Pressure Support - 90 Vcaps
indicates that the role of Grape Seed Extract (GSE) in support of
cardiovascular health may extend beyond its important antioxidant functions.
Scientific studies have shown that the proprietary GSE found in LifeSource
Vitamins Blood Pressure Support, MegaNatural®-BP™ contains flavonoids
that can support healthy arterial function already within the healthy range
through a number of mechanisms. In fact, these studies suggest that MegaNatural®-BP™
can help maintain blood pressure already within the healthy range. In addition,
we have included standardized Hawthorn Extract as a synergist. Hawthorn Extract
provides powerful antioxidant flavonoids, including standardized Vitexin that,
along with other components in Hawthorn, have also been found to support
healthy range blood flow and healthy range blood pressure.*
- Cardiovascular Support*
- Helps maintain blood pressure already within the
- May help people with pre-hypertension manage their condition*
- Can help suppress inflammation*
- Vegetarian Formula
- Grape Seed Extract - MegaNatural®-BP™ w/ Hawthorn Berry
Why Does LifeSource
Vitamins use MegaNatural®-BP™?
made in California from a special seed blend primarily from varietal white wine
grapes. The seeds are extracted with hot water, the extract is purified,
concentrated and spray dried, loading natural grape phenolics into the extract,
and that extract powder is used as an ingredient for dietary supplements,
functional foods, and healthy beverages.
a patented grape seed extract that has been evaluated in human clinical studies
at the UC Davis Department of Internal Medicine. Studies evaluated subjects
with blood pressure levels in the normal to pre-hypertensive ranges. One
clinical, involving patients with Metabolic Syndrome, showed incidental blood
pressure reductions, averaging 12 mmHg for systolic and 8 mmHg for diastolic
pressures. In another study, participants with pre-hypertension took 300 mg of MegaNatural®-BP™ once
a day for two months, and blood pressure monitoring averaged in systolic
readings 8 mmHg lower and diastolic pressure lower by 5 mmHg. These studies
indicate that MegaNatural®-BP™ may offer a significant benefit for people with
technically healthy blood pressure that typically ranges on the upper end of
normal, a condition known as “pre-hypertension.”
MegaNatural®-BP™ is a distinct form of grape seed
extract in that it is backed by human clinical research, which is rare in the
industry. It is also supported by a portfolio of intellectual property,
including a trademarked brand name and manufacturing and usage patents, further
differentiating it from other commodity grape seed extracts. The ingredient
fills a need for a natural, effective solution to common health concerns, such
as high blood pressure, and is attractive to those seeking a solution without
the side effects associated with pharmaceutical drugs. MegaNatural®-BP™ has
achieved FDA No-Objection GRAS status, making it safe.
MegaNatural®-BP™ is rich in
polyphenolic substances, which are known vasodilators. In a UC Davis human
clinical study, patients taking 300 mg of MegaNatural®-BP™
daily for 8 weeks showed an 8 mm drop in systolic pressure verses zero for
those in a placebo group. When taken twice daily, LifeSource Vitamins Blood
Pressure Support contains the recommended 300 mg of MegaNatural®-BP™.
It is estimated that 60
million Americans have high blood pressure, and uncontrolled high blood
pressure (hypertension) is the leading risk factor for both heart attack and
stroke. Women are even more vulnerable to high blood pressure than men. Despite
lifestyle modifications and drugs, only about two-thirds of those who know they
have high blood pressure have it under control (usually with drugs). These
statistics make high blood pressure the number one concern of cardiologists and
Blood pressure is the
result of a complex system that includes not only the heart and blood vessels,
but also hormones and protein messengers. As the heart pumps, it sends blood
through arteries. Healthy arteries expand under the pressure and contract when
the pressure wave passes. However, unhealthy or inelastic arteries cannot
expand, which causes higher pressure when the blood pumps.
Receptors in the kidneys
keep track of pressure and send hormone signals to the heart to speed up or
slow down as needed.
Why did LifeSource Vitamins add Hawthorn
Extract to our Blood Pressure Support?
