When it comes to naturally boosting the immune system by
optimizing its response to diseases and infections, beta-glucans are
crucial weapons in the fight to stay healthy. But because the body doesn't
produce beta glucans naturally, the only way to get the compound is through
outside sources, this is why we at LifeSource Vitamins have added this to
our line of supplements.
Beta Glucan is a powerful immune stimulator, activating the macrophages in
the immune system. Studies have found that this product not only has a
positive effect on the macrophages, but also on B lymphocytes, natural
killer cells, and suppressor T cells. In addition to these important
functions, Beta Glucan is an effective antioxidant and free radical
Macrophage cells play an essential role in the maintenance of the immune
Macrophages are the cells that recognize, engulf and destroy any cells
organisms, and substances that are not natural or required by the body
(bacteria, viruses, fungi, dead or mutated cells, etc.)
· A release of important cytokines, such as IL-1, IL-2 among others,
initiating immune cascade and triggering other cell lines, such as T-cells.
A release of colony-stimulating factors, boosting bone marrow production. *
It also can produce a number of essential cytokines that are able to
stimulate the immune system in general and boost bone marrow production. In
addition to having a huge appetite for toxins, macrophages play a pivotal
role in the initiation of immune responses. Once a foreign body attacks the
body, the macrophages become activated, and a chain reaction occurs that
mobilizes the entire immune system.*
There have been over 1,000 research papers on Beta 1,3-D Glucan since the
1960s. Research-backed by prestigious institutions such as the U.S. Food
and Drug Administration, Harvard, Tulane, Baylor, McGill, University of
California, Duke, Washington, Armed Forces Radiology Research Institute,
and other institutions all demonstrate the high immune-activating
properties of Beta Glucan. Beta Glucan has been found to stimulate or
modulate macrophage cells (leukocytes, or white blood cells).*
Why add Maitake Mushrooms? It really is a natural addition. The Maitake
mushroom has an active ingredient called beta-glucan. These mushrooms have
been used in Japan for centuries, and they are believed to promote
longevity and overall well-being. It’s a polysaccharide found in other
medicinal mushrooms. The Maitake Mushroom, however, contains one called
D-fraction. Researchers believe that it is this beta-glucan that gives the
mushroom its healing powers. Unlike common mushrooms, Maitake’s are packed
with unbelievably healthy nutrients such as powerful antioxidants, Vitamins
B, C and also Niacin. They are also packed with minerals like iron, zinc,
potassium, selenium, protein, amino acids and fiber.
Shown to Support immune health; researched for over 2 decades:
- Activation of macrophages, expressing increased nonspecific phagocytic
ability allowing macrophages to destroy pathogens more efficiently,
frequently preventing disease.*
- Ideal for people who exercise more than the average*
- Serious Athletes, Professional Athletes in any sport, Body Builders,
Runners, anyone who overexerts continually.*
- The release of important cytokines, such as IL-1, IL-2 among others,
initiating immune cascade and triggeringother cell lines, such as T-cells.
The release of colony-stimulating factors, boosting bone marrow production.*
- Cholesterol-reduction through cell activation and anti-oxidant activity*
- Diabetes Support*
Blood Sugar Support*
- Helps with Radiation Support*
- A bio-active Carbohydrate*
- Nourishes and stimulates the immune system*
Keeping Your Immune System Strong
Our immune system protects our bodies against viruses, bacteria, fungi,
parasites, and much more. It is a miraculous complex network of organs that
contain cells that recognize and destroy foreign invaders. Some
individuals, because of age, poor nutrition, stress, unhealthy lifestyle,
or environmental toxins have a compromised immune system.* Specialized
white blood cells called macrophages, and they are the first line of
defense of your immune system. Macrophages are essentially the "guard dogs"
of your immune system, and constantly on alert.
What do these Beta Glucans do?
