Common uses for supplemental Acetyl-L Carnitine:
Studies demonstrate that ALC treatment is efficacious in alleviating
symptoms, particularly pain, and improving nerve fiber regeneration and
vibration perception in patients with established diabetic neuropathy*
Involved in the metabolism of food into energy.*
Mild mental impairment in the elderly showed a significant improvement
of several performances during and after Acetyl-l-carnitine treatment.*
Reports indicate that Acetyl-l-carnitine may be effective in the
treatment of dementia.*
Treated Down syndrome patients showed statistically significant
improvements in visual memory and attention both in absolute terms and
in comparison with the other groups.*
To significantly reduce the severity of depression symptoms in the
To significantly improve items measuring the quality of life. Overall
Improve both spatial and temporal memory, and reduce the amount of
oxidative damage to RNA in the brain's hippocampus, an area important
in memory. Acetyl-l-carnitine is widely used as an energy supplement.*
Increase sperm mobility in men, and improves overall virility in men.*
has been shown to improve the condition of essential mitochondria in
animals. These are the vital source of energy production in the body.*
- Shown to support healthy cognition, memory, and emotional well-being. This
amino acid is the acetylated form of l-carnitine, providing an important
energy supporting metabolite. Acetyl-l-carnitine is supportive for the
cardiovascular system, as well as healthy brain cognition.*
Acetyl-L Carnitine is the acetylated form of l-carnitine, and the two
compounds share similar energy and metabolism-promoting properties. Found
naturally in the body, acetyl l-carnitine supports the availability of
acetyl-CoA, an important energy-generating metabolite. In addition, it
supports healthy mitochondrial function and cell membrane stability.*
What is it?
Acetyl-L Carnitine is the acetylated form of l-carnitine. The two compounds
share similar energy and metabolism-promoting properties. Found naturally
in the body, acetyl L-carnitine supports the availability of acetyl-CoA, an
important energy-generating metabolite. In addition, it supports proper
mitochondrial function and cell membrane stability. The acetyl group from
acetyl-l-carnitine is also responsible for the production of acetylcholine,
an important neurotransmitter for optimal mental functioning.*
Uses For Acetyl-L Carnitine*
Support For Cognitive Function, Memory, And Emotional Well-Being: The
efficacy of long-term acetyl L-carnitine supplementation was determined in
a double-blind, placebo-controlled, randomized trial involving 130 elderly
individuals for a one-year period. In this trial, acetyl-l-carnitine
demonstrated the ability to slow negative cognitive changes, and supported
memory and attention. In another randomized double-blind study, three-month
acetyl-l-carnitine supplementation provided statistically significant
support for mental function, including memory and attention, compared to
placebo. A multicenter trial of 481 volunteers showed significant memory,
behavioral and emotional support with acetyl L-carnitine supplementation.
In an evaluation of 28 elderly individuals using acetyl l-carnitine or
placebo, the supplemented group experienced enhanced emotional well-being.*
Acetyl L-Carnitine has been shown to help with brain function, cognitive
function, and healthy aging, as well as overall nervous system health.
Creates optimally healthy energy levels, helps muscles use fat as an energy
source, and also stimulates the mind and body while promoting a healthy
What are the Scientific Evidence and Facts for Acetyl L-Carnitine
L-Carnitine - ALCAR Angina*
Carnitine might be a good addition to standard therapy for angina. In one
controlled study, 200 individuals with angina (the exercise-induced
variety) took either 2 g daily of L-Carnitine or were left untreated. All
the study participants continued to take their usual medication for angina.
Those taking Carnitine showed improvement in several measures of heart
function, including a significantly greater ability to exercise without
chest pain.70 They were also able to reduce the dosage of some of their
heart medications (under medical supervision) as their symptoms decreased.
Another trial that did use a double-blind, placebo-controlled design tested
L-Carnitine in 52 individuals with angina and found evidence of benefit. In
addition, several small studies (some of them double-blind) tested
Propionyl-L-Carnitine for the treatment of angina, and also found evidence
ALCAR and Hardening of The Arteries*
People with advanced hardening of the arteries, or atherosclerosis, often
have difficulty walking due to lack of blood flow to the legs. Pain may
develop after walking less than half a block. Although Carnitine does not
increase blood flow, it appears to improve the muscle's ability to function
under difficult circumstances.
A 12-month double-blind placebo-controlled trial of 485 patients with
intermittent claudication evaluated the potential benefits of
Propionyl-L-Carnitine. Participants with the relatively severe disease
showed a 44% improvement in walking distance as compared to placebo.
However, no improvement was seen in those with mild disease. Another
double-blind study followed 245 people and also found benefit.
Similar results have been seen in most but not all other studies of
L-Carnitine or Propionyl-L-Carnitine. Propionyl-L-Carnitine may be more
effective for intermittent claudication than plain Carnitine.
L-Carnitine - ALCAR Congestive Heart Failure*
Several small studies have found that Carnitine, often in the form of
propionyl-L-carnitine, can improve symptoms of congestive heart failure. In
one trial, benefits were maintained for 60 days after treatment with
Carnitine was stopped.
