Emerging evidence indicates that the role of Grape Seed Extract (GSE) in
support of cardiovascular health may extend beyond its important
antioxidant functions. Scientific studies have shown that the proprietary
GSE found in LifeSource Vitamins Blood Pressure Support, MegaNatural®-BP™ contains flavonoids that can support
healthy arterial function already within the healthy range through a number
of mechanisms. In fact, these studies suggest that MegaNatural®-BP™ can help maintain blood pressure already
within the healthy range. In addition, we have included a standardized
Hawthorn Extract as a synergist. Hawthorn Extract provides powerful
antioxidant flavonoids, including standardized Vitexin that, along with
other components in Hawthorn, have also been found to support healthy range
blood flow and healthy range blood pressure.*
- Cardiovascular Support*
- Helps maintain blood pressure already within the healthy range*
- May help people with pre-hypertension manage their condition*
- Can help suppress inflammation*
- Vegetarian Formula
- Grape Seed Extract - MegaNatural®-BP™ w/ Hawthorn Berry
Why Does LifeSource Vitamins use MegaNatural®-BP™?
is made in California from a special seed blend primarily from varietal
white wine grapes. The seeds are extracted with hot water, the extract is
purified, concentrated and spray dried, loading natural grape phenolics
into the extract, and that extract powder is used as an ingredient for
dietary supplements, functional foods, and healthy beverages.
is a patented grape seed extract that has been evaluated in human clinical
studies at the UC Davis Department of Internal Medicine. Studies evaluated
subjects with blood pressure levels in the normal to pre-hypertensive
ranges. One clinical, involving patients with Metabolic Syndrome, showed
incidental blood pressure reductions, averaging 12 mmHg for systolic and 8
mmHg for diastolic pressures. In another study, participants with
pre-hypertension took 300 mg of MegaNatural®-BP™ once a
day for two months, and blood pressure monitoring averaged in systolic
readings 8 mmHg lower and diastolic pressure lower by 5 mmHg. These studies
indicate that MegaNatural®-BP™ may offer a significant
benefit for people with technically healthy blood pressure that typically
ranges on the upper end of normal, a condition known as “pre-hypertension.”
is a distinct form of grape seed extract in that it is backed by human
clinical research, which is rare in the industry. It is also supported by a
portfolio of intellectual property, including a trademarked brand name and
manufacturing and usage patents, further differentiating it from other
commodity grape seed extracts. The ingredient fills a need for a natural,
effective solution to common health concerns, such as high blood pressure,
and is attractive to those seeking a solution without the side effects
associated with pharmaceutical drugs. MegaNatural®-BP™ has
achieved FDA No-Objection GRAS status, making it safe.
is rich in polyphenolic substances, which are known vasodilators. In a UC
Davis human clinical study, patients taking 300 mg of MegaNatural®-BP™ daily for 8 weeks showed an 8 mm drop in
systolic pressure verses zero for those in a placebo group. When taken
twice daily, LifeSource Vitamins Blood Pressure Support contains the
recommended 300 mg of
It is estimated that 60 million Americans have high blood pressure, and uncontrolled high blood pressure (hypertension) is the leading risk factor
for both heart attack and stroke. Women are even more vulnerable to high
blood pressure than men. Despite lifestyle modifications and drugs, only about two-thirds of those who know they have high blood pressure have it
under control (usually with drugs). These statistics make high blood
pressure the number one concern of cardiologists and internists today.
Blood pressure is the result of a complex system that includes not only the
heart and blood vessels but also hormones and protein messengers. As the heart pumps, it sends blood through arteries. Healthy arteries expand under
the pressure and contract when the pressure wave passes. However, unhealthy or inelastic arteries cannot expand, which causes higher pressure when the blood pumps.
Receptors in the kidneys keep track of pressure and send hormone signals to
the heart to speed up or slow down as needed.
LifeSource Vitamins Blood Pressure Support helps to maintain blood pressure
already within the healthy range MegaNatural®-BP™ is a patented grape seed
extract that has been evaluated in human clinical studies at the UC Davis
Department of Internal Medicine. Made in California under stringent
Why did LifeSource Vitamins add Hawthorn Extract to our Blood Pressure
Hawthorn is a common thorny shrub in the rose family that grows up to 5
feet tall on hillsides and in sunny wooded areas throughout the world. Its
flowers bloom in May. They grow in small white, red, or pink clusters.