BOOSTS THE IMMUNE SYSTEM
One of the health benefits is boosting the immune system. It actually works
by activating the white blood cells, specifically neutrophils, and
macrophages. These white blood cells are the immune system's line of
defense against pathogens and foreign invaders in the body. Neutrophils and
macrophages activated by beta-glucan aid in recognizing and destroying
tumor cells, accelerate repair of damaged tissue, help remove cellular
waste caused by oxidative damage, and help activate the immune system's
other components. *
BLOOD SUGAR CONTROL
It is a soluble fiber that helps decrease the absorption of sugar that
comes from the diet. Several studies have suggested the value of
beta-glucan in keeping blood sugar levels under control but more studies
are needed in order to verify this data. Strong evidence shows that people
who incorporated more foods that produce a low glycemic response in their
diets had a significant improvement in diabetes control. *
See All LifeSource Vitamins Blood Sugar Products, Articles, and
Article: Blood Sugar, Also Shown Improvement with Psyllium:
LOWER CHOLESTEROL LEVELS
Due to the gel-like substance that is produced from beta-glucan when it is
dissolved in the digestive tract, it is quite effective in reducing bad
cholesterol or LDL and the overall cholesterol level in the body. Lower
cholesterol levels mean a decreased chance of developing heart diseases
like coronary heart disease. *
See All LifeSource Vitamins Cholesterol Fighting Products, Articles
Heart disease study:
A randomized controlled crossover study of the effect of highly
beta-glucan-enriched barley on cardiovascular disease risk factors in
mildly hypercholesterolemic men.
Department of Medicine, the Human Nutrition & Metabolic Unit,
University of Auckland, New Zealand.
Soluble-fiber beta-glucan derived from oats can reduce cardiovascular
disease (CVD) risk through reductions in total and LDL cholesterol.
Barley-derived beta-glucan may also improve serum cholesterol, but large
quantities are required for clinical significance. This trial investigated
whether a beta-glucan-enriched form of barley can favorably modify
cholesterol and other markers of CVD and diabetes risk. Eighteen mildly
hyperlipidemic men were randomly assigned in this single-blind, 2 x 4-wk
trial to either the treatment arm or the control arm. After a washout
period of 4 weeks, dietary regimens were crossed over. There was no
significant change in total, LDL, or HDL cholesterol or in triacylglycerol,
fasting glucose, or postprandial glucose when analyzed between treatments.
The effect of beta-glucan-enriched barley on lipid profile was highly
variable between subjects, and there was no evidence of a clinically
significant improvement in CVD risk across this group of mildly
Effects of oat beta-glucan on innate immunity and infection after exercise
Med Sci Sports Exercise. 2004.
To test the effects of oat beta-glucan on respiratory infection, macrophage
antiviral resistance, and NK cytotoxicity it was fed to mice in the
drinking water for 10 days before intranasal inoculation of HSV-1 or
sacrifice. Our data suggest that daily ingestion of beta-glucan may offset
the increased risk of upper respiratory infection associated with exercise
stress, which may be mediated, at least in part, by an increase in
macrophage antiviral resistance.
One of the most remarkable oral studies with beta-1,3-glucan was done at
the US Armed Forces Radiobiology Institute.
In a well-controlled study, 70% of rats given a lethal dose of
radiation were completely protected from radiation effects when given a
dose of yeast beta glucan by mouth AFTER the radiation16.
Dr. Myra Patchen discovered that beta-glucan is also a free radical
scavenger. It is able to protect blood macrophages from free radical attack
during and after the radiation allowing these cells to continue to carry
their important functions in the irradiated body and release factors
important to the restoration of normal bone marrow production. Patchen ML,
D'Alesandro MM, Brook I, Blakely WF, McVittie TJ: Glucan: mechanisms
involved in its "radioprotective" effect.. J Leuc Biol 1987; 42: 95-105.
6 Health Benefits of Maitake Mushrooms
The Maitake mushroom has been prized in Asia for thousands of years for its
health benefits. The Japanese word "Maitake" means "dancing mushroom," a
name derived from the reaction of people having found these mushrooms,
which were actually worth their weight in silver. Modern research on the
Maitake mushroom only began in Japan in the 1980s and has just recently
begun to be conducted to the United States. Most research has been done on
the extract rather than the fresh mushroom and tests on humans are limited.
Maitake mushrooms are highly sought after for their anti-cancer properties.
