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Protandim 30 Caps
Protandim 30 Caps

30 Caps

Comprised of natural plant ingredients, Protandim is a patented, science-based formula that has been researched, tested and validated by renowned universities and institutions. It is the only supplement clinically proven to reduce oxidative stress in humans by an average of 40 percent in 30 days. Kills Free radicals!

Protandim activates Nrf2, which communicates with cells, instructing them to do what they’re already designed to do: up-regulate “survival genes,” genes that enable cells to survive in the face of stress from free radicals and other oxidants, and down-regulate other genes to help the body function at an optimal level.

Read Below: Full Description, Clinical Studies & Research on Protandim.

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Protandim - Antioxidants

30 Caps
LifeSource Vitamins

The unique blend of phytonutrients in LifeVantage's Protandim signal your body's genes to produce special antioxidant enzymes, SOD (superoxide dismutase) CAT (catalase) that work together as the body's first line of defense against free radicals.*

These enzymes are "catalytic", which means that SOD and CAT are not used up when they neutralize free radicals.

A single daily caplet of Protandim creates a cascade of your body's natural catalytic antioxidants that are able to destroy millions of free radicals per second, on a continuous basis - 24/7. FREE RADICAL KILLERS!

Protandim is a patented dietary supplement that increases the body's natural antioxidant defenses. Protandim is not an antioxidant per se, but provides antioxidant therapy by inducing the genes that encode a family of protective enzymes, including superoxide dismutase (SOD) and catalase (CAT). Protandim's mechanism of action is to prevent free radical damage by increasing endogenous catalytic pathways, whereas traditional antioxidant supplements provide only stoichiometric scavenging of free radicals or other oxidants.*

The age related increase in oxidative stress markers was completely eliminated. So while no one claims Protandim is a cure for aging, it has been shown to greatly reduce or eliminate certain biochemical processes associated with aging.*

The scientific evidence showing Protandim works is based on clinical study results using a TBARS (thiobarbituric acid reactive substances) measurement, which reflects the damage to cell membranes from oxidative stress. This damage is caused by free radicals that are produced by our own metabolic processes, and naturally increases as we age.*

Oxidative stress, generated through the process of living life (eating, sleeping, breathing, exercising), is inevitable for everyone. But LifeVantage has the solution: Protandim, the Nrf2 Synergizer®, the most important dietary supplement of our time.*

Comprised of natural plant ingredients, Protandim is a patented, science-based formula that has been researched, tested and validated by renowned universities and institutions. It is the only supplement clinically proven to reduce oxidative stress in humans by an average of 40 percent in 30 days.

Protandim activates Nrf2, which communicates with cells, instructing them to do what they’re already designed to do: up-regulate “survival genes,” genes that enable cells to survive in the face of stress from free radicals and other oxidants, and down-regulate other genes to help the body function at an optimal level.


For many years the existence of free radicals in biological systems was dismissed as either non-existent or simply an unimportant curiosity. However, more recently due to improved investigational techniques, this view has changed rather dramatically. Currently, free radicals have found a place in the aetiology of many diseases and there is a great deal of enthusiasm regarding the role of free radicals in many previously unexplained disease phenomena. To name a few important areas; free radicals have found a role in the rheumatoid arthritis, Alzheimer's disease, hypertension, myocardial ischemia, liver cell injury and carcinogenesis.*

The reason as to why the role of free radicals has been so ambiguous is probably due to their ultra-short half-life. However, free radicals have finally come into existence through the use of more sophisticated methods of assay.

The fact that they are highly reactive means that they have low chemical specificity; i.e. they can react with most molecules in its vicinity. This includes proteins, lipids, carbohydrates and DNA. It also means that in trying to gain stability by capturing the needed electron they don't survive in their original state for very long and quickly react with their surroundings. Hence, free radicals attack the nearest stable molecule, "stealing" its electron. When the "attacked" molecule loses its electron, it becomes a free radical itself, beginning a chain reaction. Once the process is started, it can cascade, finally resulting in the disruption of a living cell.*

Antioxidants are molecules which can safely interact with free radicals and terminate the chain reaction before vital molecules are damaged. Although there are several enzyme systems within the body that scavenge free radicals, the principle micronutrients cannot be processed fast enough to keep up with these free radicals that are occurring each second of the day. This happens more and more as we age, so in effect, our bodies own aging causes the advancement of harmful free radicals and then the free radicals cause us to age faster and over 200 diseases are tied to free radicals so far.*

This is when Protandim comes into play.

