Prostaplex Plus β Tablets, 90 Count - Supports Urinary Flow, Nighttime Comfort & Prostate Health* 26 Ingredients.
LifeSource Vitamins Prostaplex Plus combines beta-sitosterol, stinging nettle root, pygeum, pumpkin seed, and supportive nutrients to help maintain healthy urinary flow, nighttime comfort, and overall prostate wellness. Produced in FDA-registered, GMP-certified facilities and
3rd-party tested for identity, potency & purity.*
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. In addition, we reference reviews from 39 leading health organizations and insights from 20 top global universities to ensure our guidance aligns with credible science.*
Clinically Studied Benefits (with research)
β’ Helps ease urinary symptoms β Multiple randomized, placebo-controlled trials show beta-sitosterol improves LUTS/IPSS and peak flow in men with BPH. (NIH/PubMed β Berges, 1995; NIH/PubMed β Berges, 2000 (18-mo follow-up))
β’ Consistent evidence from systematic reviews β SRs conclude non-glucosidic Ξ²-sitosterols improve urinary symptoms and flow measures (long-term data still limited). (NIH/PubMed β Wilt, 1999; PMC β Wilt (review), 1999)
β’ Pygeum may reduce LUTS β Meta-analyses of clinical trials report Pygeum africanum improved nocturia and peak flow versus placebo, though studies are older and short-term. (NIH/PubMed β Ishani, 2000; PMC β Wilt, 1998)
β’ Stinging nettle root supports symptom relief β A 1-year, randomized, double-blind, placebo-controlled trial of nettle root extract significantly improved IPSS vs placebo. (NIH/PubMed β Schneider, 2004)
β’ Pumpkin seed for LUTS comfort β RCTs in men with BPH/LUTS reported clinically relevant IPSS reductions and symptomatic benefits with pumpkin seed interventions. (NIH/PubMed β Vahlensieck, 2015; PMC β Leibbrand, 2019)
β’ Saw palmetto: evidence is mixed β Some earlier RCTs saw symptom benefits, but large, rigorous trials (including dose-escalation) found no improvement over placebo. (NIH/PubMed β Gerber, 2001; PMC β Barry, 2011; NIH/PubMed β Bent/NEJM, 2006)
β’ Beta-sitosterol remains a leading botanical β Contemporary review confirms Ξ²-sitosterol improves IPSS, QoL, post-void residuals vs placebo (not prostate volume). (PMC β Macoska, 2023)
β’ Combination evidence varies β A trial of low-dose pygeum + nettle did not outperform placebo, underscoring the importance of dose/standardization. (NIH/PubMed β Melo, 2002)
β’ Safety/tolerability β Reviews across phytotherapy agents report generally mild and infrequent adverse effects in BPH studies. (NIH/PubMed β Kim, 2012)
β’ Guideline context β Major systematic reviews conclude Serenoa repens alone provides little to no benefit; Ξ²-sitosterol shows symptomatic improvement. (NIH/PubMed β Tacklind/Cochrane, 2012; NIH/PubMed β Wilt, 1999)
Additional Studies Showing Promising Benefits*
β’ Nettle root evidence base β Narrative and clinical reviews note anti-inflammatory/anti-androgenic actions; some RCTs with proprietary extracts improved BPH complaints. (NIH/PubMed β Chrubasik, 2007)
β’ Pumpkin seed oil vs tamsulosin β Both reduced IPSS over 3 months; decreases were larger with tamsulosin, with similar 1β3 month slope. (PMC β Zerafatjou, 2021)
β’ ODS/NCCIH context β National resources summarize botanical safety/usage for menβs health, complementing clinical data. (NCCIH Spotlight, 2024)
β’ Older pygeum trials β Multicenter, double-blind trials reported improvements vs placebo over 60 days; heterogeneity/short duration noted. (NIH/PubMed β Barlet, 1990)