They are abundant in polysaccharides and polysaccharide-protein complexes
that the body uses to fortify the immune system. The mushroom’s beta-glucan
content works to promote important immune system functions, effectively
activating white blood cells that fight off microorganisms that cause
disease, including cancer. Maitake mushrooms enhance the activity of cells,
inducing the production of interleukins and other lymphokines that have
chemoprotective effects, slow tumor growth, and help to inhibit the spread
Immune System Support
Maitake mushrooms grow primarily in northeastern Japan and the United
States and are esteemed by traditional Chinese medicine for fighting
disease and improving immunity. Regular consumption of Maitake enhances the
immune system as well as lowers blood pressure. The most effective
ingredient in the mushroom is its beta-glucan, a polysaccharide compound
that boosts the immune system through the activation of macrophage cells,
natural killer cells, and T-cells. These cells play an important role in
building general immunity and preventing free radicals from harming the
Blood Sugar Control
The consumption of Maitake mushrooms may regulate blood sugar levels and
blood lipid levels. The polysaccharide compounds that promote the strength
of the immune system are also effective in helping to regulate blood
pressure, glucose, insulin, and lipids. This effect is especially
beneficial for people with diabetes or hypoglycemia. People with Type 2
Diabetes may also benefit from Maitake mushrooms. Scientists have studied a
specific, high-molecular polysaccharide in Maitake called the X-fraction.
Research results suggest that Maitake mushrooms can reduce insulin
resistance and increase insulin sensitivity.
Lower Blood Pressure
Research on animals suggests that Maitake may help lower blood pressure in
people. One study gave hypertensive rats a 5% Maitake mushroom powder and
observed a reduction in blood pressure. Similar results were seen from
another study on rats, in which Maitake lowered blood pressure from 200 to
115 mm Hg in just 4 hours. In an unpublished trial on humans, eleven
patients with hypertension took 500 mg of Maitake mushroom pills twice a
day. A mean decrease in diastolic blood pressure of approximately 8 mm Hg
and a mean decrease in systolic blood pressure of about 14 mm Hg were
In one study on hyperlipidemic rats, Maitake changed lipid metabolism
through inhibiting the aggregation of liver lipids and the raising of serum
lipids. Similar results were seen in rats fed a high-cholesterol diet. In
another study, rats given powdered mushroom preparations saw a drop in both
total cholesterols and very low-density lipoprotein-cholesterol.
Maitake mushrooms can promote weight loss and decrease obesity when
combined with light exercise. Studies on overweight rats fed Maitake powder
found that after 18 weeks, they had lost weight compared with controls.
They contain no cholesterol, no fats and are very low carbohydrates.
Additionally, the high lean protein content of mushrooms helps burn
cholesterol during digestion.
Cholesterol management & Beta Glucan
The effects of concentrated barley beta-glucan on blood lipids in a
population of hypercholesterolemic men and women.
Br J Nutr. 2007. University of Minnesota, Medical School, Department of
Family Medicine and Community Health, Minneapolis, MN, USA.
We evaluated the cholesterol-lowering effect of a concentrated barley
beta-glucan extract as a vehicle to deliver this potential health benefit
of barley. In a 10-week blinded controlled study, subjects were randomized
to one of four treatment groups or control. Treatment groups included
either high molecular weight or low molecular weight barley beta-glucan
extract at both 3 and 5 g doses. Treatment was delivered twice per day with
meals in the form of two functional food products: a ready-to-eat cereal
and a reduced-calorie fruit juice beverage. After 6 weeks of treatment the
mean LDL- Cholesterol levels fell by 15 % in the 5 g HMW group, 13 % in the
5 g LMW group and 9 % in both the 3 g/d groups, versus baseline. Similar
results were observed for total cholesterol. HDL-C levels were unchanged by
Oat-derived beta-glucan significantly improves HDL Cholesterol and
diminishes LDL Cholesterol and non-HDL cholesterol in overweight
individuals with mild hypercholesterolemia.
Am J Ther. 2007. Center for Metabolic and Endocrine Research, The
University of Zulia, Maracaibo, Venezuela.
To investigate the effect of bread formulated with 6 g of beta-glucan (oat
soluble fiber) on serum lipids in overweight subjects with high cholesterol
levels. Thirty-eight male subjects who were eligible for the study ate an
isocaloric diet for a 1-week period. They were then divided into 2 groups:
group A, who were maintained on American Heart Association (AHA) Step II
diet, including whole wheat bread, and group B, who were maintained on AHA
Step II diet containing high levels of monounsaturated fatty acids plus
bread containing 6 grams of beta-glucan (Nutrim-OB) for 8 weeks. There was
a significant increase in plasma high-density lipoprotein cholesterol in
the beta-glucan group, but there was no change in group B. There was a
significant reduction in total cholesterol in the 2 groups to approximately
the same extent. Plasma low-density lipoprotein (LDL) cholesterol also
decreased significantly in the two groups; however, the beta-glucan
fortified diet was significantly more effective. The beta-glucan diet also
decreased fasting plasma glucose, whereas the other diet had no effect. Six
grams of beta-glucan from oats added to the AHA Step II diet and moderate
physical activity improved lipid profile and caused a decrease in weight
and, thus, reduced the risk of cardiovascular events in overweight male
individuals with mild to moderate hypercholesterolemia.