The two most important oxygen-centered free radicals are superoxide and hydroxyl radical. They are derived from molecular oxygen under reducing conditions. However, because of their reactivity, these same free radicals can participate in unwanted side reactions resulting in cell damage. Many forms of cancer are thought to be the result of reactions between free radicals and DNA, resulting in mutations that can adversely affect the cell cycle and potentially lead to malignancy. Some of the symptoms of aging such as atherosclerosis are also attributed to free-radical induced oxidation of many of the chemicals making up the body. In addition free radicals contribute to alcohol-induced liver damage, perhaps more than alcohol itself. Radicals in cigarette smoke have been implicated in inactivation of alpha 1-antitrypsin in the lung. This process promotes the development of emphysema.*

Free radicals may also be involved in Parkinson's disease, senile and drug-induced deafness, schizophrenia, and Alzheimer's. The classic free-radical syndrome, the iron-storage disease hemochromatosis, is typically associated with a constellation of free-radical-related symptoms including movement disorder, psychosis, skin pigmentary melanin abnormalities, deafness, arthritis, and diabetes mellitus.*

Science Driven!

Scientists agree that aging and many deadly diseases are the result of cellular deterioration due to rogue molecules called free-radicals .

Free-radical damage is known as Oxidative Stress or Oxidative Damage. Protandim fights the free radicals that cause aging!

PROTANDIM is the only supplement clinically proven to reduce oxidative stress by an average 40%, slowing down the cell aging process to the level of a 20 year-old.* Protandim is not a conventional antioxidant supplement. Each Protandim caplet contains a unique combination of phytonutrients that signal the body's genes to produce its own antioxidant enzymes, which provides thousands of times more antioxidant power than any food or conventional antioxidant supplement.

Your Body's Ability to Battle Aging Decreases As You Age

The aging process is nature's way of limiting the population of every species. It's good for the species, but not so good for the individual. When you're young, your body fights free-radicals effectively by producing its own antioxidants. But as you grow older, your body produces less antioxidants to fight the battles of aging and disease.

Antioxidant Rich Foods & Supplements Can't Keep Up With Free-Radicals.

Protandim provides you with thousands of times more antioxidant power than any food or conventional supplement.* In fact, you would need to consume the antioxidants found in 375 oranges or 87 glasses of red wine or about 120 vitamin C tablets (500mg) a day to neutralize the amount of free radicals your body produces every single day.*

Here's why.

Not all antioxidants are equal. Conventional antioxidant supplements (such as vitamins A, C and E) are known as "consumable" antioxidants because they are used up as they neutralize free radicals on a one-to-one basis. The unique blend of phytonutrients in Protandim signal your body's genes to produce special antioxidant enzymes (SOD and CAT) that work together as the body's first line of defense against free radicals.* These enzymes are "catalytic" , which means that SOD and CAT are not used up when they neutralize free radicals.

A single daily caplet of Protandim creates a cascade of your body's natural catalytic antioxidants that are able to destroy millions of free radicals per second, on a continuous basis - 24/7.

All Natural Ingredients

The natural ingredients in Protandim were specifically chosen based upon their ability to cause the body to produce and up-regulate its natural network of antioxidant enzymes, including SOD and CAT. Protandim has been formulated using high quality, potent herbal extracts processed under proprietary technologies. It therefore provides powerful antioxidant protection against oxidative stress.

The following is a list of Protandim ingredients:

Proprietary Blend 675 mg:

Milk thistle extract (Silybum marianum) (seed) Bacopa extract (Bacopa monnieri) (aerial part) Ashwagandha (Withania somnifera) (root) Green tea extract (Camellia sinensis) (leaf) Turmeric extract (Curcuma longa) (rhizome)

Additional ingredients: Calcium, Croscarmellose sodium, magnesium stearate, microcrystalline cellulose, modified cellulose, silica, stearic acid.

Protandim is 100% Vegetarian

Free of Gluten, Wheat, Dairy, Gelatin and Yeast.

Protandim has been shown in a published, peer reviewed human study to eliminate the age-related increase in cell aging factors!

Protandim is not an antioxidant supplement. It helps your body produce its own antioxidants with thousands of times more antioxidant power than any food or conventional supplement.* and the proof is conclusive.

Aging factors can be measured accurately by the amount of TBARS (thiobarbituric acid-reactive substances) found in the blood. In clinical trials with men and women, young and old, the blood samples consistently demonstrated that after 30 days, taking one caplet a day, test subjects realized a 40 percent average decrease in TBARS - the progressive aging rate of a 20 year old! After 120 days to that of a new born child.

