Hyaluronan is a naturally occurring component of many of the body's tissues
and biologic fluids. Chemically speaking, it is the same molecule in all
mammals and has been safely used as a supplement in people for years. There
are no known contraindications, interactions, or side effects associated
with Baxyl supplementation.*
The profound roles of the body's own hyaluronan in healthy joints and
connective tissue function are the basis for using Baxyl. The physical
properties of hyaluronan provide the hydration and moisture retention
necessary to lubricate the joints and tissues, and to initiate cell
proliferation and migration within the body.*
Baxyl was developed for maximum bioavailability and efficacy. It is a safe
and effective oral liquid hyaluronan supplement for the support of joint
health and mobility in humans. Don't just reach for any hyaluronan product
on the store shelf. You deserve better! Unlike most joint supplements that
use processed animal by-products; Baxyl's patent-pending formulation is
microbially synthesized, and therefore 100% vegan. Baxyl is of the highest
quality, and contains no ingredients from China to ensure you are receiving
a safe product that is free of impurities and contaminants.
Baxyl is an effective and convenient way to:
Promote healthy joint mobility and lubrication*
Enhance the maintenance of cartilage and joint tissues*
Support healthy bone formation*
Support the maintenance of smooth skin*
Support tissue health and function in the lining of the stomach,
intestines, and bladder.*
Support vertebrae and spine health*
Enhance ocular health*
THE LIQUID ADVANTAGE
To be compared to Baxyl®, any oral hyaluronan supplement must be
bioavailable (usable by the body), absorbed, AND effective. Firstly,
hyaluronan must be completely hydrated in order to be bioavailable and
absorbed. Secondly, once absorbed it must have the appropriate molecular
characteristics, including molecular weight, to be effective.
Baxyl has been developed as a liquid because of the very nature of
hyaluronan itself. Hyaluronan is among nature's most water-loving
molecules. When dry and exposed to moisture, hyaluronan slowly absorbs up
to 1000 times its weight in water, creating a thick, viscous fluid. If
consumed dry as a tablet, the transit time from ingestion to excretion does
not provide the necessary time for hydration of this incredibly hydrophilic
molecule. Research indicates that little of the high molecular weight dry
forms are absorbed before excretion. While some low molecular weight dry
forms may be hydrated and absorbed during ingestion and digestion, they are
not effective and may actually be detrimental to joint health.
WHICH FORM OF HYALURONAN IS MOST EFFECTIVE?
A collaboration of researchers from Kentucky, Missouri, and Ontario, Canada
believe to have the answer: a new and effective dietary supplement
ingredient called MHB3® Hyaluronan, a special hyaluronan biopolymer that is
taken orally. Pre-clinical and clinical studies indicate MHB3® Hyaluronan
is the first supplement ingredient actually proven to promote healthy
cartilage and enhance joint function. The biomacromolecule hyaluronan is
found throughout the body with high concentrations in synovial fluid and
cartilage. With normal stress and aging, hyaluronan breaks down and
deteriorates more rapidly than it can be restored. Baxyl's MHB3® Hyaluronan
helps replenish the natural hyaluronan in the body which:
Enhances Joint Function*
Promotes Healthy Skin*
Unlike other joint supplement ingredients that use processed animal
by-products, MHB3® Hyaluronan is microbially synthesized and has no Chinese
The most critical difference between Baxyl's MHB3® Hyaluronan and other
joint products is the controlled pre-clinical and clinical testing that
confirms its bioavailability, safety, and efficacy.
In a human clinical trial of Baxyl, Douglas W. Kiburz MD, FAOOS, used the
biopolymer orally with 50 subjects for one month. "I spend most of my
professional time helping people deal with joint health. Because every
patient has different needs, systemically supporting cartilage had
tremendous appeal to me and my subjects," Dr. Kiburz said. "We conducted an
open label study to assess its effectiveness with people. Over 80% of study
participants reported good to excellent results." The physician continued,
"With observations like that, MHB3® based products will make glucosamine
and other joint supplements obsolete." The clinical trial also concluded
that the use of MHB3® is safe, having produced no side effects, or apparent
Baxyl is a patented and effective way to promote healthy joint mobility and
lubrication, enhance the maintenance of cartilage and joint tissues,
support healthy bone formation, and support tissue health.
Principal researcher Dr. Tom Gilhooly stated that in light of the
extraordinary result of this preliminary study an expanded, peer-reviewed
study is merited.P. O. Box 11686 Lexington, KY 40577 Phone: (888) 521-8867
Website: www.baxyl.com Key Component of
Baxyl Believed to be the First Orally Administered Hyaluronan Supplement to
Protect Cartilage and Bone Researchers from Kentucky, MO, and Ontario,
Canada believe MHB3 hyaluronan— the key component of the joint supplement
Baxyl®—may have profound results in protecting healthy cartilage and bone,
and supporting overall joint health.