Small berries, called haws, sprout after the flowers. They are usually red
when ripe, but they may also be black. Hawthorn leaves are shiny and grow
in a variety of shapes and sizes.
What's It Made Of?
Hawthorn contains many substances that may benefit the heart. These
antioxidant flavonoids -- including OPCs -- may help dilate blood vessels,
improve blood flow, and protect the blood vessels from damage.
The berries, leaves, and flowers of the hawthorn plant have been used for
medicinal purposes. Most modern preparations use the leaves and flowers,
which are believed to contain more of the flavonoids than the berries.
Medicinal Uses and Indications
Hawthorn is used to help protect against heart disease and
help control high blood pressure and high cholesterol.
Both animal and human studies suggest hawthorn increases coronary artery
blood flow, improves circulation, and lowers blood pressure. It has also
been used on the skin to treat boils and skin sores.
Hawthorn has been studied in people with heart failure (a condition in
which the heart is unable to pump enough blood to other organs in the
body), but more studies are needed to understand how effective it may be. A
number of studies conclude that hawthorn significantly improved heart
function. Studies also suggest the herb can enhance a person's ability to
exercise following heart failure. Participants in studies have reported
that hawthorn significantly improved symptoms of the disease (such as
shortness of breath and fatigue). One study found that hawthorn extract
(900 mg/day) taken for 2 months was as effective as low doses of captopril
(a prescription heart medication) in improving symptoms of heart failure.
A large study found that a standardized hawthorn supplement was effective
in 952 patients with heart failure. The study compared conventional methods
of treating heart failure (with different medications) with hawthorn alone
and in addition to the drugs. After 2 years, the clinical symptoms of heart
failure (palpitations, breathing problems, and fatigue) decreased
significantly in the patients taking the hawthorn supplement. People taking
hawthorn also took less medication for their condition.
Heart failure is a serious condition, and you should never try to
self-treat with hawthorn. Ask your doctor if hawthorn is right for you.
Chest pain (Angina)
Preliminary evidence suggests hawthorn may help combat chest pain (angina),
which is caused by low blood flow to the heart. In one early study, 60
people with angina were given either 180 mg/day of hawthorn berry leaf
flower extract or placebo for 3 weeks. Those who received hawthorn
experienced improved blood flow to the heart and were also able to exercise
for longer periods of time without suffering from chest pain. However, more
studies are needed to say for sure whether hawthorn is effective.
High blood pressure
Although hawthorn has not been studied specifically in people with high
blood pressure, some people think its benefits in treating heart disease
may carry over to treating high blood pressure (hypertension). However, so
far not enough research has been done to say whether hawthorn is effective
at lowering blood pressure -- and if so, by how much.
In one study, hawthorn extract was found to be effective for hypertension
in people with type 2 diabetes who were also taking prescribed medicines.
Participants took 1,200 mg hawthorn extract daily or placebo for 16 weeks.
Those taking hawthorn had lower blood pressure than those taking the
You should talk to your doctor before taking hawthorn if you have high
See Blood Pressure Conditions and Cures Information:
Articles on Blood Pressure:
See All LifeSource Vitamins Blood Pressure Products, Articles, and
University of Maryland Medical Center
What is high blood pressure?
Blood pressure is a measure of how hard the blood pushes against the walls
of your arteries as it moves through your body. It's normal for blood
pressure to go up and down throughout the day, but if it stays up, you have
high blood pressure. Another name for high blood pressure is hypertension.
When blood pressure is high, it starts to damage the blood vessels, heart,
and kidneys. This can lead to heart attack, stroke, and other problems.
High blood pressure is called a "silent killer,'' because it doesn't
usually cause symptoms while it is causing this damage.
Your blood pressure consists of two numbers: systolic and diastolic.
Someone with a systolic pressure of 120 and a diastolic pressure of 80 has
a blood pressure of 120/80, or "120 over 80."
The systolic number shows how hard the blood pushes when the heart is
· The diastolic number shows how hard the blood pushes between heartbeats
when the heart is relaxed and filling with blood.