When maintained for 120 days, Protandim significantly increased activity of SOD and CAT antioxidant enzymes by 54 percent, substantially increasing the body's antioxidant defenses.* This is equivalent to that of a new born child.

Protandim Evidence Mounts:

Doctors finally receive clinical proof on a antitoxin supplement that slows down the progressive rate of aging. This new supplement " Protandim" reduces Oxidative Stress by an average of 40 %. Oxidative Stress has been linked to over 200 diseases, such as Cancer, Diabetes, Alzheimer's . Blood Tests have shown that people at any age bring their cellular health to that of a 20 year old after just 30 days of use.

This begins a news release that was issued not long ago leading into yet another story on the growing clinical data supporting the effectiveness of Protandim.

There are presently studies being conducted in over 20 major universities on the impact of Protandim with Oxidative Stress, one of today's hottest medical topics. Dr. Joe McCord is the scientist at the head of much of the data being compiled.

Protandim works differently than other antioxidant supplements. It actually signals the cells in our bodies to produce more of its own antioxidant enzymes, which provide thousands of times more antioxidant power than any food or conventional supplement.

An investigation into Protandim with boys with Duchenne Muscular Dystrophy (DMD) is particularly exciting, according to Dr. McCord. Parents of a number of boys with DMD tried Protandim with their sons and reported significant improvements in strength and endurance as well as cognitive function. DMD is one of over 100 human diseases associated with oxidative stress. DMD, by the way, is a genetic disease and impacts only males.

I share this with you because there is a growing body of evidence about Protandim and the incredible impact that it is having on so many aspects of our health issues. The earning potential for Protandim sales is quite significant given the data now being published. More studies are underway and when they are released, we will share that data with you.

Oxidative Stress:

Oxidative stress, simply put, is the damage made to a cell through the oxidative process.

Oxidation, in itself, is a very normal process - it happens all the time to our bodies and many things that surround us.

However, when there are disturbances in the natural oxidation process, such as the attraction of a free radical to another molecule in your body, the results are often toxic effects.

Imagine an iron pipe lying on the ground. As it weathers years of rain, environmental exposure, sun, and other factors, it begins to rust.

The rust is caused by oxidation. Free oxygen radicals are created during the metabolism of normal oxygen cells, or oxidation. These free radicals are missing a simple electron and are in search of another molecule that they can combine with to become "whole." In their quest, they fire charges that damage other cells and structures around them. This, in turn, causes the rust.

In effect, your body is "rusting" as it goes through its lifetime, the free oxygen radicals wildly running through your system, searching for a mate.

As you can see, the more free radicals your body contains, the more damage that's likely to be done. The best way to see this damage is through our normal aging process.

* Cancer results as the chain damages cell membranes and DNA.

Oxidative Stress and Aging

While modern medicine has found ways for humans to live longer, our quality of life - especially during the last 30 years - has gone down.

Much of this can be attributed to oxidative stress and the toxins that we're encountering more and more throughout our lives.

A simple way to visually experience the effects of oxidative stress on aging is to visit a nursing home. Compare the skin of a five-year-old to that of a resident, and notice the breakdown, wrinkles, and color as compared to the smooth, supple skin of a child.

Throughout our lives, our skin encounters free radicals in many different forms, and their effect is clearly obvious on our skin.

But oxidative stress isn't only apparent on the outside. It's the cause of many or most diseases our society is concerned with today.

Oxidative Stress and Disease

To date, science has discovered that oxidative stress may very well be the cause of over 70 well-known, widely-spread diseases.

Depending on what form of toxin or stress your body is exposed to on an ongoing basis, you could find yourself suffering, even at an early age, from diseases that could be prevented if only you'd have minimized the harmful free radicals in your system.

A Look at Free Radicals

Obviously, even back in the early days of man, free radicals existed and caused oxidative stress. They're inherent to life and a normal byproduct of regular oxygen molecule metabolism. However, our bodies were only made to withstand so much exposure to free radicals (even though our body does an amazing job at neutralizing them in a normal, low-toxin setting).

The increased and prolonged exposure to these wild and reckless free radicals cause a faster build-up of "rust" or disease in our bodies.

So what are some of the most common reasons our bodies' oxygen molecules oxidize themselves into an increased amount of free radicals? Some of them you're probably well aware of, and some of them may come as a surprise.

Environmental & Air Pollution, Cigarette Smoking Excess, Stress Prescription & Over the Counter Medications. Radiation Increased Exposure to Sunlight and Excessive Exercise


Very few individuals, if any, reach their potential maximum life span; they die instead prematurely of a wide variety of diseases--the vast majority being "free radical" diseases.