β’ Saw palmetto research landscape β Mixed; dose-escalation trial up to 3Γ standard dose showed no benefit vs placebo. (PMC β Barry, 2011)
β’ Dietary supplement overview β Review notes significant improvements for Ξ²-sitosterol, pygeum and pollen extract in individual reviews; calls for updated SRs. (NIH/PubMed β Kim, 2012)
University Studies*
β’ Technical University of Munich β RCTs: Ξ²-sitosterol improved IPSS and urinary flow; benefits maintained at 18-month follow-up. (NIH/PubMed β Berges, 1995; NIH/PubMed β Berges, 2000)
β’ Harvard/Massachusetts General Hospital β Dose-escalation RCT up to 960 mg/d saw palmetto showed no advantage vs placebo. (PMC β Barry, 2011)
β’ UCSF/NEJM Collaboration β Large RCT found saw palmetto did not improve symptoms or objective measures vs placebo. (NIH/PubMed β Bent/NEJM, 2006)
β’ University Hospitals Bonn β 12-month, multicenter, randomized trial: stinging nettle root improved IPSS compared with placebo. (NIH/PubMed β Schneider, 2004)
β’ RWTH Aachen/European centers β Systematic reviews/meta-analyses: pygeum associated with LUTS and flow improvements vs placebo, with caveats on study quality. (NIH/PubMed β Ishani, 2000)
Global Evidence & Authoritative Reviews*
β’ Cochrane β 2012 review of 32 RCTs: Serenoa repens showed little to no benefit for LUTS/BPH, even at higher doses. (NIH/PubMed β Tacklind/Cochrane, 2012)
β’ NCCIH β Provider briefing summarizes evidence and safety profiles for saw palmetto in BPH. (NCCIH Spotlight, 2024)
β’ Evidence synthesis β Reviews highlight symptomatic benefits for Ξ²-sitosterol and pygeum, with calls for modern, longer trials. (NIH/PubMed β Wilt, 1999; NIH/PubMed β Ishani, 2000)
Brief Benefit Bullets
β’ Helps maintain smooth urinary flow*
β’ Nighttime comfort support (fewer sleep disruptions)*
β’ Symptom relief support for frequency, urgency & incomplete emptying*
β’ Synergistic botanicals: Ξ²-sitosterol, nettle, pygeum, pumpkin seed*
β’ Science-first formula, 3rd-party lab tested
Suggested Use
Take 1β2 tablets daily with food, or as directed by your healthcare provider. If you take medications or have a medical condition, consult your physician.*
Product Specifications
β’ Serving Size β 1β2 tablets
β’ Servings Per Container β 90 - 180
β’ Form β Tablets
β’ Free From β Gluten, artificial colors*
β’ Quality β Third-party tested for identity, potency & purity
Perfect For
β’ Men seeking daily support for urinary flow & comfort*
β’ Men looking for research-supported botanicals for prostate health*
β’ Those preferring a stimulant-free formula*
Key Ingredients
Beta-Sitosterol β Plant sterol shown in RCTs to improve symptom scores and urinary flow (does not reduce prostate volume). (NIH/PubMed β Berges, 1995; PMC β Macoska, 2023)
Stinging Nettle Root β Randomized, long-term trial showed significant IPSS improvement vs placebo. (NIH/PubMed β Schneider, 2004)
Pygeum africanum β Meta-analyses report improvements in nocturia and flow; trials are short and heterogeneous. (NIH/PubMed β Ishani, 2000)
Pumpkin Seed β RCTs show clinically relevant reductions in LUTS/IPSS. (NIH/PubMed β Vahlensieck, 2015)
Saw Palmetto β Mixed literature; high-quality RCTs show little to no benefit vs placebo. (NIH/PubMed β Bent/NEJM, 2006)
LifeSource Vitamins β Proudly American β Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Prostaplex Plus - 26 Ingredients - beta-sitosterol, nettle root, pygeum & pumpkin seed to support urinary flow, nighttime comfort & prostate health. Clinically Studied Ingredients β NIH/PubMed*