MHB3 is a patent-pending, modified hyaluronan biopolymer molecularly
engineered using a proprietary process that assures consistency in
molecular profile, molecular weight and polydispersity. The fully hydrated
MHB3 is believed to be a primary reason for Baxyl’s efficacy.
It is a tall challenge to prove that any oral supplement is bioavailable,
let alone has beneficial effect.
Yet, that was the challenge taken up by researchers at the University of
Western Ontario, thought leaders on cartilage and osteoarthritis research.
In a preclinical investigation, Dr. Ian Welch and his fellow researchers
confirmed MHB3’s support of healthy cartilage in a model of osteoarthritis.
Welch concluded, “The effect of Baxyl’s proprietary MHB3 formulation in
supporting healthy articular cartilage was dramatic.” I spend most of my
professional time helping people deal with joint pain and inflammation by
prescribing drugs, injecting joints and, in the worst cases, replacing
joints entirely. Therefore, the idea of systemically supporting cartilage
with Baxyl had tremendous appeal to my patients and me.
One quarter of the American adult population report chronic joint symptoms
(CJS). Over 50 percent of those reporting CJS have symptoms with multiple
joints. Among those reporting CJS, the joints most effected where the knee
(58 percent), the shoulder (30 percent), the fingers/thumb (27 percent),
the hip (24 percent) and the ankle (22 percent).
For the clinical trial CJS was defined as joint pain, aching and stiffness
during the past 30 days with symptoms onset for over three months.
Treatment of CJS is usually limited to short-term symptom control with
palliative over-the-counter and prescription drugs.
Hyaluronan, found throughout the body’s tissues and fluids, has multiple
complementary mechanisms of action.
Hyaluronan directly affects the composition of synovial fluid and provides
the backbone for cartilage matrix. Apart from its structural role,
hyaluronan influences cell proliferation, differentiation and migration,
angiogenesis, as well as inflammation and immune cell function.
The evaluation of 50 adult subjects (avg. 59 years) with CJS was conducted
to identify the effects of daily oral supplementation with MHB3. Subjects
selfadministered .5-1 tsp. Of the viscous syrup twice daily for 30
consecutive days. Participants completed direct feedback surveys daily
helping facilitate compliance. Subjects identified the affected joints,
their pain levels and daily activity levels.
Forty-two subjects (84 percent) reported good to excellent results in
relief of pain and stiffness. To be included in the “good to excellent”
group the subject had to report a noticeable improvement in joint symptoms
with continued relief once the effect was noticed. Four subjects (eight
percent) noticed only minimal benefit during the trial but within four to
five days of trial termination reported an increase in pain and stiffness,
concluding that improvements were gradual and unremarkable during the
trial. This group is not included with the positive results reported above.
Four subjects (eight percent) reported no benefits during the trial.
Time to improvement ranged from five to 30 days with an average of 21 days.
There were no reports of side effects or drug interactions, and no one
discontinued the trial. Several subjects voluntarily reduced their
non-steroidal anti-inflammatory drug (NSAID) use based on improvements
during the trial.
It was concluded that the daily supplementation of Baxyl with MHB3
hyaluronan relieves joint pain and inflammation contributing to an improved
range of motion and an increase in daily activity among the majority of
subjects with CJS.
Additionally, it was found that the use of Baxyl is safe, as there were no
side effects, drug interactions or contra-indications reported.
To learn more about these studies, visit:
References Welch, I, Hill, T. “Effects of a Modified Hyaluronan Biopolymer
(MHB3) on Cartilage Loss in a Monoarthritis Model 2008.”
Welch, I, Hill, T. “Evaluation of a Modified Hyaluronan Biopolymer (MHB3)
on Cartilage Loss and Osteophyte Formation in a Knee Instability Model
Bucci, L, Turpin, A. “Will the Real Hyaluronan Please Stand Up?” J Appl
Nutri, Vol 54;1,2004.
Suggested Use: 1 tsp orally twice daily for first 7 days followed by 1/2 tsp twice daily for maintenance.
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None of the above statements have been evaluated by the FDA. These
products are not intended to diagnose, treat, cure or prevent any
disease. As always, consult your physician before taking any and
all supplements. LifeSource Vitamins. Individual results may vary.
All the information contained throughout this website is based upon the
opinion of the founder of LifeSource Vitamins Bruce Brightman, and the
entire team at LifeSource Vitamins whose relentless research and
studies have been ongoing on since 1992. Other articles and information
are based on the opinions of the authors, who retains the copyright as
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care into your own hands is always best, especially in partnership with
your health care professional. If you are pregnant, nursing, taking
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