ALCAR After a Heart Attack*
Carnitine may help reduce the death rate after a heart attack. In a
12-month placebo-controlled study, 160 individuals who had experienced a
heart attack received 4 g of L-Carnitine daily or placebo, in addition to
other conventional medication. The mortality rate in the treated group was
significantly lower than in the placebo group, 1.2% versus 12.5%,
respectively. There were also improvements in heart rate, blood pressure,
angina (chest pain), and blood lipids. A larger double-blind study of 472
people found that Carnitine may improve the chances of survival if given
within 24 hours after a heart attack. Note: Carnitine is used along with
conventional treatment, not as a substitute for it.
Chronic Obstructive Pulmonary Disease (COPD)*
Evidence from three double-blind placebo-controlled studies enrolling a
total of 49 individuals suggests that L-Carnitine can improve exercise
tolerance in COPD, presumably by improving muscular efficiency in the lungs
and other muscles.
L-Carnitine - ALCAR and Mild Depression*
A double-blind study of 60 seniors with mild depression found that
treatment with 3 g of Carnitine daily over a 2-month period significantly
improved symptoms as compared to placebo. Positive results were seen in
another study as well.
L-Carnitine - ALCAR and Hyperthyroidism*
Enlargement of the thyroid (goiter) can be due to many causes, including
cancer and iodine deficiency. In some cases, thyroid enlargement occurs
without any known cause, so-called benign goiter.
Treatment of benign goiter generally consists of taking thyroid hormone
pills. This causes the thyroid gland to become less active, and the goiter
shrinks. However, there may be undesirable effects as well. Symptoms of
hyperthyroidism (too much thyroid hormone) can develop, including heart
palpitations, nervousness, weight loss, and bone breakdown.
A double-blind, placebo-controlled trial found evidence that the use of
L-Carnitine could alleviate many of these symptoms. This 6-month study
evaluated the effects of L-Carnitine in 50 women who were taking thyroid
hormone for benign goiter. The results showed that a dose of 2 or 4 g of
Carnitine daily protected participants' bones and reduced other symptoms of
Carnitine is thought to affect the thyroid hormone by blocking its action in
cells. This suggests a potential concern: Carnitine might be harmful to
people who have low or borderline thyroid levels, to begin with. This
possibility has not been well explored as yet.
ALCAR and Peyronie's Disease*
Peyronie's disease is an inflammatory condition of the penis that develops
in stages. In the first stage, penile pain occurs with erection; next, the
penis becomes curved; finally, erectile dysfunction may occur. Many
medications have been tried for Peyronie's disease, with some success. One
such drug is tamoxifen (better known as a treatment to prevent breast
cancer recurrence.) A 3 month, double-blind study compared the
effectiveness of Acetyl-L-Carnitine (1 gram twice daily) against tamoxifen;
the study enrolled 15 men in the first stage of Peyronie's disease and 33
men in the second stage. The result indicated that Acetyl-L-Carnitine
reduced penile curvature while tamoxifen did not; the supplement also
reduced pain and slowed disease progression to a greater extent than the
drug. Furthermore, while the drug caused various side effects, the
supplement caused none.
ALCAR and Athletic Performance Enhancement*
A 1996 review of clinical studies concluded that no scientific basis exists
for the belief that Carnitine supplements enhance athletic performance. A
few studies have found some benefit, but most have not.
ALCAR Safety Issues
L-Carnitine in its three forms appears to be quite safe. However,
individuals with low or borderline-low thyroid levels should avoid
Carnitine because it might impair the action of thyroid hormone.
Individuals on dialysis should not receive this (or any other supplement)
without a physician's supervision. The maximum safe dosages for young
children, pregnant or nursing women, or those with severe liver or kidney
disease have not been established.
L-Carnitine - Interaction Drug Side Effects You Should Know About
If you are taking;
Anti-seizure medications, particularly valproic acid (Depakote,
Depakene) but also phenytoin (Dilantin): You may need extra Carnitine.
• Thyroid medication: Do not take Carnitine except under a physician's
See All LifeSource Vitamins Acetyl-L Carnitine Products, Articles
Acetyl L-Carnitine can help support healthy cognition, memory, emotional
well-being, as well as helping muscles use fat as an energy source. Acetyl
L-Carnitine also promotes a healthy cardiovascular system.
Check with your doctor first if you're taking:
Carnitine may interact with drugs or supplements that lower blood sugar. It
may affect how your body breaks down certain drugs and supplements.
Carnitine may increase the effects of or have other interactions with many
drugs. It may also interact with a number of herbs and supplements. Avoid
using this supplement with D- or DL-carnitine.
Tell your doctor about any supplements you're taking, even if they're
natural. That way, your doctor can check on any potential side effects or
interactions with any medications.
Shown to support healthy cognition, memory, and emotional well-being. This
amino acid is the acetylated form of l-carnitine, providing an important
energy supporting metabolite. Acetyl-l-carnitine is supportive of the
cardiovascular system, as well as healthy brain cognition.
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