In human beings,
vitamin E is the most important fat-soluble antioxidant. It prevents the
potentially harmful oxidation of fat compounds and enhances the functioning of
vitamin A. It is an anti-pollutant for the lungs. It helps the healing of scar
tissue when taken internally and also when applied externally.
The best natural
sources are wheat germ, whole grains, vegetable oils, soya beans, nuts, apples,
apricots and green vegetables.
Vitamin E deficiency
may cause anemia, as a result of red blood cell destruction and neurological
dysfunction, myopathies, and diminished erythrocyte life span. New clinical
evidence from heavy drinkers suggests that alcohol may increase oxidation of
Alpha-Tocopherol. Increased demand has also been observed in premature infants
and patients with malabsorption.
Your best bet for a
good blend of mixed tocopherols in a softgel form is LifeSource Vitamins
Vitamin E with 20% Mixed Tocopherols.
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Current Research on
Photo-protective Effects: Tocopherol may play an
essential role in the defense of eye and skin cells against many light-induced
diseases and/or conditions. Vitamin E may share a protective role in the
membranes of plant and animal cells that are naturally predisposed to
photo-oxidative stress. It may play a prophylactic role against diseases and
conditions of the eye (cataractogenesis and retinal photodeterioration) and
skin (erythrocyte photochemolysis, photoerythema, photoaging and
UV radiation can
cause adverse effects such as sunburn, immunologic suppression, photo-aging,
skin tumors, and photosensitivity reactions. In a study looking at protective
effects of vitamin C and vitamin E against sunburn, researchers found combined
vitamins C and E reduced sunburn reaction. It was concluded that this might
help reduce the risk for later UV-induced skin damage.
Crohn's Disease and Short Bowel Syndrome: Vitamin E deficiency can
result from malabsorption of the vitamin due to fat malabsorption resulting
from Crohn's disease with short-bowel syndrome.
A study reported in the American Journal of Clinical Nutrition showed that
vitamin E preparations may aid in intestinal absorption of vitamin E in
short-bowel syndrome. The study also showed that vitamin E supplementation may
help stem and allow for a partial reversal of the neurologic complications seen
with vitamin E deficiency.
Heart Disease: Vitamin E may play a crucial role in the
pathogenesis of atherosclerosis. The hypothesis is that vitamin E helps
protects against the oxidation of unsaturated lipids in the low-density
lipoprotein (LDL) particle that initiates a complex sequence of events leading
to atherosclerotic plaque.
dietary vitamin E concentrations may be associated with a lower risk of stroke.
In a study done in 2000, vitamin E supplementation decreased the risk of
cerebral infarction, without elevating the risk of subarachnoid hemorrhage. The
authors concluded that vitamin E supplementation may help prevent ischemic
stroke in high-risk hypertensive patients, although further studies are needed.
Alzheimer's Disease and Dementia: There is
increased oxidative damage in the brain of Alzheimer's disease (AD) patients
and excess of free radicals. Vitamin E can prevent free-radical-mediated cell
death and possibly diminish cognitive deterioration. The results of a clinical
trial in 2000 showed that treatment with vitamin E delayed the time to
important functional endpoints. It suggested that vitamin E may slow the
disease progression in moderately advanced AD patients.
The use of vitamin C and E supplements may protect against the development of
dementia and poor cognitive functioning. Results from a study on dementia in
elderly men suggested that vitamins E and C might protect against vascular
dementia and possibly enhance cognitive function later in life.
Diabetes: Individuals with low vitamin E concentrations may be
at greater risk for insulin-dependent diabetes mellitus (IDDM). In 1999, a
study published in the Journal of Internal Medicine found an inverse
association between serum a-tocopherol concentration and occurrence of IDDM.
Therefore, vitamin E may provide protection against IDDM, which supports the hypothesis that antioxidants may play a crucial role in the pathogenesis of
Type 2 diabetes is associated with increased oxidative stress, which is related
to an imbalance in the cardiac autonomic nervous system. Antioxidants, such as
vitamin E may have beneficial effects on the cardiac autonomic nervous system.
A study on patients diagnosed with type 2 diabetes and cardiac autonomic
neuropathy showed that 600-mg/d vitamin E administration for 4 months was
associated with decreased plasma concentrations of glycated hemoglobin,
insulin, norepinephrine, and epinephrine. Vitamin E also improved indexes of
oxidative stress. Researchers concluded that chronic vitamin E administration
improved the ratio of cardiac sympathetic to parasympathetic tone in patients
with type 2 diabetes.
Immune System: Vitamin E
acts as an antioxidant and can assist in the modulation of the immune system. A
study investigated the immunologic and antioxidant effects of vitamin E
supplementation in healthy Chinese men and women. The data showed elevated
plasma vitamin E concentrations and depression in plasma malondialdehyde and
urinary DNA adduct 8-hydroxy-2'-deoxyguanosine. The oxidative stress of
T-lymphocyte is lowered significantly by vitamin E supplementation. Since it is
known that high levels of oxidative stress such as H2O2 inhibited T-cell
proliferation, this suggests that vitamin E has an important role in immune
studies show a protective role of vitamins as antioxidants in the prevention of
age-related cataracts and macular degeneration. In a review of 11 studies, 8
studies found vitamin E was inversely correlated with cataract risk. Based on
the observations, researchers concluded that a diet high in vitamins C, E, and
carotenoids, may aid in decreasing the development of cataracts and age-related
Steatohepatitis in Children: A study was done looking at the effects of vitamin E in
lowering serum aminotransferase and alkaline phosphatase concentrations in
children with nonalcoholic steatohepatitis (NASH) that is associated with
obesity. The a-tocopherol concentrations increased significantly with vitamin E
supplementation and the serum aminotransferase and alkaline phosphatase
concentrations normalized. Researchers concluded that children with NASH should
be encouraged to be involved in a weight loss regimen and consider taking
Vitamin E: Natural and synthetic forms of a-tocopherol have been shown to
be absorbed equally well. A study giving subjects various doses of natural and
synthetic vitamin E showed significantly less oxidation of low-density
lipoprotein cholesterol (LDL-C) in the subjects given either form of 400 or 800
IU of vitamin E. Researchers concluded that both natural and synthetic forms of
vitamin E are as effective inhibiting the oxidation of LDL-C in humans. However
natural is always the best way to get absorption into your bloodstream.
LifeSource Vitamins - Vitamin E 400 IU, 100 softgels, most
important fat-soluble antioxidant prevents the potentially harmful oxidation
of fat compounds, enhances the functioning of vitamin A, helps the healing of