Vitamin E Helpful for Pediatric Liver Disease
Supplementing with vitamin E may improve liver function in obese children
with fatty liver disease who cannot adhere to a weight loss diet, reports a
study in the Journal of Pediatric Gastroenterology and Nutrition
(2004;38:48-55). Healthnotes Newswire (April 1, 2004)
Obesity is associated with the development of health conditions that affect
the cardiovascular, respiratory, hepatobiliary (referring to the liver and
gallbladder), metabolic, and musculoskeletal systems. Childhood obesity is
becoming increasingly prevalent, and may result in fatty accumulation in
the liver, followed by inflammation and death of liver cells. These changes
can be detected by liver enzyme elevations on a blood test and by
ultrasound of the liver, as well as by a liver biopsy. Fatty deposits in
the liver are seen as bright areas (called bright liver) on ultrasound.
One quarter of obese children who have bright liver on ultrasound
examination also have elevated levels of liver enzymes (an indication of
liver inflammation). Obesity-related fatty accumulation in the liver is a
form of nonalcoholic fatty liver disease. Nonalcoholic fatty liver disease
may range in severity from mild, with little or no permanent damage to the
liver, to severe liver damage that may lead to liver failure. The primary
goal in the treatment of obesity-related fatty liver disease is weight
reduction, as the early changes seen in the disease may be reversed with
The mechanisms for the progression of fatty liver disease are not known,
but some propose that free-radical damage to liver cells could be a cause.
The antioxidant vitamin E may protect against this. The current study
investigated the effect of vitamin E and a weight loss diet on liver enzyme
levels and bright liver in obese children with fatty liver disease.
Twenty-eight participants were randomly assigned to receive either (1) 400
IU of vitamin E per day for two months, followed by 100 IU of vitamin E per
day for three months, and a low-calorie diet, or (2) placebo and a
low-calorie diet. Both groups were given a moderate exercise program to
follow for the study period.
Those participants who received vitamin E but were unable to lose weight
experienced a statistically significant decrease in liver enzyme levels.
Vitamin E treatment did not appear to benefit to those people who were able
to lose weight. Participants in the placebo group who were able to lose
weight also had significant reductions in liver enzyme levels, compared
with placebo group participants who were not. The disappearance of bright
liver on ultrasound was only seen in those participants who lost weight,
regardless of whether or not they received vitamin E. Adherence to the
low-calorie diet was poor in both groups, so liver enzyme reductions among
those receiving vitamin E who did not lose weight was a significant
Other studies have found a similar benefit of antioxidant vitamins in the
treatment of nonalcoholic fatty liver disease. This is the first controlled
pediatric study to confirm vitamin E's role in reducing liver inflammation
in obesity-related fatty liver disease.
See Other LifeSource Vitamins Vitamin E Products, Articles, and
Proudly Made in the USA!
Every LifeSource Vitamins product exceeds all regulatory standards and
requirements set forth in the FDA's Code of Federal Regulation. (
21 CFR, part 111
as well as all Good Manufacturing Practices enforced by the FDA. CGMP's
provide for systems that assure proper design, monitoring, and control of
manufacturing processes and facilities. (
LifeSource Vitamins: Driven by Faith ~ Powered by God
Have Questions on this or any other product or health issue for you or a
loved one? It can be overwhelming we know. Call us, we will walk you
through what supplements will help you and which ones you really don’t
need. It’s what we do! Toll-Free: 800-567-8122
LifeSource Vitamins – Founded in 1992
100% of our profits are donated to Christian Organizations like these
and many others worldwide:
Campus Crusade for Christ - CRU
The Jesus Film Project
The Tim Tebow Foundation
The Herman and Sharron Show on CTN (Christian Television Network)
and many more…
E-mail Us: info@LifesourceVitamins.com
or Call Us: 800.567.8122
We Are Built on Compassion - Driven by Faith & Powered by God!
None of the above statements have been evaluated by the FDA. These products
are not intended to diagnose, treat, cure or prevent any disease.
As always, consult your physician before taking any and all
LifeSource Vitamins. Individual results may vary.
All the information contained throughout this website is based upon the
opinions of the founder of LifeSource Vitamins, Bruce Brightman, and the
entire team at LifeSource Vitamins whose relentless research and studies
have been ongoing since 1992. Other articles and information are based on
the opinions of the authors, who retain the copyright as marked in the
article. The information on this site is not intended to replace your
health care professional, but to enhance your relationship with them. Doing
your own studying and research and taking your health care into your own
hands is always best, especially in partnership with your health care
If you are pregnant, nursing, taking medications, or have any medical
conditions, always consult your health care professional before taking
supplements based on the information on this site.
LifeSource Vitamins: from the nutrients we choose, to the way we run
our business, we answer to God in all we do!