LifeSource Vitamins UC-II® 40 mg — 60 Capsules
Our UC-II Joint Support pairs clinically researched undenatured type II collagen with Aquamin® marine multimineral complex in vegetarian capsules to support joint comfort, promote flexibility and healthy mobility, support range of motion, promote knee function, help reduce activity-related joint discomfort, and support overall joint wellness* — while respecting traditional use. Produced in FDA-registered, GMP-certified facilities and 3rd-party lab tested for purity and potency by LifeSource Vitamins.
Research-Driven & Verified Product.
Explore the clinical research, ingredient science, and global evidence supporting this product below.
Research Promise: At LifeSource Vitamins, our commitment is rooted in research and results. Every benefit below is supported by human clinical studies indexed in the National Institutes of Health (NIH) via PubMed, with full texts available in the National Library of Medicine (NLM) PubMed Central (PMC) when available. We also reference reviews from 39 leading health organizations and insights from 20 top global universities to keep our guidance aligned with credible, evidence-based science.* Every claim is supported by peer-reviewed human RCTs or meta-analyses whenever available.
Clinically Studied Benefits
✓ Improved knee joint extension* — Daily UC-II (40 mg) improved knee extension in active adults with activity-related joint discomfort over 12 weeks.* NIH/PMC — Lugo JP, 2013
✓ Enhanced knee ROM & function* — UC-II improved flexion/extension range and functional measures over 24 weeks in active adults.* NIH/PMC — Bloch MH, 2022
✓ Reduced joint pain vs placebo* — Significant improvements in pain during walking/standing and at rest in controlled trials.* NIH/PMC — Gupta RC, 2016
✓ Osteoarthritis symptom relief* — UC-II outperformed glucosamine + chondroitin for total WOMAC in knee OA.* NIH/PubMed — Liu X, 2016
✓ Supports oral-tolerance mechanism* — UC-II promotes antigen-specific oral tolerance and T-regulatory pathways relevant to joint comfort.* NIH/PMC — D’Amelio P, 2020
✓ Promotes functional support with Aquamin* — Marine multimineral complex improved 6-min walk distance and function in knee OA over 12 weeks.* NIH/PubMed — Frestedt JL, 2008
✓ Supports NSAID-sparing effects with Aquamin* — Enabled partial NSAID withdrawal while maintaining function in pilot studies.* NIH/PubMed — Jensen GS, 2009
✓ Supports mineral bioavailability with Aquamin* — Marine-derived Ca/Mg complexes show favorable bioavailability.* NIH/PMC — Kaur P, 2018
✓ Promotes lengthened pain-free exertion time* — UC-II increased pain-free activity duration during exercise.* NIH/PMC — Lugo JP, 2013
✓ Supports balanced local joint immune responses* — UC-II promotes T-regulatory pathways relevant to joint comfort.* NIH/PMC — D’Amelio P, 2020
Additional / Promising Evidence
✓ Supports joint function in active adults* — UC-II improved knee flexion/extension and functional measures over 24 weeks.* NIH/PMC — Bloch MH, 2022
✓ Promotes marine multimineral skeletal co-support* — Aquamin provides bioavailable calcium, magnesium, and trace minerals for musculoskeletal health.* NIH/PMC — Kaur P, 2018
✓ Supports collagen's role in joint pain reduction* — Hydrolyzed collagen reduced activity-related discomfort in athletes.* NIH/PubMed — Clark KL, 2008
✓ Promotes UC-II superiority over glucosamine/chondroitin* — Improved total WOMAC scores in knee OA populations.* NIH/PubMed — Liu X, 2016
✓ Supports mineral bioavailability from marine sources* — Red-algae complexes show favorable absorption profiles.* NIH/PMC — Kaur P, 2018
✓ Promotes joint mobility and function in active adults* — UC-II enhanced range of motion and reduced discomfort.* NIH/PMC — Lugo JP, 2013
University-Led & Academic Studies
✓ Supports oral-tolerance mechanism for joint comfort* — UC-II promotes antigen-specific T-regulatory pathways in academic research.* NIH/PMC — D’Amelio P, 2020
✓ Promotes knee ROM & function in active adults* — University-affiliated trials show improvements over 24 weeks with UC-II.* NIH/PMC — Bloch MH, 2022
✓ Supports exercise-related joint pain reduction* — Academic studies confirm UC-II benefits for activity-related discomfort.* NIH/PMC — Lugo JP, 2013
Global Evidence & Reviews
✓ Supports UC-II across OA populations* — Clinical outcomes and safety summarized in NIH-indexed reviews.* NIH/PMC — Gupta RC, 2016
✓ Promotes updated UC-II clinical context* — Mechanisms and human evidence overview in recent reviews.* NIH/PubMed — Bansal S, 2023
✓ Supports collagen peptides in knee OA meta-analysis* — Symptom improvement vs placebo in syntheses.* NIH/PubMed — Lin CR, 2023
We monitor research from leading institutions —
Harvard, Johns Hopkins, Mayo Clinic, Cleveland Clinic, Cambridge, Oxford, Stanford, Yale, Tufts, University of Florida, Oregon State University – Linus Pauling Institute, Columbia, Cornell, Ohio State — to align with credible science.*
Key Ingredients
- UC-II® (Undenatured Type II Collagen, 40 mg) — Native collagen from chicken sternum cartilage that preserves its triple-helix structure, supporting antigen-specific oral tolerance pathways tied to joint comfort.*
- Aquamin® (250 mg; providing Calcium 80 mg, 6% DV) — Marine multimineral complex from red algae delivering bioavailable calcium, magnesium, and trace minerals for musculoskeletal co-support.*
Brief Benefit Bullets
- Supports joint comfort, flexibility & healthy range of motion*
- Clinically researched UC-II® 40 mg once daily*
- Aquamin® marine minerals for joint & bone co-support*
- Backed by human trials in active adults and OA populations*
- Non-GMO; produced in FDA-registered, GMP-certified facilities*
-
3rd-party lab tested for purity & potency*
Suggested Use
Adults: Take 1 capsule daily (preferably at bedtime and/or on an empty stomach), or as directed by a healthcare professional. Do not exceed suggested use. If pregnant, nursing, taking medications, or have a medical condition, consult your physician.*
Product Specifications
Serving Size — 1 capsule
Servings Per Container — 60
Actives (per capsule) — UC-II® Standardized Chicken Cartilage 40 mg; Aquamin® (whole plant) 250 mg providing Calcium 80 mg (6% DV)
Other Ingredients — Hypromellose (cellulose) capsule, microcrystalline cellulose, non-GMO corn starch, potassium chloride (stabilizer), stearic acid (vegetable source), silicon dioxide
Form — Vegetarian capsules; Non-GMO
Quality — Third-party tested for identity, potency & purity
Every LifeSource Vitamins product is 3rd-party lab tested for purity, potency, and label accuracy — because you deserve transparency and trust in every capsule.
LifeSource Vitamins — Proudly American — Since 1992
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
UC-II® 40 mg with Aquamin — 60 capsules — supports joint comfort, flexibility & mobility; once-daily, 3rd-party tested. Clinically Studied Ingredients — NIH/PubMed!*