--Denham Harmon, M.D., Ph.D., who in 1954 first proposed the Free Radical Theory of aging

Honey, take a look at this. You might find it interesting."

Great moments in human history often begin inauspiciously. Such was the case in December 1945, when the wife of Denham Harmon handed him the latest issue of the Ladies' Home Journal. It was opened to an article titled "Tomorrow You May Be Younger," written by William L. Laurence, science editor of the New York Times. This article, heralding the work of a Russian gerontologist on an "anti-reticular cytotoxic serum," sparked Dr. Harmon's interest in finding an answer to the riddle of aging--a subject that scientists of the time knew absolutely nothing about. Even to this day most MD's know very little about Free Radicals/Oxidative Stress.

For the next nine years, Dr. Harmon, a brilliant young organic chemist with a Ph.D. from the University of California, Berkeley, ruminated about the aging process.

Because aging is such a universal phenomenon, he reasoned that it might have a single basic cause. But what could it be? The answer eluded him.

Though still obsessed with the question, he had to place it on the back burner while he completed medical school and an internship at Stanford University. Then one morning in November 1954, during a period in which he was simultaneously completing his residency in internal medicine and doing research at Berkeley's Donner Laboratory, Dr. Harmon's quest ended. That day, while reading in his office, he had an "aha" experience that would revolutionize medical science: "(It) suddenly occurred to me that free radical reactions, however initiated, could be responsible for the progressive deterioration of biological systems." of course, sometimes even the best ideas are slow to be accepted. This one didn't exactly inspire words of praise--not at first, anyway. After thinking it over for a month, Dr. Harmon strolled the Berkeley campus, knocking on doors and presenting his newly formulated Free Radical Theory to his colleagues. To say that it was a hard sell would be an understatement. He might have had more success had he been hawking vacuum cleaners.

The scientists whom Dr. Harmon approached were singularly unimpressed. In fact, all but two flatly rejected his idea. One after another, they slammed the door in the face of the young upstart, who dared challenge the status quo with the preposterous notion that all degenerative disease--and the aging process itself--could be explained by the presence of free radicals.

Undaunted, Dr. Harmon pursued his theory. In subsequent years, he demonstrated how the effects of free radicals are reversed by nutrients known as antioxidants, how antioxidants extend the life spans of laboratory animals, and how antioxidants offer protection against heart disease, cancer, senile brain disease, and all other degenerative conditions associated with aging. Dr. Harmon proved that age-related immune deficiency is caused by free radicals and can be reversed by antioxidants.

In terms of scientific significance, Dr. Harmon's Free Radical Theory ranks with Galileo's invention of the telescope, Newton's discovery of gravity, and Einstein's theory of relativity. No breakthrough has had more profound implications for human health and longevity.

Now in his mid-eighties and still professionally active, Dr. Harmon deserves the Nobel Prize for his revolutionary work.

Free Radicals: Longevity's Most Formidable Foe

Dr. Harmon's Free Radical Theory has emerged as the best understood and most widely accepted explanation of the aging process. Having stood the test of time and countless research validations, it has become not just a damage theory but the damage theory. (You'll recall from chapter 1 that according to damage theories, cumulative cellular damage determines a person's age of death.) In fact, among doctors specializing in anti-aging medicine, Free Radical Theory has transcended mere theory status and is considered a biological fact of life.

Just what are these free radicals, anyway? Understanding where they come from, and why and how they do so much damage, requires a brief lesson in biochemistry.

Molecules are made up of atoms glued together by chemical bonds. Each bond consists of a pair of electrons. When a bond is broken, what's left are two molecular fragments, each of which contains one of the now unpaired electrons. These molecular fragments are highly charged and highly unstable, because they contain only one electron rather than two. These highly charged, highly unstable, highly reactive particles are what we know as free radicals.

Unfortunately for us humans, the biochemical saga of free radicals doesn't end there. Remember, each free radical contains one unpaired electron. And unpaired electrons, like unpaired humans, hate to be alone. They want a partner, and they're not above breaking up another bond to get what they want. Scientists call this process oxidation, and free radicals are masters at it. They're not particularly discriminating about where they get their new partners, either. They'll oxidize just about anything that gets in their way--punching holes in cell membranes, destroying key enzymes, and fracturing DNA.

What's more, free radicals are remarkably prolific. One free radical, unchecked, can cause new ones to form. These free radicals, in turn, give rise to many more. How does this happen?