Hawthorn is a common thorny shrub in
the rose family that grows up to 5 feet tall on hillsides and in sunny wooded
areas throughout the world. Its flowers bloom in May. They grow in small white,
red, or pink clusters. Small berries, called haws, sprout after the flowers.
They are usually red when ripe, but they may also be black. Hawthorn leaves are
shiny and grow in a variety of shapes and sizes.
It Made Of?
Hawthorn contains many substances
that may benefit the heart. These antioxidant flavonoids -- including OPCs --
may help dilate blood vessels, improve blood flow, and protect the blood
vessels from damage.
The berries, leaves, and flowers of
the hawthorn plant have been used for medicinal purposes. Most modern
preparations use the leaves and flowers, which are believed to contain more of
the flavonoids than the berries.
Uses and Indications
Hawthorn is used to help protect
against heart disease and help control high blood pressure and high
cholesterol. Both animal and human studies suggest hawthorn increases
coronary artery blood flow, improves circulation, and lowers blood pressure. It
has also been used on the skin to treat boils and skin sores.
Hawthorn has been studied in people
with heart failure (a condition in which the heart is unable to pump enough
blood to other organs in the body), but more studies are needed to understand
how effective it may be. A number of studies conclude that hawthorn
significantly improved heart function. Studies also suggest the herb can
enhance a person's ability to exercise following heart failure. Participants in
studies have reported that hawthorn significantly improved symptoms of the
disease (such as shortness of breath and fatigue). One study found that
hawthorn extract (900 mg/day) taken for 2 months was as effective as low doses
of captopril (a prescription heart medication) in improving symptoms of heart
A large study found that a
standardized hawthorn supplement was effective in 952 patients with heart
failure. The study compared conventional methods of treating heart failure
(with different medications) with hawthorn alone and in addition to the drugs.
After 2 years, the clinical symptoms of heart failure (palpitations, breathing
problems, and fatigue) decreased significantly in the patients taking the
hawthorn supplement. People taking hawthorn also took less medication for their
Heart failure is a serious
condition, and you should never try to self-treat with hawthorn. Ask your
doctor if hawthorn is right for you.
Chest pain (Angina)
Preliminary evidence suggests
hawthorn may help combat chest pain (angina), which is caused by low blood flow
to the heart. In one early study, 60 people with angina were given either 180
mg/day of hawthorn berry leaf flower extract or placebo for 3 weeks. Those who
received hawthorn experienced improved blood flow to the heart and were also
able to exercise for longer periods of time without suffering from chest pain.
However, more studies are needed to say for sure whether hawthorn is effective.
High blood pressure
Although hawthorn has not been
studied specifically in people with high blood pressure, some people think its
benefits in treating heart disease may carry over to treating high blood
pressure (hypertension). However, so far not enough research has been done to
say whether hawthorn is effective at lowering blood pressure -- and if so, by
In one study, hawthorn extract was
found to be effective for hypertension in people with type 2 diabetes who were
also taking prescribed medicines. Participants took 1,200 mg hawthorn extract
daily or placebo for 16 weeks. Those taking hawthorn had lower blood pressure
than those taking the placebo.
You should talk with your doctor
before taking hawthorn if you have high blood pressure.
of Maryland Medical Center
What is high blood
Blood pressure is a
measure of how hard the blood pushes against the walls of your arteries as it
moves through your body. It's normal for blood pressure to go up and down
throughout the day, but if it stays up, you have high blood pressure. Another
name for high blood pressure is hypertension.
When blood pressure is
high, it starts to damage the blood vessels, heart, and kidneys. This can lead
to heart attack, stroke, and other problems. High blood pressure is called a
"silent killer,'' because it doesn't usually cause symptoms while it is
causing this damage.
Your blood pressure consists of two numbers: systolic and diastolic. Someone
with a systolic pressure of 120 and a diastolic pressure of 80 has a blood
pressure of 120/80, or "120 over 80."
- The systolic number shows how hard the blood pushes
when the heart is pumping.
- The diastolic number shows how hard the blood pushes
between heartbeats, when the heart is relaxed and filling with blood.
