Protandim - Antioxidants
The unique blend of
phytonutrients in LifeVantage's Protandim signal your body's genes to produce
special antioxidant enzymes, SOD (superoxide dismutase) CAT (catalase) that
work together as the body's first line of defense against free radicals.*
These enzymes are
"catalytic", which means that SOD and CAT are not used up when they
neutralize free radicals.
A single daily caplet of
Protandim creates a cascade of your body's natural catalytic antioxidants that
are able to destroy millions of free radicals per second, on a continuous basis
- 24/7. FREE RADICAL KILLERS!
Protandim is a patented dietary
supplement that increases the body's natural antioxidant defenses. Protandim is
not an antioxidant per se, but provides antioxidant therapy by inducing the
genes that encode a family of protective enzymes, including superoxide
dismutase (SOD) and catalase (CAT). Protandim's mechanism of action is to
prevent free radical damage by increasing endogenous catalytic pathways,
whereas traditional antioxidant supplements provide only stoichiometric
scavenging of free radicals or other oxidants.*
The age related increase in
oxidative stress markers was completely eliminated. So while no one claims
Protandim is a cure for aging, it has been shown to greatly reduce or eliminate
certain biochemical processes associated with aging.*
The scientific evidence showing
Protandim works is based on clinical study results using a TBARS
(thiobarbituric acid reactive substances) measurement, which reflects the
damage to cell membranes from oxidative stress. This damage is caused by free
radicals that are produced by our own metabolic processes, and naturally
increases as we age.*
stress, generated through the process of living life (eating, sleeping,
breathing, exercising), is inevitable for everyone. But LifeVantage has the
solution: Protandim, the Nrf2 Synergizer®, the most important dietary
supplement of our time.*
Comprised of natural plant ingredients, Protandim is a patented, science-based
formula that has been researched, tested and validated by renowned universities
and institutions. It is the only supplement clinically proven to reduce
oxidative stress in humans by an average of 40 percent in 30 days.
Protandim activates Nrf2, which communicates with cells, instructing them to do
what they’re already designed to do: up-regulate “survival genes,” genes that
enable cells to survive in the face of stress from free radicals and other
oxidants, and down-regulate other genes to help the body function at an optimal
WHAT IS A FREE RADICAL & WHAT DOES IT DO?
For many years the existence of
free radicals in biological systems was dismissed as either non-existent or
simply an unimportant curiosity. However, more recently due to improved
investigational techniques, this view has changed rather dramatically.
Currently, free radicals have found a place in the aetiology of many diseases
and there is a great deal of enthusiasm regarding the role of free radicals in
many previously unexplained disease phenomena. To name a few important areas;
free radicals have found a role in the rheumatoid arthritis, Alzheimer's
disease, hypertension, myocardial ischemia, liver cell injury and
The reason as to why the role
of free radicals has been so ambiguous is probably due to their ultra-short
half-life. However, free radicals have finally come into existence through the
use of more sophisticated methods of assay.
The fact that they are highly
reactive means that they have low chemical specificity; i.e. they can react
with most molecules in its vicinity. This includes proteins, lipids,
carbohydrates and DNA. It also means that in trying to gain stability by
capturing the needed electron they don't survive in their original state for
very long and quickly react with their surroundings. Hence, free radicals
attack the nearest stable molecule, "stealing" its electron. When the
"attacked" molecule loses its electron, it becomes a free radical
itself, beginning a chain reaction. Once the process is started, it can
cascade, finally resulting in the disruption of a living cell.*
Antioxidants are molecules
which can safely interact with free radicals and terminate the chain reaction
before vital molecules are damaged. Although there are several enzyme systems
within the body that scavenge free radicals, the principle micronutrients
cannot be processed fast enough to keep up with these free radicals that are
occurring each second of the day. This happens more and more as we age, so in
effect, our bodies own aging causes the advancement of harmful free radicals
and then the free radicals cause us to age faster and over 200 diseases are
tied to free radicals so far.*
This is when Protandim comes into play.