Because it has so much energy, a free radical zips about until it bangs into a nearby molecule with a stable bond. The collision splits the stable molecule, releasing one of its two electrons. The free radical nabs the electron as a partner for its own unpaired electron, and the two form a stable bond. All this happens, quite literally, within nanoseconds.

The good news is that the free radical has stabilized itself. The bad news is that in doing so, it may have caused the formation of two more free radicals by breaking a stable bond, leaving the two atoms of the formerly stable molecule to share one unpaired electron. So begins a chain reaction that produces thousands of molecular fragments with unpaired electrons. And every one of these fragments is careening about, looking to swipe an electron from an unsuspecting stable molecule.

To get a clearer understanding of how free radicals multiply, imagine a football stadium filled to the brim with mousetraps, each mousetrap loaded with a Ping-Pong ball. If you drop one Ping-Pong ball into the stadium, it springs one mousetrap, causing it to fling its ball into the air. Then you have two loose Ping-Pong balls, which spring two more mousetraps. Within a matter of seconds, all of the mousetraps are sprung, and all of the balls are loose.

Now if all those mousetraps were stable molecules, and all those Ping-Pong balls were free radicals, you would have just witnessed a free radical free-for-all.

Cellular Sabotage

In their reckless quest for electrons, free radicals do a lot of structural damage to healthy cells. Injured cells can't function properly and may even die.

Most vulnerable to free radical attack is the cell membrane, which surrounds each cell and guards its jellylike interior. The cell membrane is a sophisticated, highly selective barrier whose all-important job is to guard access to the cell. It decides what gets in, what stays in, and what is expelled (forcibly, if need be). If cells were nightclubs, then cell membranes would be bouncers.

Inside each cell are many subcellular structures called organelles. Each organelle is wrapped in its own protective outer membrane and performs a highly specialized function. Mitochondria, for example, transform oxygen and food into energy, which the cell uses to carry out its tasks. Lysosomes scarf up and digest cellular garbage, which is then either recycled or jettisoned. The cell's nucleus is also an organelle. It houses DNA, the cell's genetic blueprint.

When a cell membrane or an organelle membrane is damaged by free radicals, it loses its protective properties. This puts the health of the entire cell at risk.

The cell membrane is a pushover for free radical attack because it is composed primarily of easily oxidized fatty acids. Like tiny but powerful bullets, highly charged free radical particles rip into the cell membrane, literally puncturing holes in it. A damaged cell membrane loses its selectivity. When this happens, transportation of nutrients, oxygen, and water into the cell and removal of waste products from the cell become compromised.

In much the same way, free radical damage to an organelle's membrane sabotages the organelle's function. When mitochondria are injured, for instance, these submicroscopic power plants can't produce the energy necessary to drive the cell's machinery. If damage to the mitochondrial membrane is extensive, the cell dies.

Free radicals can even bang their way through the protective membrane surrounding the nucleus, gaining access to the DNA molecules housed inside. If free radicals happen to break the DNA molecules in order to snatch electrons, the cell dies, or loses its ability to replicate, or replicates abnormally--a process known as mutation. Mutation can give rise to the collections of abnormal cells that we know as cancer.

But cancer isn't the only health problem for which free radicals are responsible. Cumulative free radical damage contributes to all sorts of organ- and tissue-specific diseases, including allergies, Alzheimer's disease, arthritis, atherosclerosis (hardening and clogging of the arteries), cancer, cataracts, infections, macular degeneration, multiple sclerosis, and Parkinson's disease. In fact, researchers now agree that most common ailments, including virtually all chronic degenerative diseases, are either caused directly by or are closely associated with free radical damage.

Immune Cells: Dedicated Defenders

Of all the cells in your body, immune cells are the most likely victims of free radical attack. Ironically, they put themselves at risk just by carrying out their assigned task.

Immune cells scavenge free radicals. If injured, immune cells are less able to do their job. In the short run, their impairment usually doesn't produce symptoms. Over time, persistent fatigue, recurrent infections, and allergies may be among the first signs of immune erosion.

If free radicals continue their attack on immune cells, and if the cells never get a chance to heal, the accumulated damage weakens the immune system even more. Eventually, this opens a potential Pandora's box of disorders caused by altered immune function. Free radical damage to an immune cell's protective outer membrane or DNA can be especially ominous.

Once damaged, an immune cell loses its ability to differentiate between good guys and bad guys. One of two scenarios, neither good, then unfolds. In the first, immune cells mistake friends for foes and begin attacking healthy tissues. This is known as an autoimmune disease, examples of which include lupus, multiple sclerosis, and rheumatoid arthritis. In the second scenario, immune cells mistake foes for friends. For example, they may fail to recognize cancer cells and, rather than annihilating them, ignore them and allow them to multiply.

