Oak & Ivy Spray — Topical Herbal Formula — 2 fl oz (59 mL) — Skin Irritation Relief for Poison Oak • Poison Ivy • Bug Bites • Minor Burns*
LifeSource Vitamins Oak & Ivy Spray pairs time-honored botanicals—Grindelia (gumweed), Witch Hazel and Jewelweed—to cool, dry, and soothe irritated skin after outdoor exposure. External-use formula; ethically wild-harvested Botanicals; produced in FDA-registered, GMP-certified facilities and 3rd-party tested for identity, purity & potency.*
Research-Driven & Verified Product.
Explore the clinical research, ingredient science, and global evidence supporting this product below.
Research Promise:
At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is based on human studies verified by the National Institutes of Health (NIH), a world-leading health authority, plus insights from 39 clinically respected organizations and 20 globally renowned health-focused universities.*
Clinically Studied Benefits
✓ Anti-inflammatory action on skin* — Witch hazel extracts reduced pro-inflammatory signaling and supported skin barrier in keratinocyte models and clinical testing.
NIH/PubMed — Liu X, 2025
NIH/PubMed — Hughes-Formella BJ, 1998
✓ Antioxidant & soothing effects* — Witch hazel review summarizes antioxidant/soothing roles in dermatology.
NIH/PubMed — Piazza S, 2022
✓ Targeted cytokine calming (Grindelia)* — Grindelia squarrosa extract down-regulated IL-1β, TNF-α, IL-6, IL-8 and NF-κB signaling in epithelial cells.
NIH/PubMed — Gierlikowska B, 2021
✓ Traditional poison oak/ivy support* — Ethnopharmacology plus controlled work suggest jewelweed may help after urushiol exposure (prevention focus).
NIH/PubMed — Motz VA, 2012
NIH/PubMed — Motz VA, 2015
Additional / Promising Evidence
✓ Barrier & itch pathways* — Witch hazel bark extract modulated IL-6-linked pathways relevant to atopic/irritant dermatitis.
NIH/PubMed — Piazza S, 2022
✓ NF-κB/TLR-4 signaling* — Grindelia reduced TLR-4 expression and NF-κB p65, supporting anti-inflammatory activity.
NIH/PubMed — Gierlikowska B, 2021
✓ Astringent/cooling relief* — Traditional/monograph evidence for witch hazel’s topical astringent benefits.
NIH/ODS — Health Canada Monograph, 2025
University-Led & Academic Studies
✓ Keratinocyte inflammation models* — Witch hazel extracts reduced IL-6 release and inflammatory responses in human keratinocytes.
NIH/PubMed — Piazza S, 2022
✓ Epithelial cytokine modulation* — Grindelia extract inhibited IL-8/TNF-α/IL-1β/IL-6 in airway epithelial cell lines (mechanism relevant to skin irritation pathways).
NIH/PubMed — Gierlikowska B, 2021
✓ Jewelweed/urushiol* — Controlled prevention-oriented work exploring saponins and rash outcomes.
NIH/PubMed — Motz VA, 2015
Global Evidence & Reviews
✓ ESCOP monograph for Grindelia herba* — Summarizing pharmacology, safety and traditional topical uses including against pruritis in dermatitis.
NIH/ODS — ESCOP Monograph, 2016
✓ Health Canada monograph* — Witch hazel topical as astringent to help heal minor wounds, burns, bruises, irritations and local inflammations.
NIH/ODS — Health Canada NHPID, 2025
✓ Overview of herbal dermatology* — Including historical witch hazel trials vs. hydrocortisone and in dermatitis.
NIH/NCBI — Herbal Treatment for Dermatologic Disorders
We monitor research from leading institutions —
Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge, Oxford, Stanford, Yale, Tufts, University of Florida, Oregon State University – Linus Pauling Institute, Columbia, Cornell, Ohio State — to align with credible science.*
Key Ingredients
- Grindelia (flower)
- Jewelweed (herb)
- Witch Hazel (bark)
- Other Ingredients: Grain alcohol (50–60% by volume), deionized water
Brief Benefit Bullets
- Fast-acting, cooling support for poison oak/ivy discomfort*
- Helps calm redness, itch, and swelling*
- Astringent botanicals that help dry weepy areas*
- Outdoor-friendly spray; ethically wild-harvested herbs*
- Non-synthetic fragrance; 3rd-party tested*
Suggested Use
For external use only. Spray to completely cover affected areas; allow to air-dry. Use 2–3× daily as needed. Avoid eyes, mucosa, and broken skin. Discontinue if irritation develops. Keep out of reach of children. If pregnant, nursing, have sensitive skin, or are under medical care, consult your physician.*
Product Specifications
• Size — 2 fl oz (59 mL)
• Form — Topical spray
• Key Ingredients — Grindelia (flower), Jewelweed (herb), Witch Hazel (bark)
• Other Ingredients — Grain alcohol (50–60% by volume), deionized water
• Free From — Synthetic fragrances, parabens
• Quality — Third-party tested for identity, potency & purity
Perfect For
• Outdoor enthusiasts and families seeking fast, natural skin relief*
• First-aid kits for camping, hiking, yard work*
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Oak & Ivy Spray with grindelia, witch hazel & jewelweed — research-linked botanicals for soothing skin irritation after outdoor exposure. 3rd-party tested quality. Clinically Studied Ingredients — NIH/PubMed!*
