Resveratrol is a polyphenol naturally found in the skin of red grapes, certain berries, and other plants. Scientific studies have shown that Resveratrol supports healthy cardiovascular function through various mechanisms. Resveratrol, especially when combined with other polyphenols, is known for its anti-aging effects, as well as for its ability to support a healthy inflammatory response. LifeSource Vitamins Natural Resveratrol contains a comprehensive blend of polyphenols, including natural resveratrol and proanthocyanins (OPC's from grape seed), plus catechins (green tea extract) for powerful cardiovascular protection.*
What is Resveratrol?
of red grapes contain a component phytoalexin known as Resveratrol
and is an ingredient of red wine. Tests conducted that resveratrol medication
increased the life of fruit flies, nematode worms and fish with short life
span. Benefits observed in the case of rat and mouse experiments like
anti-inflammatory, blood-sugar reduction and anti-cancer and cardiovascular
effects with resveratrol treatment.
Resveratrol supplements are useful in preventing skin cancer, intestinal tumors and breast
cancer backed by medical studies. Resveratrol can also beneficial to
calorie restriction as this stimulates Sirtuin 1 (SIRTI 1) gene and PGC -1 and
induce functioning of mitochondria in our cells. Resveratrol can keep our body
young and longevity of our healthy life. This supplement can perform
biochemical effects of calorie
restriction. This supplement also showed positive results on colon, esophageal, prostate and pancreatic cancers
and leukemia. Consuming resveratrol can rejuvenate cells in the body and
acts as anti-oxidants thereby preventing aging of the human body. Helping to
keep your body forever young, energetic and healthy.*
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Puzzle of "French Paradox"
Natural Product Solved ( Natural Resveratrol )
September 21, 2004
La Jolla, CA — Researchers at the
Salk Institute have successfully bioengineered resveratrol synthase from
chalcone synthase, a biosynthetic protein enzyme found in all higher plants.
Their findings appear in the September issue of Chemistry & Biology.
Using the tools of structural biology, Michael B. Austin, a graduate student at
the Salk Institute and the University of California, San Diego, solved the
three-dimensional structure of resveratrol synthase and compared its shape to
its relative, chalcone synthase. Austin, part of a research team led by
Professor Joseph P. Noel of the Salk Institute has now uncovered the crucial
differences between these related plant enzymes.
Besides illuminating molecular mechanisms of plant evolution, this study also
has agricultural and nutraceutical significance. Noel and colleagues used their
new knowledge to convert a chalcone synthase from alfalfa into an efficient
resveratrol-producing factory, merely by changing a few amino acids (the
building blocks of proteins). This biotechnological advance permits the
engineering of natural resveratrol production into crop plants, via a small
modification of that plant's own chalcone synthase gene, as occurs naturally in
grapes, blueberries, and a few other plants.
Resveratrol, a beneficial component of red wine, is thought to partly
contribute to the improved cardiovascular effects associated with the moderate
consumption of red wine (the "French Paradox"). Laboratory studies
with resveratrol have demonstrated an impressive list of health benefits,
including roles as anti-oxidants, cancer preventative agents, blood thinners,
and blood pressure-lowering compounds. Recently, resveratrol was shown to
significantly increase life span in both fruit flies and yeast, suggesting an
additional role in human diets as a promising anti-aging natural chemical.
"We want to continue to explore taking what occurs naturally in plants and
work toward producing this rare molecule in other crop plants," said Noel.
"Ultimately, our research could lead to producing resveratrol in a wide
array of fruits and vegetables."
The impressive health benefits of resveratrol consumption are a lucky accident,
however, as grapes actually produce resveratrol in order to defend against
fungal invasion. Salk researchers have now deciphered the three-dimensional
structure of the rare plant enzyme that creates this remarkable but rare
molecule, and in the process they resolved a long-standing scientific puzzle:
the crucial differences between chalcone synthases and their
resveratrol-producing relatives, the much rarer stilbene synthases.
Scientists realized decades ago that chalcones and stilbenes, two important
classes of plant natural products with very different properties, were produced
by different but closely related proteins. All higher plants possess chalcone
synthase, as chalcone-derived natural chemicals fulfill a number of important
biological functions in plants including roles in plant fertility, disease
resistance, and flower color. Conversely, production of resveratrol and other
rare anti-fungal stilbenes occurs in just a few plant species, including
grapevines, peanuts, blueberries and some pine trees.
The Salk Institute for Biological Studies, located in La Jolla, Calif., is an independent nonprofit organization dedicated to fundamental discoveries in the
life sciences, the improvement of human health and conditions, and the training
of future generations of researchers. Jonas Salk, M.D., founded the institute
in 1960 with a gift of land from the City of San Diego and the financial
support of the March of Dimes Birth Defects Foundation.
- Decreased platelet stickiness (means decreased platelet
aggregation & clotting)
- Reduced LDL cholesterol oxidation
- Promotes phase II detoxification enzymes (increase
removal of toxins from the body)
- Inhibition of COX-2 enzyme induction (can result in
- Phytoestrogen (could reduce the risk of some cancers)
- Role in Alzheimer's disease prevention
LifeSource Vitamins - Resveratrol Plus - w/ Green Tea Extract and Grape Seed Extract. Resveratrol especially when combined with other polyphenols, is known for its anti-aging effects, as well as for its ability to support a healthy inflammatory response.*
Antioxidants are especially
important as we strive to prevent heart disease. Antioxidants slow and prevent
the oxidation of cells. For example, it is the oxidation of LDL cholesterol
that begins the formation of plaque within the artery walls. Oxidation causes stress
and cell damage that reduces a cells ability to function properly, eventually
leading to cell death. By consuming a diet high in antioxidants, such as
resveratrol, you promote decreased oxidation and cell health.*
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diagnose, treat, cure or prevent any disease. As always, consult your
physician before taking any and all supplements. LifeSource Vitamins.
Individual results may vary.
Disclaimer: All the
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LifeSource Vitamins whose relentless research and studies have been ongoing
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the authors, who retain the copyright as marked on the article. The
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