The Link to Aging

Prolonged exposure to free radicals actually fast-forwards the aging process. One of the clearest manifestations of cumulative free radical damage is a phenomenon known as cross-linking.

Cross-linking affects protein, enzyme, DNA, and RNA molecules. A bit like handcuffing, it hampers the ability of its molecular hostages to perform their assigned tasks. In this way, cross-linking works to the detriment of the entire organism--especially if that organism happens to be your body. Because of cross-linking, the elastic, flexible tissue of youth gives way to the wrinkled skin, stiff joints, and hardened arteries of old age.

What's more, cross-linking worsens with age, as the cellular wear and tear of several decades accumulates and the body becomes less adept at scavenging free radicals. The result is the general, body-wide impairment of function that's synonymous with degenerative disease and aging.

In skin cells, the cross-linking of molecules causes the wrinkles characteristic of aging. In arterial cells, cross-linking reduces flexibility, which in turn raises blood pressure and puts extra strain on the heart as it pumps harder to maintain a continuous flow of blood. In the brain, cross-linking impedes message transmission between nerve cells--not good if you prefer crisp thinking and a rapid flow of ideas. Thought processes slow down, and memory and concentration problems are more likely.

For all of cross-linking's dirty work, its effects on DNA molecules may be most problematic. When these molecules are damaged, they compromise the cell's ability to correctly interpret its DNA-encoded genetic blueprint. This results in impaired DNA replication and protein assembly. The entire process of Renewal depends on cells being able to replicate themselves exactly. This is why the failure to protect a cell's genetic coding has particularly profound consequences.

Meet the Free Radical Formers

Since free radical damage fosters disease and shortens life, it stands to reason that we need to know not only where these rogues come from but also how to avoid them--or at least limit our exposure.

Unfortunately, free radicals are everywhere. They're in the foods we eat, the water we drink, the air we breathe. Even our bodies produce free radicals.

Our bodies are equipped to rein in and dispose of free radicals. The problem is that we usually have more of these troublemakers floating around than our bodies can manage. And that's when we run into problems.

Any combination of factors that produces excessive free radicals (or suboptimal scavenging) can ultimately cause mass destruction throughout the human body. This destruction has been linked to the development of disease and the acceleration of aging.

True, some sources of free radicals we can't control. But many we can. Here's a rundown of the primary offenders.

The Most Surprising Source

As you read this sentence, your body is generating humongous quantities of free radicals. And believe it or not, it's quite normal.

You see, these free radicals are a kind of cellular "exhaust"--a by-product of metabolism. They're produced as cells use oxygen to convert food into energy. The only way to avoid these free radicals would be to stop burning oxygen. But then your metabolism would shut down, too.

Because these free radicals are really your body's own doing, your body expects them and is designed to deal with them. It has highly efficient ways of grabbing and neutralizing these renegade particles before they can do harm. So your cells just keep on making them.

The Usual Suspects

The free radicals that occur naturally within your body should be no cause for concern. It's the excess free radicals, the ones that your body is not prepared to handle, that cause life-shortening damage. This extra load results from two key factors: an overabundance of toxins and a shortage of antioxidants (more on these later).

A complete list of all the external sources of free radicals would likely run on for pages. So here are a few of the more pernicious offenders.

The standard American diet. The standard American diet is a free radical fiasco just waiting to happen. It's liberally laced with high-fat, processed, preserved, pesticide-laden, chemically treated foods. It's chock-full of known free radical formers such as meat, butter, margarine, sugar, white flour, and alcohol. It emphasizes frying, browning, and other cooking methods that exponentially drive up the free radical count. Most significant of all, it's dangerously deficient in antioxidant-rich, free radical fighting fruits and vegetables.

A high-fat diet. Consuming more than 10 percent of your calories from fat dramatically increases your body's free radical load. The reason: When bombarded by free radicals, fat molecules split apart easily. The weak bonds that hold together polyunsaturated fat molecules are especially sensitive to and readily broken by heat, light, or oxygen. The more fat you ingest, the more free radicals your body generates. This is why heart disease and cancer, two conditions associated with cumulative free radical damage, are most common in people who consume high-fat diets.

