& Niacin w/ Vit C - Studies & Information
These Two Vitamins have been shown helpful for Schzophrenia.
subset of schizophrenia – a therapeutic review
It is well
known that niacin deficiency manifests with several psychiatric manifestations.
Also, historically evidence has accumulated that niacin augmentation can be
used for the treatment of schizophrenia. However, the etiopathological associations
between niacin deficiency and schizophrenia as well as the mechanism of action
of niacin in its treatment. More importantly, the subgroups of schizophrenia
that will respond to niacin augmentation have never been highlighted in the
literature. In this article, we review three of the mechanisms in which niacin
deficiency could lead to schizophrenic symptoms: (1) Niacin deficiency
neurodegeneration (2) Membrane phospholipid deficiency hypothesis, and (3)
Adrenochrome hypothesis. We will further move towards the clinical as well as
treatment-related associations as reviewed from the literature. Here, we
propose a model that a subset of schizophrenia can respond to niacin
augmentation therapy better than other subsets because these patients have contributions
in their psychotic manifestations from the neural degeneration resulting from
niacin deficiency. We present a short description of our case report which
showed rapid improvement in schizophrenic psychotic symptoms subsequent to
administration of niacin as an augmentation therapy. We, thus, propose that
niacin deficiency is a contributory factor in schizophrenia development in some
patients and symptom alleviation in these patients will benefit from niacin
augmentation, especially in some particular psychotic features. National Institute of Health PubMed
a possible successful treatment for schizophrenia?
Schizophrenia is a devastating disease.
Characterized by hallucinations, delusions, and disorganized thought, it
destroys lives. While the condition can be controlled with appropriate
medication, a cure remains elusive. But just what constitutes “appropriate
medication” is controversial.
Schizophrenia is a devastating disease. Characterized by
hallucinations, delusions, and disorganized thought, it destroys lives. While
the condition can be controlled with appropriate medication, a cure remains
elusive. But just what constitutes “appropriate medication” is controversial.
“Antipsychotic drugs that block dopamine and serotonin receptors in the brain
have been the mainstay of therapy, but the involuntary muscle movements,
restlessness, and tremors they can cause are troublesome. An alternative school
of thought maintains that mental illness can be addressed with nutritional
therapies, particularly with the use of certain vitamins in the right dose.
This idea was first formulated by Dr. Abram Hoffer, a Canadian psychiatrist
whose pursuit of science began with a degree in agricultural chemistry from The University of Saskatchewan, followed by a Ph.D. in biochemistry, and finally a
medical degree from the University of Alberta. During his graduate studies, young Hoffer worked at a wheat products laboratory in Winnipeg where he was
charged with developing an assay for vitamin B-3, commonly known as niacin.
This triggered a life-long interest in the vitamin and its biochemistry, with
Hoffer eventually concluding that it had a significant role to play in the
treatment of schizophrenia. As a practicing psychiatrist, Dr. Hoffer came up
with the ‘adrenochrome hypothesis’ which he believed explained the symptoms of
schizophrenia and offered hope for treatment with vitamins.
Hoffer’s basic idea was that schizophrenia was a biochemical abnormality
characterized by the buildup of chemicals in the brain called adrenochromes.
These are normally formed from adrenalin, but in a healthy nervous system, they
are quickly metabolized. In schizophrenic patients, however, the mechanism for
breaking down adrenochromes is impaired. Hoffer claimed that administering
adrenochromes to volunteers resulted in hallucinations reminiscent of
schizophrenia and hypothesized that reducing adrenochrome concentrations in
schizophrenic patients would result in the alleviation of symptoms. From his
biochemistry background, he knew that niacin could reduce the formation of
adrenalin from its precursor, noradrenalin, which meant it would also reduce
adrenochromes since these were made from adrenalin. He also rationalized that
adrenochromes could be reduced back to adrenaline through the administration of
in the 1950’s Dr. Hoffer began to administer high doses of niacin and vitamin C
to his schizophrenic patients and claimed he noted an improvement after a
month. Paranoia and delusional symptoms decreased to an extent that
hospitalized patients could be discharged. But, Hoffer maintained that if they
stopped taking the vitamins they would experience a relapse. However, if they
continued with the regimen for years, there was a chance of a complete cure.
