CoQ10 - Decreased CoQ10 levels in coronary care unit patients
associated with inflammation and in-hospital mortality.
On December 9, 2016 in the journal Heart and Vessels, researchers from
Japan's Juntendo University School of Medicine reported the finding of a
greater risk of inflammation, malnutrition and dying while hospitalized
among coronary care unit patients with lower coenzyme Q10 (CoQ10) levels.
The study included 257 men and women with cardiovascular disease admitted
to Juntendo University Hospital's coronary care unit (CCU) from April 2012
to January 2013. Diagnoses included ischemic cardiomyopathy, nonischemic
cardiomyopathy, acute coronary syndrome, arrhythmia, venous
thromboembolism, aortic disease and others. Fasting blood samples collected
within 24 hours of admission were analyzed for serum CoQ10, plasma lipids,
glucose, C-reactive protein (CRP, a marker of inflammation) and additional
Coenzyme Q10 levels averaged 0.54 milligrams per liter (mg/L) among CCU
patients in the current study. (In comparison, a study that measured CoQ10
levels among 146 healthy older individuals in the U.S. found average levels
of 0.71 mg/L.) Patients who were treated with statins had CoQ10 levels that
averaged 0.46 mg/L, in comparison with an average of 0.58 mg/L among those
who were not being treated with the drugs. Lower CoQ10 levels were
associated with higher CRP levels, indicating an inflammatory state.
Decreased CoQ10 levels were also associated with having a lower body mass
index (BMI) which suggested malnutrition.
Within an average of 38 days from the time of admission, 14 deaths occurred
among the study's subjects. Serum CoQ10 levels were significantly lower, at
an average of 0.43 mg/L, among those who died compared to levels that
averaged 0.55 mg/L among survivors.
The authors note that CoQ10's ability to improve cellular bioenergetics
contributes to its potential role in heart failure prevention and therapy.
It also has antioxidant and vasodilatory effects that can benefit the
"To our knowledge, this is the first study to measure CoQ10 levels in
patients with varied acute cardiovascular diseases," authors Megumi Shimizu
and colleagues announce.
"Numerous studies have demonstrated various beneficial effects of CoQ10
supplementation on cardiovascular disease," they write. "Indeed, CoQ10
supplementation increases cardiac mitochondrial CoQ10 levels to improve
cardiac function, and improves endothelial function, which is a critical
risk factor for atherosclerotic diseases. Therefore, further prospective
studies are warranted to elucidate the effects of CoQ10 supplementation on
the prognosis of critical cardiovascular disease in patients admitted to
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