Trans-fats. Also known as funny-fats or ugly fats (because of what they do to the body), trans-fats are seething cauldrons of free radical activity. They're created by cooking at high heat and by hydrogenation (the process used to harden liquid vegetable oils). Most people get their trans-fats from the margarine they spread on their morning toast, the shortening in most baked goods, and the hydrogenated oil in processed and convenience foods (such as crackers, chips, and nuts). The average American ingests 100 pounds of trans-fats annually, a tremendous free radical load.

Chemicals. Some of the nastiest and most pervasive free radicals come from the vast and expanding array of toxic chemicals being released into the environment. Chlorination of water supplies spawns often dangerous levels of chloroform and trihalomethanes, both powerful free radical formers. The air is also saturated with free radical formers: oxides of sulfur and nitrogen, ozone (which is beneficial to humans only if it stays in the upper atmosphere), chlorine, aromatic hydrocarbons (such as benzene and toluene), formaldehyde, carbon monoxide, lead, asbestos, and tobacco smoke. The combustion of tobacco alone creates thousands of different free radical generating chemicals. Even if you don't smoke, you may have a hard time escaping from secondhand smoke.

Pesticides. Pesticides are notorious free radical formers. They're also very soluble in fat. This means they're found in much larger quantities in foods of animal origin, which are naturally high in fat, than in foods of plant origin. Why? Well, an animal eats pesticide-sprayed feed every day over the course of its lifetime. The pesticide residues become concentrated in the animal's fatty tissues, the result of a vain attempt by the animal's body to remove the toxic substances. Then when you eat food from that animal--be it steak, chicken, milk, cheese, or butter--your body likewise tries to rid itself of the toxins by storing them in fatty tissues. Hidden away, the pesticide molecules eventually initiate free radical chain reactions. This phenomenon helps explain the epidemic of heart disease and cancer among meat-eaters.

Radiation. Ionizing radiation--including medical and dental x-rays, radon gas, and ultraviolet radiation from the sun--fractures stable molecules. In doing so, it creates free radicals. Cells are extremely sensitive to radiation, with the cell membranes and the chromosomes in the nuclei at highest risk for damage. And radiation doesn't have to be strong to do harm: Exposure so weak that it destroys only one molecule in 100 million can nevertheless trigger free radical chain reactions capable of killing an entire cell. And if radiation scores a direct hit on a cell's nucleus, the cell's DNA--the blueprint for cell replication--becomes damaged.


Victoria Johnson Center for Lung Research, Virginia Commonwealth University, Richmond, VA 23298, USA. nvoelkel@mcvh-vcu.edu



Pathobiological mechanisms that contribute to pulmonary vasoconstriction, lung vascular remodeling, and the development of right heart failure include the generation of reactive oxygen and nitrogen species and the response of lung vascular and cardiac cells to these molecules. We review the information regarding oxidant stress balanced by antioxidant mechanisms and the role of oxidants and antioxidants in hypoxic pulmonary hypertension and their potential role in an animal model of severe pulmonary arterial hypertension (PAH).


In human lung tissue from patients with idiopathic PAH, we find reduced superoxide dismutase activity and high expression of the oxidant stress markers nitrotyrosine and 8-OH-guanosine. In the Sugen 5416/chronic hypoxia model of PAH, lung tissue expression of nitrotyrosine and hemeoxygenase 1 (HO-1) is substantial, while HO-1 expression in the failing right ventricle is decreased. This model, based on administration of the VEGF receptor blocker Sugen 5416 and chronic hypoxia (Su/Hx), reproduces many of the characteristic features of severe angioobliterative human PAH. Treatment of Su/Hx rats with protandim, which nuclear factor erythroid-2 related factor (Nrf2)-dependently upregulates the expression of genes encoding antioxidant enzymes, protects against right heart failure without affecting angioobliterative PAH.


In human severe PAH, patient survival is determined by the function of the stressed right ventricle; investigation of oxidative and nitrosative stresses and their potential contribution to right heart failure is necessary.


Antioxidant therapeutic strategies may be of benefit in the setting of human severe PAH. Whether antioxidant strategies affect lung vascular remodeling and/or prevent right heart failure remains to be examined.

Sources of Free Radicals

Avoiding free radical formers may seem like an easy enough task. But the reality is, they're just about everywhere. The following list provides a mere sampling of substances and other factors that can cause a free radical overload. How many of these do you encounter every day?