The two most important
oxygen-centered free radicals are superoxide and hydroxyl radical. They are
derived from molecular oxygen under reducing conditions. However, because of
their reactivity, these same free radicals can participate in unwanted side
reactions resulting in cell damage. Many forms of cancer are thought to be the
result of reactions between free radicals and DNA, resulting in mutations that
can adversely affect the cell cycle and potentially lead to malignancy. Some of
the symptoms of aging such as atherosclerosis are also attributed to
free-radical induced oxidation of many of the chemicals making up the body. In
addition free radicals contribute to alcohol-induced liver damage, perhaps more
than alcohol itself. Radicals in cigarette smoke have been implicated in
inactivation of alpha 1-antitrypsin in the lung. This process promotes the
development of emphysema.*
Free radicals may also be
involved in Parkinson's disease, senile and drug-induced deafness,
schizophrenia, and Alzheimer's. The classic free-radical syndrome, the
iron-storage disease hemochromatosis, is typically associated with a
constellation of free-radical-related symptoms including movement disorder,
psychosis, skin pigmentary melanin abnormalities, deafness, arthritis, and
Scientists agree that aging and
many deadly diseases are the result of cellular deterioration due to rogue
molecules called free-radicals .
Free-radical damage is known as
Oxidative Stress or Oxidative Damage. Protandim fights the free radicals that
PROTANDIM is the only
supplement clinically proven to reduce oxidative stress by an average 40%,
slowing down the cell aging process to the level of a 20 year-old.* Protandim
is not a conventional antioxidant supplement. Each Protandim caplet contains a
unique combination of phytonutrients that signal the body's genes to produce
its own antioxidant enzymes, which provides thousands of times more antioxidant
power than any food or conventional antioxidant supplement.
Your Body's Ability to Battle Aging Decreases
As You Age
The aging process is nature's
way of limiting the population of every species. It's good for the species, but
not so good for the individual. When you're young, your body fights
free-radicals effectively by producing its own antioxidants. But as you grow older,
your body produces less antioxidants to fight the battles of aging and disease.
Antioxidant Rich Foods & Supplements
Can't Keep Up With Free-Radicals.
Protandim provides you with
thousands of times more antioxidant power than any food or conventional
supplement.* In fact, you would need to consume the antioxidants found in 375
oranges or 87 glasses of red wine or about 120 vitamin C tablets (500mg) a day
to neutralize the amount of free radicals your body produces every single day.*
Not all antioxidants are equal.
Conventional antioxidant supplements (such as vitamins A, C and E) are known as
"consumable" antioxidants because they are used up as they neutralize
free radicals on a one-to-one basis. The unique blend of phytonutrients in Protandim
signal your body's genes to produce special antioxidant enzymes (SOD and CAT)
that work together as the body's first line of defense against free radicals.*
These enzymes are "catalytic" , which means that SOD and CAT are not
used up when they neutralize free radicals.
A single daily caplet of
Protandim creates a cascade of your body's natural catalytic antioxidants that
are able to destroy millions of free radicals per second, on a continuous basis
All Natural Ingredients
The natural ingredients in
Protandim were specifically chosen based upon their ability to cause the body
to produce and up-regulate its natural network of antioxidant enzymes,
including SOD and CAT. Protandim has been formulated using high quality, potent
herbal extracts processed under proprietary technologies. It therefore provides
powerful antioxidant protection against oxidative stress.
The following is a
list of Protandim ingredients:
Proprietary Blend 675
Milk thistle extract (Silybum marianum) (seed) Bacopa extract (Bacopa
monnieri) (aerial part) Ashwagandha (Withania somnifera) (root) Green tea
extract (Camellia sinensis) (leaf) Turmeric extract (Curcuma longa) (rhizome)
Additional ingredients: Calcium, Croscarmellose sodium, magnesium
stearate, microcrystalline cellulose, modified cellulose, silica, stearic acid.
Protandim is 100% Vegetarian
Free of Gluten, Wheat, Dairy, Gelatin and Yeast.
Protandim has been shown in a published, peer
reviewed human study to eliminate the age-related increase in cell aging
Protandim is not an antioxidant
supplement. It helps your body produce its own antioxidants with thousands of
times more antioxidant power than any food or conventional supplement.* and the
proof is conclusive.
Aging factors can be measured
accurately by the amount of TBARS (thiobarbituric acid-reactive substances)
found in the blood. In clinical trials with men and women, young and old, the
blood samples consistently demonstrated that after 30 days, taking one caplet a
day, test subjects realized a 40 percent average decrease in TBARS - the
progressive aging rate of a 20 year old! After 120 days to that of a new born
When maintained for 120 days,
Protandim significantly increased activity of SOD and CAT antioxidant enzymes
by 54 percent, substantially increasing the body's antioxidant defenses.* This
is equivalent to that of a new born child.
Protandim Evidence Mounts:
Doctors finally receive
clinical proof on a antitoxin supplement that slows down the progressive rate
of aging. This new supplement " Protandim" reduces Oxidative Stress
by an average of 40 %. Oxidative Stress has been linked to over 200 diseases,
such as Cancer, Diabetes, Alzheimer's . Blood Tests have shown that people at
any age bring their cellular health to that of a 20 year old after just 30 days
This begins a news release that
was issued not long ago leading into yet another story on the growing clinical
data supporting the effectiveness of Protandim.