Adults should have a blood pressure of less than 120/80. High blood pressure is
140/90 or higher. Many people fall into the category in between, called
prehypertension. People with pre-hypertension need to make lifestyle changes to
bring the blood pressure down and help prevent or delay high blood pressure.
What causes high blood pressure?
In most cases, doctors
can't point to the exact cause, but several things are known to raise blood
pressure; being very overweight, drinking too much alcohol, having a
family history of high blood pressure, eating too much salt, and getting older. Your blood pressure may
also rise if you are not very active, you don't eat enough potassium and
calcium, or you have a condition called insulin resistance.
What are the symptoms?
High blood pressure
does not usually cause symptoms. Most people don't know they have it until they
go to the doctor for some other reason
Without treatment, high
blood pressure can damage the heart, brain, kidneys, or eyes. This damage
causes problems like coronary artery disease, stroke, and kidney failure.
Very high blood pressure
can cause headaches, vision problems, nausea, and vomiting. Malignant high
blood pressure (hypertensive crisis), which is blood pressure that rises very
fast, can also cause these symptoms. Malignant high blood pressure is a medical
How is high blood pressure diagnosed?
Most people find out
they have high blood pressure during a routine doctor visit. For your doctor to
confirm that you have high blood pressure, your blood pressure must be at least
140/90 on three or more separate occasions. It is usually measured 1 to 2 weeks
You may have to check your blood pressure at home if there is reason to think
the readings in the doctor's office are not accurate. You may have what is
called white-coat hypertension, which is blood pressure that goes up just
because you're at the doctor's office. Even routine activities, such as
attending a meeting, can raise your blood pressure. So can commuting to work or
smoking a cigarette.
How is it treated?
Treatment depends on how
high your blood pressure is, whether you have other health problems such as
diabetes, and whether any organs have already been damaged. Your doctor will
also consider how likely you are to develop other diseases, especially heart
You can help lower your
blood pressure by making healthy changes in your lifestyle. If those lifestyle
changes don't work, you may also need to take pills. Either way, you will need
to control your high blood pressure throughout your life.
- If you have pre-hypertension, your doctor will likely
recommend lifestyle changes. This may include losing extra weight,
exercising, limiting alcohol, cutting back on salt, quitting smoking, and
eating a low-fat diet that includes more fruits, vegetables, whole grains,
and low-fat dairy foods.
- If you have high blood pressure without any organ
damage or other risk factors for heart disease, your doctor may recommend
that you take medicine in addition to making lifestyle changes.
- If you have high blood pressure and have some organ
damage or other risk factors for heart disease, you may need to try
various combinations of medicines in addition to making big lifestyle
Most people take more
than one pill for high blood pressure. Work with your doctor to find the right
pill or combination of pills that will cause the fewest side effects.
It can be hard to remember to take pills when you have no symptoms, but your
blood pressure will go back up if you don't take your medicine. Make your pill
schedule as simple as you can. Plan times to take them when you are doing other
things, like eating a meal or getting ready for bed.
What can you do to
prevent high blood pressure?
There are six lifestyle
changes you can make to help prevent high blood pressure:
- Lose extra weight.
- Eat less salt.
- Limit alcohol to 2 drinks a day for men and 1 drink a
day for women and lighter-weight men.
- Get 3,500 mg of potassium in your diet every day.
Fresh, unprocessed whole foods have the most potassium. These foods
include meat, fish, nonfat and low-fat dairy products, and many fruits and
- Follow the DASH eating plan (Dietary Approaches to Stop
Hypertension). This diet is rich in fruits, vegetables, and low-fat dairy
products and is low in fat.
following published studies conducted at the University UC Davis using the
patented, FDA GRAS recognized MegaNatural® BP grape seed extract have been
Mechanism of the Endothelium-Dependent Relaxation
Evoked by a Grape Seed Extract
Indika EDIRISINGHE, Britt BURTON-FREEMAN and C. Tissa
Department of Internal Medicine, University of California
Davis, Davis, CA 95616, U.S.A., and Department of Nutrition, University of
California Davis, Davis, CA 95616, U.S.A.
