracellular matrix is composed of
hyaluronic acid and other sulfated GAGs, combined with collagen and elastin.
Large amounts of water are held in the ECM. When elastin is not bathed in
water, it becomes dry and brittle, thus the look of dry, brittle, wrinkled
skin.1 Half-life is defined as the time required for one half of the total amount of a
particular substance to be consumed, broken down, or depleted. The half-life of
hyaluronic acid in the cartilage is 2-3 weeks. But the half-life of hyaluronic
acid in the skin is less than 1 day!*
Hyaluronic acid is present in both the dermis and the
epidermis. 50% of the body’s naturally produced hyaluronic acid that is found
in the epidermis is metabolized and excreted in less than 24 hours. Like
hyaluronic acid produced in the body, hyaluronic acid taken as a nutritional
supplement moisturizes from the dermis to the epidermis - from deeper layers of
the skin to the outer layer. *
The extracellular matrix fills up the space between the skin cells. This makes
the skin soft, smooth and elastic. But as we age, hyaluronic content in the
skin changes due to two separate clinically proven factors.
1. There is a decrease in the synthesis of hyaluronic acid.
2. Recompartmentalization – from the epidermis to the dermis.
Both changes leave the epidermis depleted in hyaluronic acid resulting in
thinning, aging, and decreased moisture in the skin. Hyaluronic acid occurs in abundant amounts in
many of the places people with connective tissue disorders have problems such as
the joints, the eyes, the skin and heart valves. Hyaluronic acid is needed to
cushion and lubricate joints, eyes, skin and heart valves.
People with connective tissue disorders and related features all seem to have
abnormalities of hyaluronic acid. In every study I found that analyzed
hyaluronic acid levels in people with connective tissue disorders or related
disorders, when compared to controls they always had hyaluronic acid
HA is influenced by nutrition and other environmental factors.
Many of the features of premature aging syndromes and connective tissue
disorders are also known to be caused by nutritional deficiencies, and not
surprisingly these are often the same nutritional factors that influence the
manufacture of hyaluronic acid. My theory is that this is not all one big
coincidence. Logically, it is more likely to be a predictable sequence of
causes and effects.*
Hyaluronic acid is being used commercially or experimentally to correct a large
portion of the problems found in connective tissue disorders such as fractures,
eye disorders, poor wound healing, and prematurely wrinkled skin. It would be
highly logical to consider the possibility that hyaluronic acid works to
correct these problems because defects or deficiencies of hyaluronic acid are
what causes these problems in the first place.*
Perhaps controlling or optimizing the environmental factors, such as modifying
one's diet, to optimize hyaluronic acid levels would be helpful in treating many
inherited connective tissue disorders and premature aging syndrome.*
Dr. Gina L. Nick
President, California Naturopathic Doctors Association
Vitamins - Hyaluronic Acid - HA - MSM, inflammation, and pain. Its principal
characteristics include viscoelasticity, high water solubility, cellular
homeostasis, lubrication of joints and ligaments.*
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