Niacin Flush Free (as Inositol Hexanicotinate) — 250 mg per capsule • 90 Count — B3 Support with Minimal Flushing*
LifeSource Vitamins Niacin Flush Free uses inositol hexanicotinate (IHN), a form traditionally used to provide niacin (vitamin B3) with greatly reduced flushing compared with immediate-release nicotinic acid. Produced in FDA-registered, GMP-certified facilities and 3rd-party tested for identity, purity & potency.*
Research-Driven & Verified Product.
Explore the clinical research, ingredient science, and global evidence supporting this product below.
Research Promise:
At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is based on human studies verified by the National Institutes of Health (NIH), a world-leading health authority, plus insights from 39 clinically respected organizations and 20 globally renowned health-focused universities.*
Clinically Studied Benefits
✓ Flush-minimized B3 option* — Reviews and trials note that inositol hexanicotinate is well tolerated with much less flushing than immediate-release nicotinic acid; patient-reported flushing is minimal with IHN.
NIH/NCBI — Djadjo, 2023
NIH/PMC — Kamanna, 2009
✓ Dyslipidemia: IHN not superior to placebo* — Randomized, placebo-controlled trial (6 weeks) comparing extended-release niacin vs IHN (1,500 mg/day) found IHN showed no lipid improvement and showed no evidence of bioavailability.
NIH/PubMed — Keenan, 2013
✓ “No-flush” products often lack active free niacin* — Clinical review: supplements marketed as “no-flush/flush-free” generally contain minimal or no free, pharmacologically active niacin and therefore lack beneficial lipid-modifying effects.
NIH/PubMed — Backes, 2011
✓ Raynaud’s symptom relief (IHN)* — Double-blind, randomized, placebo-controlled trial (4 g/day IHN) in primary Raynaud’s disease reported fewer/shorter vasospastic attacks vs placebo during winter months.
NIH/PubMed — Sunderland, 1988
✓ Important clarity on IHN vs nicotinic acid* — While nicotinic acid (immediate-release) can modify lipids, modern evidence and head-to-head data indicate inositol hexanicotinate does not reliably improve lipid profiles and may not deliver free niacin in meaningful amounts. Use IHN primarily as a flush-minimized B3 option, not as a lipid therapy.
NIH/ODS — Niacin Fact Sheet, 2024
NIH/PubMed — Keenan, 2013
Additional / Promising Evidence
✓ Niacin physiology* — Vitamin B3 is required to make NAD/NADP coenzymes central to energy metabolism; however, benefits depend on bioavailable niacin.
NIH/NCBI — Peechakara, 2024
NIH/ODS — Niacin Fact Sheet, 2024
✓ Cardiovascular outcome perspective* — Contemporary evidence has limited the role of adding niacin to statins; extended-release nicotinic acid increased adverse events in large trials, underscoring the need for clinical guidance.
NIH/ODS — Niacin Fact Sheet, 2024
University-Led & Academic Studies
✓ Mechanisms of flushing* — Review on niacin’s PGD2-mediated flushing pathway and mitigation strategies.
NIH/PMC — Kamanna, 2009
✓ IHN & bioavailability discussion* — RCT comparing ER niacin vs IHN showed lipid efficacy only with ER niacin and no measurable bioavailability for IHN.
NIH/PubMed — Keenan, 2013
Global Evidence & Reviews
✓ NIH Office of Dietary Supplements (ODS)* — Health professional fact sheet on niacin: role of NAD/NADP, flushing, and contemporary clinical guidance; notes limitations of “no-flush” products.
NIH/ODS — Niacin Fact Sheet, 2024
✓ National Lipid Association / J Clin Lipidol* — Clinical trial report: IHN no better than placebo for lipids; no bioavailability detected.
NIH/PubMed — Keenan, 2013
✓ Pharmacotherapy review* — “No-flush/flush-free” niacin products generally do not deliver active free niacin for lipid effects.
NIH/PubMed — Backes, 2011
We monitor research from leading institutions —
Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge, Oxford, Stanford, Yale, Tufts, University of Florida, Oregon State University – Linus Pauling Institute, Columbia, Cornell, Ohio State — to align with credible science.*
Key Ingredients
- Niacin (Vitamin B-3) — 500 mg (from 640 mg of inositol hexanicotinate) per 2 capsules
- Inositol — 135 mg (from 640 mg of inositol hexanicotinate) per 2 capsules
- Other ingredients — Rice flour, hypromellose (cellulose capsule), microcrystalline cellulose, stearic acid (vegetable source), silicon dioxide
Brief Benefit Bullets
- Flush-minimized B3 option for those sensitive to niacin flushing*
- Human RCTs show IHN does not improve lipids vs placebo — use for B3 support, not lipid therapy*
- With clinical guidance, consider immediate-release/ER nicotinic acid if lipid modification is intended*
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3rd-party lab tested for identity, potency & purity*
Suggested Use
Adults: Take one (1) capsule once or twice daily with food, or as directed by your healthcare professional. If you require lipid management, speak with your clinician about the most evidence-based niacin form and dose. Do not exceed recommended dose. If pregnant, nursing, taking medications, or have a medical condition, consult your physician.*
Product Specifications
• Serving Size — 2 Veg Capsules
• Servings Per Container — 45
• Niacin (Vitamin B-3) — 500 mg (from 640 mg of inositol hexanicotinate)
• Inositol — 135 mg (from 640 mg of inositol hexanicotinate)
• Other ingredients — Rice flour, hypromellose (cellulose capsule), microcrystalline cellulose, stearic acid (vegetable source), silicon dioxide
• Not manufactured with wheat, gluten, soy, milk, egg, fish, shellfish, tree nut or sesame ingredients
• Produced in a GMP facility that processes other ingredients containing these allergens
• Quality — Third-party tested for identity, potency & purity
Perfect For
• Adults who want a niacin option with minimal flushing*
• Those seeking B3 intake support under clinician guidance*
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Niacin Flush Free (inositol hexanicotinate) — B3 support with minimal flushing; 90 caps. 3rd-party tested. Clinically Studied Ingredients — NIH/PubMed!*