GSEs (grape seed extracts) which contain polyphenolic
compounds cause an endothelium-dependent relaxation of blood vessels. The aim
of the present study was to examine the
mechanisms involved in this response. A well-characterized GSE was applied to
rabbit aortic rings suspended in organ baths containing Krebs–Henseleit buffer
maintained at 37 C. In aortic rings pre-contacted with noradrenaline
(norepinephrine), the extract produced a dose-dependent relaxation. The maximum
relaxations elicited by the extract (71.9+- 1.0%) were similar to those
elicited by acetylcholine (64.2+- 1.5%) (n=12 for each). As expected, the
relaxations were abolished by removal of the endothelium and by prior
incubation with L-NAME (NG-nitro-L-Arginine methyl ester), confirming the
essential role of eNOS (endothelial NO synthase) in the response. The responses
to the GSE were also abolished by incubation with wortmannin and LY294002,
which are inhibitors of PI3K (phosphoinositide 3-kinase). These compounds had
no effect on the responses to acetylcholine. Using immunoblotting, we also
demonstrated that the GSE induced the phosphorylation of both Akt and eNOS in
HUVECs (human umbilical vein endothelial cells). Finally, the extract was
modified by methylation of the hydroxy groups in the polyphenolic groups and
was applied to the aortic rings. The modified extract failed to cause a
relaxation. Taken together, these findings suggest that the
endothelium-dependent relaxation induced by the GSE was mediated by activation
of the PI3K/Akt signaling pathway through a redox-sensitive mechanism,
resulting in phosphorylation of eNOS.
Effect of Grape Seed Extract on Blood
Pressure in Subjects with Metabolic Syndrome.
Brahmesh Sivaprakasapillaia, Indika Edirisingheb, Jody
Randolphc,Francene Steinbergc, Tissa Kappagodaa
Department of Internal Medicine, University of California
Davis, Davis, CA 95616, USA
National Center for Food Safety and Technology, Illinois
Institute of Technology, Moffet Campus, Summit-Argo, IL 60501, USA
Department of Nutrition, University of California Davis,
Davis, CA 95616, USA
Received 21 November 2008; accepted 29 May 2009
This study was undertaken to determine whether grape seed
extracts (GSE) that contain powerful vasodilator phenolic compounds lower blood
pressure in subjects with the metabolic syndrome. The subjects were randomized
into 3 groups—(a) placebo, (b) 150 mg GSE per day, and (c) 300 mg GSE per
day—and treated for 4 weeks. Serum lipids and blood glucose were measured at
the beginning of the study and at the end. Blood pressure was recorded using an
ambulatory monitoring device at the start of the treatment period and at the
end. Both the systolic and diastolic blood pressures were lowered after
treatment with GSE as compared with placebo. There were no significant changes
in serum lipids or blood glucose values. These findings suggest that GSE could
be used as a nutraceutical in a lifestyle modification program for patients with
the metabolic syndrome.
Blood Pressure Support, let us help you get your blood pressure in line. MegaNatural®-BP™ contains flavonoids that can
support healthy arterial function already within the healthy range through a
number of mechanisms.
Vitamins product exceeds the standards and requirements set forth in the FDA’s
Code of Federal Regulation (21 CFR, 111) Current Good Manufacturing Practices
in the USA, with ALL USA Ingredients!
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*Disclaimer: None of the above statements have been evaluated by the FDA. These
products are not intended to diagnose, treat, cure or prevent any disease. As
always, consult your physician before taking any and all supplements.
LifeSource Vitamins. Individual results may vary.
Disclaimer: All the information contained throughout this website is based upon the
opinion of the founder of LifeSource Vitamins Bruce Brightman, and the entire
team at LifeSource Vitamins whose relentless research and studies have been
ongoing on since 1992. Other articles
and information are based on the opinions of the authors, who retains the
copyright as marked on the article. The
information on this site is not intended to replace your health care
professional, but to enhance your relationship with them. Doing your own studying and research and
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partnership with your health care professional.
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