There are presently studies
being conducted in over 20 major universities on the impact of Protandim with
Oxidative Stress, one of today's hottest medical topics. Dr. Joe McCord is the
scientist at the head of much of the data being compiled.
Protandim works differently
than other antioxidant supplements. It actually signals the cells in our bodies
to produce more of its own antioxidant enzymes, which provide thousands of
times more antioxidant power than any food or conventional supplement.
An investigation into Protandim
with boys with Duchenne Muscular Dystrophy (DMD) is particularly exciting,
according to Dr. McCord. Parents of a number of boys with DMD tried Protandim
with their sons and reported significant improvements in strength and endurance
as well as cognitive function. DMD is one of over 100 human diseases associated
with oxidative stress. DMD, by the way, is a genetic disease and impacts only
I share this with you because
there is a growing body of evidence about Protandim and the incredible impact
that it is having on so many aspects of our health issues. The earning
potential for Protandim sales is quite significant given the data now being
published. More studies are underway and when they are released, we will share
that data with you.
Oxidative stress, simply put,
is the damage made to a cell through the oxidative process.
Oxidation, in itself, is a very
normal process - it happens all the time to our bodies and many things that
However, when there are
disturbances in the natural oxidation process, such as the attraction of a free
radical to another molecule in your body, the results are often toxic effects.
Imagine an iron pipe lying on
the ground. As it weathers years of rain, environmental exposure, sun, and
other factors, it begins to rust.
The rust is caused by
oxidation. Free oxygen radicals are created during the metabolism of normal
oxygen cells, or oxidation. These free radicals are missing a simple electron
and are in search of another molecule that they can combine with to become "whole."
In their quest, they fire charges that damage other cells and structures around
them. This, in turn, causes the rust.
In effect, your body is
"rusting" as it goes through its lifetime, the free oxygen radicals
wildly running through your system, searching for a mate.
As you can see, the more free
radicals your body contains, the more damage that's likely to be done. The best
way to see this damage is through our normal aging process.
* Cancer results as the chain
damages cell membranes and DNA.
Oxidative Stress and Aging
While modern medicine has found
ways for humans to live longer, our quality of life - especially during the
last 30 years - has gone down.
Much of this can be attributed
to oxidative stress and the toxins that we're encountering more and more
throughout our lives.
A simple way to visually
experience the effects of oxidative stress on aging is to visit a nursing home.
Compare the skin of a five-year-old to that of a resident, and notice the
breakdown, wrinkles, and color as compared to the smooth, supple skin of a
Throughout our lives, our skin
encounters free radicals in many different forms, and their effect is clearly
obvious on our skin.
But oxidative stress isn't only
apparent on the outside. It's the cause of many or most diseases our society is
concerned with today.
Oxidative Stress and Disease
To date, science has discovered
that oxidative stress may very well be the cause of over 70 well-known,
Depending on what form of toxin
or stress your body is exposed to on an ongoing basis, you could find yourself
suffering, even at an early age, from diseases that could be prevented if only
you'd have minimized the harmful free radicals in your system.
A Look at Free Radicals
Obviously, even back in the early
days of man, free radicals existed and caused oxidative stress. They're
inherent to life and a normal byproduct of regular oxygen molecule metabolism.
However, our bodies were only made to withstand so much exposure to free
radicals (even though our body does an amazing job at neutralizing them in a
normal, low-toxin setting).
The increased and prolonged
exposure to these wild and reckless free radicals cause a faster build-up of
"rust" or disease in our bodies.
So what are some of the most
common reasons our bodies' oxygen molecules oxidize themselves into an
increased amount of free radicals? Some of them you're probably well aware of,
and some of them may come as a surprise.
Environmental & Air Pollution, Cigarette
Smoking Excess, Stress Prescription & Over the Counter Medications. Radiation Increased Exposure to Sunlight and Excessive
THE REAL STORY ON FREE RADICALS.
Very few individuals, if any,
reach their potential maximum life span; they die instead prematurely of a wide
variety of diseases--the vast majority being "free radical" diseases.
