Hyaluronic Acid (HA) was first used commercially in 1942 when Endre Balazs
applied for a patent to use it as a substitute for egg white in bakery
products. He went on to become the leading expert on HA, and made the
majority of discoveries concerning HA during the next 50 years.
What is Hyaluronic acid – why is it so important?*
Hyaluronic acid is a naturally occurring, ubiquitous, safe and non-toxic
chemical (1) that is demonstrating surprising results for addressing
inflammation and pain. Its principal characteristics include
viscoelasticity, high water solubility, extended domain presence in
solution and maintenance of cellular and extracellular homeostasis.*
* Lubricates the joints and ligaments.
Orthopedic surgeons, veterinarians, ophthalmologists, dermatologists,
general surgeons and even dentists use hyaluronic. It hastens and improves
the healing of skin, mucous membranes and bone, and is showing remarkable
results when used as a dietary supplement, particularly for patients with
arthritic conditions, individuals who are in extreme pain and are waiting
to endure back surgery to reduce their suffering, and even to improve the
health of the skin. Further, this ingredient has an extraordinary safety
profile. Within the body, it performs and facilitates innumerable basic and
Hyaluronic acid, a KEY component of collagen, has been called a “space
filler” or support scaffolding for living cells. It makes up much of the
material in between cells and provides structure to various organs, such as
the eyes, joints, and skin.* Hyaluronic acid (HA) is akin to mortar in a
brick wall. It holds the bricks (cells) in place. With progressive aging,
Hyaluronic Acid breaks down and less and less is naturally produced within
the body. Just like mortar is the first component to break down in a brick
wall, so collagen degradation produces most of the overt signs of aging in
the human body.
See LifeSource Vitamins Arthritis Products, Articles and Studies:
See Arthritis Conditions and Cures W/ Proven Effective Supplements
Comparison: LifeSource’s HA with MSM vs. Conquer HA
LifeSource’s Hyaluronic Acid with MSM compared to the popular Conquer HA
supplement for maintaining healthy joint functions.. Which is right for
you? Please use the following information to help you decide. The following
chart contains supplemental facts for 1 daily serving.
HA w/ MSM
The choice really is easy here!
Hyaluronic acid has been nicknamed by the press as the "key to the fountain
of youth" because it has been noted that at least some people who ingest a
lot of it in their diets tend to live to ripe old ages. ABC News had a show
on a village in Japan and hyaluronic acid entitled, "The Village of Long
Life: Could Hyaluronic Acid Be an Anti-Aging Remedy?"*
As Hyaluronic Acid is present in every tissue of the body; hyaluronic
acid’s importance cannot be underestimated. Retention of water is one of
the most important biological functions of hyaluronic acid, second only to
providing nutrients and removing waste from cells that do not have a direct
blood supply, such as cartilage cells. With a lower than adequate amount of
hyaluronic acid, nutrients cannot be moved into these cells and waste
cannot be eliminated from cells. Hyaluronic acid is sometimes abbreviated
as HA. *
Hyaluronic acid is found in the synovial joint fluid, Osteoarthritis is a
disease which the majority of Americans, at some point in their life,
suffer from. Many different forms of treatment have been developed to try
to help people through the pain and discomfort which is associated with
osteoarthritis. One of the newer forms of treatment is the replacement of
synovial (joint) fluid within arthritic joints. This is helpful because,
during the progression of arthritis, this synovial fluid breaks down into
smaller units, thereby decreasing its lubricating and shock absorbing
In summary, hyaluronic acid has been found to be beneficial in
osteoarthritic knees. There is no explanation as to why some individuals
react positively when others do not. However, it has been found that 80 to
85% of individuals who are treated with this series of injections have some
amount of pain relief which lasts anywhere from 9 to 12 months. *
Cartilage is a specialized form of connective tissue. Hyaline cartilage is
the most predominant form of cartilage in the body. It lends strength and
flexibility to the body. A key component of cartilage is hyaluronic acid.
Cartilage is also avascular – with no blood vessels. Nutrients are brought
by the synovial fluid, which is rich in hyaluronic acid to the cartilage,
which is also hyaluronic acid-rich.*
Hyaluronic Acid is also found in the extracellular matrix (ECM). The ECM is
composed of material (fibrous elements, including glycosaminoglycans)
produced by the cells and excreted to the extracellular space with the
tissues. All nutrients and metabolic waste are transported through the ECM.
Hyaluronic acid is a major constituent of the ECM and serves as an
essential structural element of the ECM. Hyaluronic acid locks moisture
into the ECM and hyaluronic acid supports the structural integrity of the
In the skin, the extracellular matrix is composed of hyaluronic acid and
other sulfated GAGs, combined with collagen and elastin. Large amounts of
water are held in the ECM. When elastin is not bathed in water, it becomes
dry and brittle, thus the look of dry, brittle, wrinkled skin.1 Half-life
is defined as the time required for one half of the total amount of a
particular substance to be consumed, broken down, or depleted. The
half-life of hyaluronic acid in the cartilage is 2-3 weeks. But the
half-life of hyaluronic acid in the skin is less than 1 day!*
Hyaluronic acid is present in both the dermis and the epidermis. 50% of the
body’s naturally produced hyaluronic acid that is found in the epidermis is
metabolized and excreted in less than 24 hours. Like hyaluronic acid
produced in the body, hyaluronic acid taken as a nutritional supplement
moisturizes from the dermis to the epidermis - from deeper layers of the
skin to the outer layer. *
The extracellular matrix fills up the space between the skin cells. This
makes the skin soft, smooth and elastic. But as we age, hyaluronic content
in the skin changes due to two separate clinically proven factors.
1. There is a decrease in the synthesis of hyaluronic acid.
2. Recompartmentalization – from the epidermis to the dermis.
Both changes leave the epidermis depleted in hyaluronic acid resulting in
thinning, aging, and decreased moisture in the skin. Hyaluronic acid occurs
in abundant amounts in many of the places people with connective tissue
disorders have problems such as the joints, the eyes, the skin and heart
valves. Hyaluronic acid is needed to cushion and lubricate joints, eyes,
skin and heart valves.
People with connective tissue disorders and related features all seem to
have abnormalities of hyaluronic acid. In every study I found that analyzed
hyaluronic acid levels in people with connective tissue disorders or
related disorders, when compared to controls they always had hyaluronic
HA is influenced by nutrition and other environmental factors. Many of the
features of premature aging syndromes and connective tissue disorders are
also known to be caused by nutritional deficiencies, and not surprisingly
these are often the same nutritional factors that influence the manufacture
of hyaluronic acid. My theory is that this is not all one big coincidence.
Logically, it is more likely to be a predictable sequence of causes and
Hyaluronic acid is being used commercially or experimentally to correct a
large portion of the problems found in connective tissue disorders such as
fractures, eye disorders, poor wound healing, and prematurely wrinkled
skin. It would be highly logical to consider the possibility that
hyaluronic acid works to correct these problems because defects or
deficiencies of hyaluronic acid are what causes these problems in the first
Perhaps controlling or optimizing the environmental factors, such as
modifying one's diet, to optimize hyaluronic acid levels would be helpful
in treating many inherited connective tissue disorders and premature aging
Dr. Gina L. Nick
President, California Naturopathic Doctors Association
LifeSource Vitamins - Hyaluronic Acid - HA - MSM, inflammation, and pain.
Its principal characteristics include viscoelasticity, high water
solubility, cellular homeostasis, lubrication of joints and ligaments.*
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