Dr. Ronald Mensink, of Maastricht University, tested 25 healthy subjects
who drank a fruit drink containing beta-glucan from oats and 22 healthy
subjects who drank a fruit drink containing 5 grams of rice starch, which
served as a placebo. All of the subjects drank the juice every day for five
weeks. Compared with the placebo group, total cholesterol was reduced by 5
percent and LDL cholesterol by 7.7 percent in the beta-glucan group. The
investigators also found that the beta-glucan drink decreased cholesterol
absorption and increased synthesis, without affecting levels of fat-soluble
antioxidants. American Journal of Clinical Nutrition, March 2006.
Beta Glucan incorporated into a fruit drink effectively lowers serum
LDL- cholesterol concentrations. American Journal of Clinical
We examined the effects of a beta-glucan-enriched fruit juice on serum
lipids and lipoproteins and on markers of cholesterol absorption (serum
concentrations of plant sterols) and synthesis (serum concentrations of
lathosterol). Beta Glucan lowers serum concentrations of total and LDL
cholesterol when incorporated into a fruit drink without affecting plasma
concentrations of lipid-soluble antioxidants.
Sweeteners and beta-glucans improve metabolic and anthropometric
variables in well-controlled type 2 diabetic patients. Am J Ther. 2003.
A total of 16 male, well-controlled type 2 diabetes patients were divided
into two groups of eight; one group received the diet based on the American
Diabetic Association's nutrition recommendations, and the other was fed a
modified, low-calorie diet containing a fat replacer (beta-glucans derived
from oats) and the sweeteners, sucralose and fructose. Both diets produced
significant improvements in weight, body mass index, lipid profile, basal
glucose, and HbA1C. However, the beta-glucan diet was superior to the
American Diabetic Association's diet in improving metabolic and
anthropometric profile: greater increase in HDL cholesterol and larger
decreases in HbA1C, weight, and body mass index.
Dietary supplementation with beta-glucan-enriched oat bran increases the
fecal concentration of carboxylic acids in healthy subjects. European
Journal of Clinical Nutrition 2007; Applied Nutrition and Food Chemistry,
Department of Food Technology, Center for Chemistry and Chemical
Engineering, Lund University, Lund, Sweden.
Carboxylic acids, especially butyric acid, have been suggested to
counteract colonic diseases, such as ulcerative colitis and colon cancer.
To elucidate how the colonic concentration of carboxylic acids in healthy
subjects is influenced by dietary supplementation with oat bran, and
whether the concentration varies over time and during consecutive days.
Twenty-five healthy subjects were given 40 g beta-glucan-enriched oat bran
per day, corresponding to 20 g dietary fiber, in 4 slices of bread. After
12 weeks, the concentrations of acetic, propionic and isobutyric acid were
higher and that of lactic acid lower. The variation between individuals was
considerable, whereas in the same individuals there was little variation.
Oat bran increased the fecal concentration of carboxylic acids after 8
weeks, indicating an increased concentration also in the distal colon. The
concentration of all main acids increased, except for lactic acid, which
decreased. Oat bran may, therefore, have a preventive potential adjunct to
Diabetes and blood sugar control
Beta-glucan may be helpful in blood sugar control. The addition predictably
reduces the glycemic index. In a 50 g carbohydrate portion, each gram of
beta-glucan reduces the glycemic index by 4 units, making it a useful
functional food component for reducing postprandial glycemia. It has also
been tested for cholesterol level support.
Studies have found that Beta Glucan not only has a positive effect on the
macrophages, but also on B lymphocytes, natural killer cells, suppressor T
cells, and free radical scavengers.
LifeSource Vitamins Ultra Beta Glucan with Maitake Mushrooms, Beta -
1,3/1,6 -D- Glucan, When it comes to naturally boosting the immune systems
by optimizing its response to diseases, beta glucans are crucial weapons in
the fight to stay healthy.
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requirements set forth in the FDA’s
Code of Federal Regulation
as well as all Good Manufacturing Practices enforced by the FDA called
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control of manufacturing processes and facilities.
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