--Denham Harmon, M.D., Ph.D., who in 1954
first proposed the Free Radical Theory of aging
Honey, take a look at this. You might find it
Great moments in human history
often begin inauspiciously. Such was the case in December 1945, when the wife
of Denham Harmon handed him the latest issue of the Ladies' Home Journal. It
was opened to an article titled "Tomorrow You May Be Younger,"
written by William L. Laurence, science editor of the New York Times. This
article, heralding the work of a Russian gerontologist on an
"anti-reticular cytotoxic serum," sparked Dr. Harmon's interest in
finding an answer to the riddle of aging--a subject that scientists of the time
knew absolutely nothing about. Even to this day most MD's know very little
about Free Radicals/Oxidative Stress.
For the next nine years, Dr.
Harmon, a brilliant young organic chemist with a Ph.D. from the University of
California, Berkeley, ruminated about the aging process.
Because aging is such a
universal phenomenon, he reasoned that it might have a single basic cause. But
what could it be? The answer eluded him.
Though still obsessed with the
question, he had to place it on the back burner while he completed medical
school and an internship at Stanford University. Then one morning in November
1954, during a period in which he was simultaneously completing his residency
in internal medicine and doing research at Berkeley's Donner Laboratory, Dr.
Harmon's quest ended. That day, while reading in his office, he had an
"aha" experience that would revolutionize medical science: "(It)
suddenly occurred to me that free radical reactions, however initiated, could
be responsible for the progressive deterioration of biological systems."
of course, sometimes even the best ideas are slow to be accepted. This one
didn't exactly inspire words of praise--not at first, anyway. After thinking it
over for a month, Dr. Harmon strolled the Berkeley campus, knocking on doors
and presenting his newly formulated Free Radical Theory to his colleagues. To
say that it was a hard sell would be an understatement. He might have had more success
had he been hawking vacuum cleaners.
The scientists whom Dr. Harmon
approached were singularly unimpressed. In fact, all but two flatly rejected
his idea. One after another, they slammed the door in the face of the young
upstart, who dared challenge the status quo with the preposterous notion that
all degenerative disease--and the aging process itself--could be explained by
the presence of free radicals.
Undaunted, Dr. Harmon pursued
his theory. In subsequent years, he demonstrated how the effects of free
radicals are reversed by nutrients known as antioxidants, how antioxidants
extend the life spans of laboratory animals, and how antioxidants offer
protection against heart disease, cancer, senile brain disease, and all other
degenerative conditions associated with aging. Dr. Harmon proved that
age-related immune deficiency is caused by free radicals and can be reversed by
In terms of scientific
significance, Dr. Harmon's Free Radical Theory ranks with Galileo's invention
of the telescope, Newton's discovery of gravity, and Einstein's theory of
relativity. No breakthrough has had more profound implications for human health
Now in his mid-eighties and
still professionally active, Dr. Harmon deserves the Nobel Prize for his
Free Radicals: Longevity's Most Formidable
Dr. Harmon's Free Radical
Theory has emerged as the best understood and most widely accepted explanation
of the aging process. Having stood the test of time and countless research
validations, it has become not just a damage theory but the damage theory. (You'll
recall from chapter 1 that according to damage theories, cumulative cellular
damage determines a person's age of death.) In fact, among doctors specializing
in anti-aging medicine, Free Radical Theory has transcended mere theory status
and is considered a biological fact of life.
Just what are these free
radicals, anyway? Understanding where they come from, and why and how they do
so much damage, requires a brief lesson in biochemistry.
Molecules are made up of atoms
glued together by chemical bonds. Each bond consists of a pair of electrons.
When a bond is broken, what's left are two molecular fragments, each of which
contains one of the now unpaired electrons. These molecular fragments are
highly charged and highly unstable, because they contain only one electron
rather than two. These highly charged, highly unstable, highly reactive
particles are what we know as free radicals.
Unfortunately for us humans,
the biochemical saga of free radicals doesn't end there. Remember, each free
radical contains one unpaired electron. And unpaired electrons, like unpaired
humans, hate to be alone. They want a partner, and they're not above breaking
up another bond to get what they want. Scientists call this process oxidation,
and free radicals are masters at it. They're not particularly discriminating
about where they get their new partners, either. They'll oxidize just about
anything that gets in their way--punching holes in cell membranes, destroying
key enzymes, and fracturing DNA.
What's more, free radicals are
remarkably prolific. One free radical, unchecked, can cause new ones to form.
These free radicals, in turn, give rise to many more. How does this happen?