Adults should have a blood pressure of less than 120/80. High blood
pressure is 140/90 or higher. Many people fall into the category in
between, called prehypertension. People with pre-hypertension need to make
lifestyle changes to bring the blood pressure down and help prevent or
delay high blood pressure.
What causes high blood pressure?
In most cases, doctors can't point to the exact cause, but several things
are known to raise blood pressure; being very overweight, drinking too much
alcohol, having a family history of high blood pressure, eating too much
salt, and getting older. Your blood pressure may also rise if you are not
very active, you don't eat enough potassium and calcium, or you have a
condition called insulin resistance.
What are the symptoms?
High blood pressure does not usually cause symptoms. Most people don't know
they have it until they go to the doctor for some other reason.
Without treatment, high blood pressure can damage the heart, brain,
kidneys, or eyes. This damage causes problems like coronary artery disease,
stroke, and kidney failure.
Very high blood pressure can cause headaches, vision problems, nausea, and
vomiting. Malignant high blood pressure (hypertensive crisis), which is
blood pressure that rises very fast, can also cause these symptoms.
Malignant high blood pressure is a medical emergency.
How is high blood pressure diagnosed?
Most people find out they have high blood pressure during a routine doctor
visit. For your doctor to confirm that you have high blood pressure, your
blood pressure must be at least 140/90 on three or more separate occasions.
It is usually measured 1 to 2 weeks apart.
You may have to check your blood pressure at home if there is a reason to
think the readings in the doctor's office are not accurate. You may have
what is called white-coat hypertension, which is blood pressure that goes
up just because you're at the doctor's office. Even routine activities,
such as attending a meeting, can raise your blood pressure. So can
commuting to work or smoking a cigarette.
How is it treated?
Treatment depends on how high your blood pressure is, whether you have
other health problems such as diabetes and whether any organs have already
been damaged. Your doctor will also consider how likely you are to develop
other diseases, especially heart disease.
You can help lower your blood pressure by making healthy changes in your
lifestyle. If those lifestyle changes don't work, you may also need to take
pills. Either way, you will need to control your high blood pressure
throughout your life.
- If you have pre-hypertension, your doctor will likely recommend lifestyle
changes. This may include losing extra weight, exercising, limiting
alcohol, cutting back on salt, quitting smoking, and eating a low-fat diet
that includes more fruits, vegetables, whole grains, and low-fat dairy
- If you have high blood pressure without any organ damage or other risk
factors for heart disease, your doctor may recommend that you take medicine
in addition to making lifestyle changes.
- If you have high blood pressure and have some organ damage or other risk
factors for heart disease, you may need to try various combinations of
medicines in addition to making big lifestyle changes.
Most people take more than one pill for high blood pressure. Work with your
doctor to find the right pill or combination of pills that will cause the
fewest side effects.
It can be hard to remember to take pills when you have no symptoms, but
your blood pressure will go back up if you don't take your medicine. Make
your pill schedule as simple as you can. Plan times to take them when you
are doing other things, like eating a meal or getting ready for bed.
What can you do to prevent high blood pressure?
There are six lifestyle changes you can make to help prevent high blood
Lose extra weight.
Eat less salt.
· Limit alcohol to 2 drinks a day for men and 1 drink a day for women and
· Get 3,500 mg of potassium in your diet every day. Fresh, unprocessed
whole foods have the most potassium. These foods include meat, fish, nonfat
and low-fat dairy products, and many fruits and vegetables.
· Follow the DASH eating plan (Dietary Approaches to Stop Hypertension).
This diet is rich in fruits, vegetables, and low-fat dairy products and is
low in fat.
The following published studies conducted at the University UC Davis
using the patented, FDA GRAS recognized MegaNatural® BP grape seed
extract has been attached.
Mechanism of the Endothelium-Dependent Relaxation
Evoked by a Grape Seed Extract
Indika EDIRISINGHE, Britt BURTON-FREEMAN and C. Tissa KAPPAGODA
Department of Internal Medicine, University of California Davis, Davis, CA
95616, U.S.A., and Department of Nutrition, University of California Davis,
Davis, CA 95616, U.S.A.
