Iron Supplements May Help Fatigued Women
Women who experience unexplained fatigue, but who are not anaemic may benefit from iron supplementation.
However, the effect of any iron supplementation may be restricted to women with low or borderline serum ferritin concentrations, reports Dr Bernard Favrat and colleagues at the University of Lausanne, Switzerland. They think their study is the first randomised clinical trial in women of childbearing age to show that iron supplementation could have an effect on fatigue in the absence of anaemia.
The clinicians point out that while the symptoms of fatigue are related to iron deficiency anaemia, there is a lack of evidence for any association between deficiency and tiredness in the absence of anaemia. Their double-blind randomised placebo controlled trial was among 144 women aged 18 to 55, referred from 8 family practices. Seventy- five women were assigned for 4 weeks to oral ferrous sulphate (80 mg/day of elemental iron daily), and 69 women to placebo.
Among the 136 women who completed the trial, most had a low serum ferritin concentration, and it was less than 20 g/L in 69 (51%) of them. Mean age, haemoglobin concentration, serum ferritin concentration, level of fatigue, depression, and anxiety were similar in both groups at baseline, as well as compliance in the trial.
The level of fatigue after one month decreased by - 1.82/6.37 points (29%) in the iron group, compared with - 0.85/6.46 points (13%) in the placebo group (difference 0.95 points).
Subgroups analysis showed that only women with ferritin concentrations of less than 50 g/l improved with oral supplementation. 'This suggests that iron deficiency could be present even with a 'normal' concentration of serum ferritin, Dr Favrat and colleagues said.
"Indeed, the lower limit for serum ferritin concentration is controversial: iron stores in the bone marrow may serve as a better indicator of iron deficiency, they add. The lower reference limits for serum ferritin and haemoglobin concentrations have been considered too low for women and it has been suggested should be the same as for men."
BMJ 2003;326: 1124-1126.
British Medical Journal (BMJ)
By Harvey McConnell
E-mail Us: info@LifesourceVitamins.com
Call Us: 800.567.8122
We Are Built on Compassion - Driven by Faith & Powered by
Questions? It can be overwhelming we know. Call us, we will walk you through what
supplements will help you and which ones you really don’t need. It’s
what we do!
*Disclaimer: None of the above statements
have been evaluated by the FDA. These products are not intended to diagnose,
treat, cure or prevent any disease. As always, consult your physician before
taking any and all supplements. LifeSource Vitamins. Individual results may
Disclaimer: All the
information contained throughout this website is based upon the opinion of the
founder of LifeSource Vitamins, Bruce Brightman, and the entire team at
LifeSource Vitamins whose relentless research and studies have been ongoing on
since 1992. Other articles and
information are based on the opinions of the authors, who retains the copyright
as marked on the article. The
information on this site is not intended to replace your health care
professional, but to enhance your relationship with them. Doing your own studying and research and
taking your health care into your own hands is always best, especially in
partnership with your health care professional.
If you are pregnant, nursing, taking medications, or have any medical
conditions, always consult your health care professional before taking
supplements based on the information on this site.