Because it has so much energy,
a free radical zips about until it bangs into a nearby molecule with a stable
bond. The collision splits the stable molecule, releasing one of its two
electrons. The free radical nabs the electron as a partner for its own unpaired
electron, and the two form a stable bond. All this happens, quite literally,
The good news is that the free
radical has stabilized itself. The bad news is that in doing so, it may have
caused the formation of two more free radicals by breaking a stable bond,
leaving the two atoms of the formerly stable molecule to share one unpaired
electron. So begins a chain reaction that produces thousands of molecular
fragments with unpaired electrons. And every one of these fragments is
careening about, looking to swipe an electron from an unsuspecting stable
To get a clearer understanding
of how free radicals multiply, imagine a football stadium filled to the brim
with mousetraps, each mousetrap loaded with a Ping-Pong ball. If you drop one
Ping-Pong ball into the stadium, it springs one mousetrap, causing it to fling
its ball into the air. Then you have two loose Ping-Pong balls, which spring
two more mousetraps. Within a matter of seconds, all of the mousetraps are
sprung, and all of the balls are loose.
Now if all those mousetraps
were stable molecules, and all those Ping-Pong balls were free radicals, you
would have just witnessed a free radical free-for-all.
In their reckless quest for
electrons, free radicals do a lot of structural damage to healthy cells.
Injured cells can't function properly and may even die.
Most vulnerable to free radical
attack is the cell membrane, which surrounds each cell and guards its jellylike
interior. The cell membrane is a sophisticated, highly selective barrier whose
all-important job is to guard access to the cell. It decides what gets in, what
stays in, and what is expelled (forcibly, if need be). If cells were
nightclubs, then cell membranes would be bouncers.
Inside each cell are many
subcellular structures called organelles. Each organelle is wrapped in its own
protective outer membrane and performs a highly specialized function.
Mitochondria, for example, transform oxygen and food into energy, which the
cell uses to carry out its tasks. Lysosomes scarf up and digest cellular
garbage, which is then either recycled or jettisoned. The cell's nucleus is
also an organelle. It houses DNA, the cell's genetic blueprint.
When a cell membrane or an
organelle membrane is damaged by free radicals, it loses its protective
properties. This puts the health of the entire cell at risk.
The cell membrane is a pushover
for free radical attack because it is composed primarily of easily oxidized
fatty acids. Like tiny but powerful bullets, highly charged free radical
particles rip into the cell membrane, literally puncturing holes in it. A
damaged cell membrane loses its selectivity. When this happens, transportation
of nutrients, oxygen, and water into the cell and removal of waste products
from the cell become compromised.
In much the same way, free
radical damage to an organelle's membrane sabotages the organelle's function.
When mitochondria are injured, for instance, these submicroscopic power plants
can't produce the energy necessary to drive the cell's machinery. If damage to
the mitochondrial membrane is extensive, the cell dies.
Free radicals can even bang
their way through the protective membrane surrounding the nucleus, gaining
access to the DNA molecules housed inside. If free radicals happen to break the
DNA molecules in order to snatch electrons, the cell dies, or loses its ability
to replicate, or replicates abnormally--a process known as mutation. Mutation
can give rise to the collections of abnormal cells that we know as cancer.
But cancer isn't the only health
problem for which free radicals are responsible. Cumulative free radical damage
contributes to all sorts of organ- and tissue-specific diseases, including
allergies, Alzheimer's disease, arthritis, atherosclerosis (hardening and
clogging of the arteries), cancer, cataracts, infections, macular degeneration,
multiple sclerosis, and Parkinson's disease. In fact, researchers now agree
that most common ailments, including virtually all chronic degenerative
diseases, are either caused directly by or are closely associated with free
Immune Cells: Dedicated Defenders
Of all the cells in your body,
immune cells are the most likely victims of free radical attack. Ironically,
they put themselves at risk just by carrying out their assigned task.
Immune cells scavenge free
radicals. If injured, immune cells are less able to do their job. In the short
run, their impairment usually doesn't produce symptoms. Over time, persistent
fatigue, recurrent infections, and allergies may be among the first signs of
If free radicals continue their
attack on immune cells, and if the cells never get a chance to heal, the
accumulated damage weakens the immune system even more. Eventually, this opens
a potential Pandora's box of disorders caused by altered immune function. Free
radical damage to an immune cell's protective outer membrane or DNA can be
Once damaged, an immune cell
loses its ability to differentiate between good guys and bad guys. One of two
scenarios, neither good, then unfolds. In the first, immune cells mistake
friends for foes and begin attacking healthy tissues. This is known as an
autoimmune disease, examples of which include lupus, multiple sclerosis, and
rheumatoid arthritis. In the second scenario, immune cells mistake foes for
friends. For example, they may fail to recognize cancer cells and, rather than
annihilating them, ignore them and allow them to multiply.