The problem, though, was that other researchers were unable to confirm Hoffer’s
successes, resulting in skepticism about his claims. Interestingly, subsequent
research did show that schizophrenic patients have a genetic defect preventing
them from successfully eliminating adrenaline metabolites, so the adrenochrome
theory is not ready to be dismissed. Still, we are left with the fact that no
properly controlled clinical trials have demonstrated significant benefits of
vitamin megadoses in schizophrenia. That’s not a great surprise because
schizophrenia is a complex disease, not characterized by a single cause.
Genetic vulnerability, as well as environmental effects, are significant factors
and lack of oxygen just after birth may also play a role.
some psychiatrists continue to administer megadoses of niacin to schizophrenia
patients and claim they see improvement. But such evidence is anecdotal.
Perhaps further research will reveal that some vitamins used appropriately are
beneficial, but for now, the evidence is on the side of using mainstream
antipsychotic medications. It certainly is unwise for patients to try
megavitamin therapy without a physician’s supervision. While doses of niacin
under 1,000 mg are considered safe, higher doses can cause liver damage,
gastritis, diabetes, and an increase in blood uric acid levels. McGill
Office for Science and Society
Niacin combined with Vitamin C seems to help those in need.*
Niacin: 500mg first 2 weeks, then 1,000mg daily
Vitamin C: 1,000mg first 2 weeks, then 2,000mg daily
Niacin Flush Free – Click
Vitamin C Supplements – Click
Proudly Made in the USA!
Every LifeSource Vitamins product exceeds all regulation standards and requirements set forth in the FDA's Code of Federal Regulation. ( 21 CFR, part 111 ) as well as all Good Manufacturing Practices enforced by the FDA. CGMP's provide for systems that assure proper design, monitoring, and control of manufacturing processes and facilities. ( CGMP ).
LifeSource Vitamins: Driven by Faith ~ Powered by God
Have Questions on this or any other product or health issue for you or a loved one? It can be overwhelming we know. Call us, we will walk you through what supplements will help you and which ones you really don’t need. It’s what we do! Toll-Free: 800-567-8122
LifeSource Vitamins – Founded in 1992
100% of our profits are donated to Christian Organizations like these and many others worldwide:
Campus Crusade for Christ - CRU
The Jesus Film Project
The Tim Tebow Foundation
The Herman and Sharron Show on CTN (Christian Television Network) and many more…
E-mail Us: info@LifesourceVitamins.com
or Call Us: 800.567.8122
We Are Built on Compassion - Driven by Faith & Powered by God!
*Disclaimer: None of the above statements have been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease. As always, consult your physician before taking any and all supplements. LifeSource Vitamins. Individual results may vary.
Disclaimer: All the information contained throughout this website is based upon the opinions of the founder of LifeSource Vitamins, Bruce Brightman, and the entire team at LifeSource Vitamins whose relentless research and studies have been ongoing since 1992. Other articles and information are based on the opinions of the authors, who retain the copyright as marked in the article. The information on this site is not intended to replace your health care professional, but to enhance your relationship with them. Doing your own studying and research and taking your health care into your own hands is always best, especially in partnership with your health care professional.
If you are pregnant, nursing, taking medications, or have any medical conditions, always consult your health care professional before taking supplements based on the information on this site.
LifeSource Vitamins: from the nutrients we choose, to the way we run our business, we answer to God in all we do!
Supplements shown helpful for Schizophrenia
Vitamins Showing Promise for Schizophrenia
Nutrients shown to help with Schizophrenia
These Two Vitamins have been shown helpful for Schzophrenia.