GSEs (grape seed extracts) which contain polyphenolic compounds cause an
endothelium-dependent relaxation of blood vessels. The aim of the present
study was to examine the mechanisms involved in this response. A
well-characterized GSE was applied to rabbit aortic rings suspended in
organ baths containing Krebs–Henseleit buffer maintained at 37 C. In aortic
rings pre-contacted with noradrenaline (norepinephrine), the extract
produced a dose-dependent relaxation. The maximum relaxations elicited by
the extract (71.9+- 1.0%) were similar to those elicited by acetylcholine
(64.2+- 1.5%) (n=12 for each). As expected, the relaxations were abolished
by removal of the endothelium and by prior incubation with L-NAME
(NG-nitro-L-Arginine methyl ester), confirming the essential role of eNOS
(endothelial NO synthase) in the response. The responses to the GSE were
also abolished by incubation with wortmannin and LY294002, which are
inhibitors of PI3K (phosphoinositide 3-kinase). These compounds had no
effect on the responses to acetylcholine. Using immunoblotting, we also
demonstrated that the GSE induced the phosphorylation of both Akt and eNOS
in HUVECs (human umbilical vein endothelial cells). Finally, the extract
was modified by methylation of the hydroxy groups in the polyphenolic
groups and was applied to the aortic rings. The modified extract failed to
cause a relaxation. Taken together, these findings suggest that the
endothelium-dependent relaxation induced by the GSE was mediated by
activation of the PI3K/Akt signaling pathway through a redox-sensitive
mechanism, resulting in phosphorylation of eNOS.
Effect of Grape Seed Extract on Blood Pressure in Subjects with
Brahmesh Sivaprakasapillaia, Indika Edirisingheb, Jody Randolphc,Francene
Steinbergc, Tissa Kappagodaa
Department of Internal Medicine, University of California Davis, Davis, CA
National Center for Food Safety and Technology, Illinois Institute of
Technology, Moffet Campus, Summit-Argo, IL 60501, USA
Department of Nutrition, University of California Davis, Davis, CA 95616,
Received 21 November 2008; accepted 29 May 2009
This study was undertaken to determine whether grape seed extracts (GSE)
that contain powerful vasodilator phenolic compounds lower blood pressure
in subjects with the metabolic syndrome. The subjects were randomized into
3 groups—(a) placebo, (b) 150 mg GSE per day, and (c) 300 mg GSE per
day—and treated for 4 weeks. Serum lipids and blood glucose were measured
at the beginning of the study and at the end. Blood pressure was recorded
using an ambulatory monitoring device at the start of the treatment period
and at the end. Both the systolic and diastolic blood pressures were
lowered after treatment with GSE as compared with placebo. There were no
significant changes in serum lipids or blood glucose values. These findings
suggest that GSE could be used as a nutraceutical in a lifestyle
modification program for patients with metabolic syndrome.
LifeSource Vitamins Blood Pressure Support, let us help you get your blood
pressure in line. MegaNatural®-BP™ contains flavonoids that can support
healthy arterial function already within the healthy range through a number
Every LifeSource Vitamins product exceeds all regulation standards and
requirements set forth in the FDA’s
Code of Federal Regulation
as well as all Good Manufacturing Practices enforced by the FDA called
. CGMP’s provide for systems that assure proper design, monitoring, and
control of manufacturing processes and facilities.
FDA Codes of Regulations: (
21 CFR, part 111 ) / CGMP Codes of Regulations: (
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are not intended to diagnose, treat, cure or prevent any disease.
As always, consult your physician before taking any and all
LifeSource Vitamins. Individual results may vary.
All the information contained throughout this website is based upon the
opinions of the founder of LifeSource Vitamins, Bruce Brightman, and the
entire team at LifeSource Vitamins whose relentless research and studies
have been ongoing since 1992. Other articles and information are based on
the opinions of the authors, who retain the copyright as marked in the
article. The information on this site is not intended to replace your
health care professional, but to enhance your relationship with them. Doing
your own studying and research and taking your health care into your own
hands is always best, especially in partnership with your health care
If you are pregnant, nursing, taking medications, or have any medical
conditions, always consult your health care professional before taking
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