The Link to Aging
Prolonged exposure to free
radicals actually fast-forwards the aging process. One of the clearest
manifestations of cumulative free radical damage is a phenomenon known as
Cross-linking affects protein,
enzyme, DNA, and RNA molecules. A bit like handcuffing, it hampers the ability
of its molecular hostages to perform their assigned tasks. In this way,
cross-linking works to the detriment of the entire organism--especially if that
organism happens to be your body. Because of cross-linking, the elastic,
flexible tissue of youth gives way to the wrinkled skin, stiff joints, and
hardened arteries of old age.
What's more, cross-linking
worsens with age, as the cellular wear and tear of several decades accumulates
and the body becomes less adept at scavenging free radicals. The result is the
general, body-wide impairment of function that's synonymous with degenerative
disease and aging.
In skin cells, the
cross-linking of molecules causes the wrinkles characteristic of aging. In
arterial cells, cross-linking reduces flexibility, which in turn raises blood
pressure and puts extra strain on the heart as it pumps harder to maintain a
continuous flow of blood. In the brain, cross-linking impedes message
transmission between nerve cells--not good if you prefer crisp thinking and a
rapid flow of ideas. Thought processes slow down, and memory and concentration
problems are more likely.
For all of cross-linking's
dirty work, its effects on DNA molecules may be most problematic. When these
molecules are damaged, they compromise the cell's ability to correctly
interpret its DNA-encoded genetic blueprint. This results in impaired DNA
replication and protein assembly. The entire process of Renewal depends on
cells being able to replicate themselves exactly. This is why the failure to
protect a cell's genetic coding has particularly profound consequences.
Meet the Free Radical Formers
Since free radical damage
fosters disease and shortens life, it stands to reason that we need to know not
only where these rogues come from but also how to avoid them--or at least limit
Unfortunately, free radicals
are everywhere. They're in the foods we eat, the water we drink, the air we
breathe. Even our bodies produce free radicals.
Our bodies are equipped to rein
in and dispose of free radicals. The problem is that we usually have more of
these troublemakers floating around than our bodies can manage. And that's when
we run into problems.
Any combination of factors that
produces excessive free radicals (or suboptimal scavenging) can ultimately
cause mass destruction throughout the human body. This destruction has been
linked to the development of disease and the acceleration of aging.
True, some sources of free
radicals we can't control. But many we can. Here's a rundown of the primary
The Most Surprising Source
As you read this sentence, your
body is generating humongous quantities of free radicals. And believe it or
not, it's quite normal.
You see, these free radicals
are a kind of cellular "exhaust"--a by-product of metabolism. They're
produced as cells use oxygen to convert food into energy. The only way to avoid
these free radicals would be to stop burning oxygen. But then your metabolism
would shut down, too.
Because these free radicals are
really your body's own doing, your body expects them and is designed to deal
with them. It has highly efficient ways of grabbing and neutralizing these
renegade particles before they can do harm. So your cells just keep on making
The Usual Suspects
The free radicals that occur
naturally within your body should be no cause for concern. It's the excess free
radicals, the ones that your body is not prepared to handle, that cause
life-shortening damage. This extra load results from two key factors: an
overabundance of toxins and a shortage of antioxidants (more on these later).
A complete list of all the
external sources of free radicals would likely run on for pages. So here are a
few of the more pernicious offenders.
The standard American diet. The
standard American diet is a free radical fiasco just waiting to happen. It's
liberally laced with high-fat, processed, preserved, pesticide-laden,
chemically treated foods. It's chock-full of known free radical formers such as
meat, butter, margarine, sugar, white flour, and alcohol. It emphasizes frying,
browning, and other cooking methods that exponentially drive up the free
radical count. Most significant of all, it's dangerously deficient in
antioxidant-rich, free radical fighting fruits and vegetables.
A high-fat diet. Consuming more
than 10 percent of your calories from fat dramatically increases your body's
free radical load. The reason: When bombarded by free radicals, fat molecules
split apart easily. The weak bonds that hold together polyunsaturated fat
molecules are especially sensitive to and readily broken by heat, light, or
oxygen. The more fat you ingest, the more free radicals your body generates.
This is why heart disease and cancer, two conditions associated with cumulative
free radical damage, are most common in people who consume high-fat diets.
Trans-fats. Also known as
funny-fats or ugly fats (because of what they do to the body), trans-fats are
seething cauldrons of free radical activity. They're created by cooking at high
heat and by hydrogenation (the process used to harden liquid vegetable oils).