General Factors




Dietary Factors




Foods of animal origin

Foods that have been barbecued, broiled, fried, grilled, or otherwise cooked at high temperatures

Foods that have been browned or burned


Hydrogenated vegetable oils



Chemical Factors

Air pollutants such as asbestos, benzene, carbon monoxide, chlorine, formaldehyde, ozone, tobacco smoke, and toluene

Chemical solvents such as cleaning products, glue, paints, and paint thinners

Over-the-counter and prescribed medications

Perfumes, Pesticides

Water pollutants such as chloroform and other trihalomethanes caused by chlorination


Cosmic radiation

Electromagnetic fields

Medical and dental x-rays

Radon gas

Solar radiation


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Dear Mr. Brightman,

I've been taking Protandim about four months. Since I began, I've noticed many things. The very first thing I noticed was stronger muscles that were a lot less sore the day after exercising. I haven't lost any weight but I've firmed up quite a bit. My skin is firmer and holds more moisture now therefore, I have seen some fine lines disappear on my face.

In addition, the stressful days at the office don't wear me down like before. Also, I have increased energy, better sleep, more hair, more balanced hormones, and definitely an increased sense of well being. I am very excited about Protandim and look forward to seeing more positive changes in my body.

Thanks for introducing me to Protandim and offering me fantastic business

opportunity too.


Julie S.


Dear Bruce,

My husband and I have been taking Protandim now since October 23rd, 2009. After only 2 weeks he asked me if I noted any changes in myself. Until he asked I wasn't really aware, but I noticed my prescription glasses were blurry and I could see better when I took them off. My vision was so clear it was sometimes very stark to look about. My husband noticed he no longer had difficulty driving at night, and we drove straight through the night to Iowa, that was amazing. Then we both noticed the snoring had completely gone away. The last thing I noticed and we have been taking Protandim now for approximately 2 months, was all the age spots I had on both my forearms have completely faded or disappeared.

We are now watching and waiting for more changes as we continue on this program. We have so many friends that have lost jobs just this past year and are without insurance. Protandim is the answer to all of this.


Craig & Linda


Hello Bruce,

I began using the product personally on November 6. I have been tracking my blood pressure, body temperature, weight, and urine ph daily (missing a few day here and there.) I wanted to have some first hand results to share with others. After about 6 weeks, my blood pressure has gone down from an average of over 175/100 to about 143/86. My ph was in the 5.5-5.9 the first few days but has increased to the 6.3-6.8 range with several days logging in at over 7.0. My weight has decreased from about 230 to 224 with no other dietary changes. We have also been giving Protandim to my 95 year old father-in-law who lives with us and believe we are seeing improvement in his mental clarity and awareness. My wife and our grandson are also taking the product and I can only say that we all seem to notice an overall improvement in our sense of well-being. I remain excited about the health benefits of Protandim and look forward to the same excitement of the business side.

I look forward to hearing from you.

Randy W.


I would like to take this time to thank the LifeSource team for being such an inspiration to us. My son, Eddie, started ordering from LifeSource a few years ago and became a distributor as well. When Eddie shared his catalog with me at that time, I was so impressed with all that was offered. I was originally reluctant to order anything until I saw the difference the products he was using made thus prompting me to begin ordering. The rest is history! Eddie and I both are so encouraged that LifeSource is powered by God as it certainly shows when talking with the staff at LifeSource specifically the founder and Laura (and I hope I have her name correct!). May God continue to bless you richly in all you do!

Blessings and In Him!

Carolyn Ward

I congratulate all of you who have taken the time to read the immense scientific research on Protandim written above - a product that I believe has the potential to truly change lives.

My goal at LifeSource has always been to help people live a longer, healthier life and to be diligent to God. I have always believed God is guiding me on my path in life and He is lighting the way of my future ("Thy Word is a lamp unto my feet, and a light unto my path. Psalm 119:105").

May God bless you and your loved ones always!

With Christ,

Bruce Brightman, Founder

LifeSource Vitamins


E-mail Us: info@LifesourceVitamins.com

or Call Us: 800.567.8122

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LifeSource Vitamins: Since 1992

*Disclaimer: None of the above statements have been evaluated by the FDA. These products are not intended to diagnose, treat, cure or prevent any disease. As always, consult your physician before taking any and all supplements. LifeSource Vitamins. Individual results may vary.

Disclaimer: All the information contained throughout this website is based upon the opinion of the founder of LifeSource Vitamins, Bruce Brightman, and the entire team at LifeSource Vitamins whose relentless research and studies have been ongoing on since 1992. Other articles and information are based on the opinions of the authors, who retains the copyright as marked on the article. The information on this site is not intended to replace your health care professional, but to enhance your relationship with them. Doing your own studying and research and taking your health care into your own hands is always best, especially in partnership with your health care professional. If you are pregnant, nursing, taking medications, or have any medical conditions, always consult your health care professional before taking supplements based on the information on this site.

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