Most people get their trans-fats from the margarine they spread on their
morning toast, the shortening in most baked goods, and the hydrogenated oil in
processed and convenience foods (such as crackers, chips, and nuts). The
average American ingests 100 pounds of trans-fats annually, a tremendous free
Chemicals. Some of the nastiest
and most pervasive free radicals come from the vast and expanding array of
toxic chemicals being released into the environment. Chlorination of water
supplies spawns often dangerous levels of chloroform and trihalomethanes, both
powerful free radical formers. The air is also saturated with free radical
formers: oxides of sulfur and nitrogen, ozone (which is beneficial to humans
only if it stays in the upper atmosphere), chlorine, aromatic hydrocarbons
(such as benzene and toluene), formaldehyde, carbon monoxide, lead, asbestos,
and tobacco smoke. The combustion of tobacco alone creates thousands of
different free radical generating chemicals. Even if you don't smoke, you may
have a hard time escaping from secondhand smoke.
Pesticides. Pesticides are
notorious free radical formers. They're also very soluble in fat. This means
they're found in much larger quantities in foods of animal origin, which are
naturally high in fat, than in foods of plant origin. Why? Well, an animal eats
pesticide-sprayed feed every day over the course of its lifetime. The pesticide
residues become concentrated in the animal's fatty tissues, the result of a
vain attempt by the animal's body to remove the toxic substances. Then when you
eat food from that animal--be it steak, chicken, milk, cheese, or butter--your
body likewise tries to rid itself of the toxins by storing them in fatty
tissues. Hidden away, the pesticide molecules eventually initiate free radical
chain reactions. This phenomenon helps explain the epidemic of heart disease
and cancer among meat-eaters.
radiation--including medical and dental x-rays, radon gas, and ultraviolet
radiation from the sun--fractures stable molecules. In doing so, it creates
free radicals. Cells are extremely sensitive to radiation, with the cell
membranes and the chromosomes in the nuclei at highest risk for damage. And
radiation doesn't have to be strong to do harm: Exposure so weak that it
destroys only one molecule in 100 million can nevertheless trigger free radical
chain reactions capable of killing an entire cell. And if radiation scores a
direct hit on a cell's nucleus, the cell's DNA--the blueprint for cell
Victoria Johnson Center for
Lung Research, Virginia Commonwealth University, Richmond, VA 23298, USA.
Pathobiological mechanisms that
contribute to pulmonary vasoconstriction, lung vascular remodeling, and the
development of right heart failure include the generation of reactive oxygen
and nitrogen species and the response of lung vascular and cardiac cells to
these molecules. We review the information regarding oxidant stress balanced by
antioxidant mechanisms and the role of oxidants and antioxidants in hypoxic
pulmonary hypertension and their potential role in an animal model of severe
pulmonary arterial hypertension (PAH).
In human lung tissue from
patients with idiopathic PAH, we find reduced superoxide dismutase activity and
high expression of the oxidant stress markers nitrotyrosine and 8-OH-guanosine.
In the Sugen 5416/chronic hypoxia model of PAH, lung tissue expression of
nitrotyrosine and hemeoxygenase 1 (HO-1) is substantial, while HO-1 expression
in the failing right ventricle is decreased. This model, based on
administration of the VEGF receptor blocker Sugen 5416 and chronic hypoxia
(Su/Hx), reproduces many of the characteristic features of severe angioobliterative
human PAH. Treatment of Su/Hx rats with protandim, which nuclear factor
erythroid-2 related factor (Nrf2)-dependently upregulates the expression of
genes encoding antioxidant enzymes, protects against right heart failure
without affecting angioobliterative PAH.
In human severe PAH, patient
survival is determined by the function of the stressed right ventricle;
investigation of oxidative and nitrosative stresses and their potential
contribution to right heart failure is necessary.
strategies may be of benefit in the setting of human severe PAH. Whether
antioxidant strategies affect lung vascular remodeling and/or prevent right
heart failure remains to be examined.
Sources of Free Radicals
Avoiding free radical formers
may seem like an easy enough task. But the reality is, they're just about
everywhere. The following list provides a mere sampling of substances and other
factors that can cause a free radical overload. How many of these do you
encounter every day?
Foods of animal origin
Foods that have been barbecued,
broiled, fried, grilled, or otherwise cooked at high temperatures
Foods that have been browned or
Hydrogenated vegetable oils
Air pollutants such as
asbestos, benzene, carbon monoxide, chlorine, formaldehyde, ozone, tobacco
smoke, and toluene
Chemical solvents such as
cleaning products, glue, paints, and paint thinners
Over-the-counter and prescribed
Water pollutants such as
chloroform and other trihalomethanes caused by chlorination
Medical and dental x-rays
Join the LifeSource Vitamins
Send us your story or product
review. At LifeSource we strive for excellence in everything we do. Let us know
what is working for you and your family, we also love suggestions for future
products. Thank you for your continued support and may God bless you and your
Dear Mr. Brightman,
I've been taking Protandim
about four months. Since I began, I've noticed many things. The very first
thing I noticed was stronger muscles that were a lot less sore the day after
exercising. I haven't lost any weight but I've firmed up quite a bit. My skin
is firmer and holds more moisture now therefore, I have seen some fine lines
disappear on my face.
In addition, the stressful days
at the office don't wear me down like before. Also, I have increased energy,
better sleep, more hair, more balanced hormones, and definitely an increased
sense of well being. I am very excited about Protandim and look forward to
seeing more positive changes in my body.
Thanks for introducing me to
Protandim and offering me fantastic business
My husband and I have been
taking Protandim now since October 23rd, 2009. After only 2 weeks he asked me
if I noted any changes in myself. Until he asked I wasn't really aware, but I
noticed my prescription glasses were blurry and I could see better when I took
them off. My vision was so clear it was sometimes very stark to look about. My
husband noticed he no longer had difficulty driving at night, and we drove
straight through the night to Iowa, that was amazing. Then we both noticed the
snoring had completely gone away. The last thing I noticed and we have been
taking Protandim now for approximately 2 months, was all the age spots I had on
both my forearms have completely faded or disappeared.
We are now watching and waiting
for more changes as we continue on this program. We have so many friends that
have lost jobs just this past year and are without insurance. Protandim is the
answer to all of this.
Craig & Linda
I began using the product
personally on November 6. I have been tracking my blood pressure, body
temperature, weight, and urine ph daily (missing a few day here and there.) I
wanted to have some first hand results to share with others. After about 6
weeks, my blood pressure has gone down from an average of over 175/100 to about
143/86. My ph was in the 5.5-5.9 the first few days but has increased to the
6.3-6.8 range with several days logging in at over 7.0. My weight has decreased
from about 230 to 224 with no other dietary changes. We have also been giving
Protandim to my 95 year old father-in-law who lives with us and believe we are
seeing improvement in his mental clarity and awareness. My wife and our
grandson are also taking the product and I can only say that we all seem to
notice an overall improvement in our sense of well-being. I remain excited
about the health benefits of Protandim and look forward to the same excitement
of the business side.
I look forward to hearing from
I would like to take this time
to thank the LifeSource team for being such an inspiration to us. My son,
Eddie, started ordering from LifeSource a few years ago and became a
distributor as well. When Eddie shared his catalog with me at that time, I was
so impressed with all that was offered. I was originally reluctant to order
anything until I saw the difference the products he was using made thus
prompting me to begin ordering. The rest is history! Eddie and I both are so
encouraged that LifeSource is powered by God as it certainly shows when talking
with the staff at LifeSource specifically the founder and Laura (and I hope I
have her name correct!). May God continue to bless you richly in all you do!
Blessings and In Him!
I congratulate all of you who
have taken the time to read the immense scientific research on Protandim
written above - a product that I believe has the potential to truly change
My goal at LifeSource has
always been to help people live a longer, healthier life and to be diligent to
God. I have always believed God is guiding me on my path in life and He is
lighting the way of my future ("Thy Word is a lamp unto my feet, and a
light unto my path. Psalm 119:105").
May God bless you and your
loved ones always!
Bruce Brightman, Founder
E-mail Us: info@LifesourceVitamins.com
or Call Us: 800.567.8122
We Are Built on Compassion - Driven
by Faith & Powered by God!
It can be overwhelming we know.
Call us, we will walk you through what supplements will help you and
which ones you really don’t need. It’s what we do!
*Disclaimer: None of the above statements have been evaluated by the FDA. These
products are not intended to diagnose, treat, cure or prevent any disease. As
always, consult your physician before taking any and all supplements.
LifeSource Vitamins. Individual results may vary.
Disclaimer: All the information contained throughout this website is based upon the
opinion of the founder of LifeSource Vitamins, Bruce Brightman, and the entire
team at LifeSource Vitamins whose relentless research and studies have been
ongoing on since 1992. Other articles
and information are based on the opinions of the authors, who retains the
copyright as marked on the article. The
information on this site is not intended to replace your health care
professional, but to enhance your relationship with them. Doing your own studying and research and
taking your health care into your own hands is always best, especially in
partnership with your health care professional.
If you are pregnant, nursing, taking medications, or have any medical
conditions, always consult your health care professional before taking
supplements based on the information on this site.