Policosanol 10 mg
90 Veg Caps
Policosanol has been touted as a dietary supplement that
can lower cholesterol as well as statin drugs, without the side effects.
Studies indicate that it works by inhibiting cholesterol
formation in the liver. * More clinical studies below….
A typical dosage of policosanol used in studies has been 5
to 10 mg two times a day. Studies generally found that it can take up to two
months to notice benefits. So do not be fooled by other information floating
out there. Policosanol works by itself. Nothing more is needed in this pill,
just 10 mg of Policosanol.
Marcia Angell, former editor of the New England Journal of
Medicine and author of "The Truth About the Drug Companies" gives us
some revealing clues:
The makers of Lipitor and Zocor alone spent
$150 million on advertising in one year alone in 2000.
The pharmaceutical giants employed 88,000 sales
representatives in 2001 to "visit" doctors, promote their products
and provide them with free samples. That comes out to one drug rep for every 6
Medical protocol dictates that statin drugs are
automatically prescribed as the "standard of care" regardless of the
Physicians have never studied the Policosanol
research. Most doctors know little or nothing about the Policosanol benefits.
Recent Policosanol Benefits Clinical Studies
Policosanol shown to be more effective than Zocor and other
Reported in New Hope Natural Media, 6/6/02
"In a six-month study, 10 mg per day of Policosanol
reduced total cholesterol by 16% and LDL cholesterol by 24%, and increased HDL
cholesterol by 29%."
Several other studies have compared this cholesterol
lowering supplement with some of the conventional medications used to reduce
cholesterol and the results have shown that of 5 to 20 mg per day to be more
effective than Lovastatin (Mevacor®), pravastatin (Pravachol®)and Simvastatin
Double Blind Study Comparing Policosanol to
In a 1997 head-to-head study Policosanol was compared with
statin drugs lovastatin (Mevacor), simvastatin (Zocor) and pravastatin
Policosanol and ZOCOR were found to be equally effective in
lowering cholesterol during an eight week study...but Policosanol benefits also
included significantly increased HDL-cholesterol levels and Zocor did not.
The side effects of these statin drugs
of California San Diego Study.
The following study which was put together by a group of
scientists, doctors and students at the University Of California San Diego
School Of Medicine pulls no punches in analyzing the side effects of Lipitor,
Zocor, Crestor, Vytorin and similar statin drugs.
Changes in liver function.
Muscle symptoms are common Lipitor side
Memory and Concentration. Some people report
changes in memory, attention, or concentration on statins. Some describe
"holes in their memory" and worry that they are developing
Depression and Irritability. Many people report
depression and changes in mood as Lipitor side effects.
Low serotonin has been reported as another side
effect of statin drugs.
Tough time swallowing.
Headaches, Joint and Abdominal Pain.
Sleep problems, sexual function problems,
fatigue, dizziness and a sense of detachment are also reported Lipitor side
These Policosanol benefits are not found in
statin drugs such as Lipitor and its generic cousins.
Policosanol doesn’t interfere with sex life as
statins often do.
Policosanol increases protective HDL
cholesterol levels. Most statin drugs do NOT improve HDLs. HDL cholesterol
levels typically increase by 15 to 25% after only two months of Policosanol
The "good" HDL cholesterol is the
"Superman" heart protector. HDL cholesterol acts like a miniature
hydraulic vacuum cleaner, streaming through your arteries scooping up the
heart- stopping LDL cholesterol, and carrying it back to your liver where it
can be dealt with.
1. HDLs also douse the fires of inflammation. It is this
smoldering inflammation and oxidation that causes the cholesterol in our
arteries to turn rancid and clog our arteries.
2. Scientific studies also show that people with the
highest levels of HDL cholesterol live longest!
New studies show that oxidation and inflammation are more
important contributors to artery clogging than just high LDLs alone.
Lowers Lp(a) cholesterol. Numerous researchers
say this is the "worst" form of cholesterol.
Reduces platelet aggregation (stickiness) which
lowers risk of arterial blood clots.
Improves intermittent claudication (pain in the
leg muscles due to inadequate blood supply).
This all natural supplement may prevent and
reverse atherosclerotic lesions and thrombosis (clotting).
Policosanol safe and side effect free?
One of the best Policosanol benefits is the lack of
negative side effects. In studies of 27,879 patients (17,225 patients for two
years and 10,654 patients for four years), only 86 patients (0.31%) reported
adverse effects, the most frequent of which was weight loss.
Numerous clinical trials show that elderly
persons, diabetics and those with liver damage can safely take Policosanol.
Studies show that this all natural product made
from sugar cane DOES NOT affect blood thinning and there is no interaction
between Policosanol and blood-thinning medication such as warfarin.
A mixture of higher aliphatic primary alcohols
derived from sugar cane wax has become popular in such places as Cuba for its
reputed cholesterol-lowering benefits, energizing effects and enhancement of
sexual function. It is also the source of another increasingly popular
supplement--octacosanol (the primary long-chain alcohol in policosanol).
There are a number of animal studies
suggesting that policosanol can lower cholesterol, that it can inhibit
experimentally induced atherosclerotic lesions of cerebral ischemia, that it
can help prevent the peroxidation of lipoprotein and inhibit platelet
Human studies have been increasing. In one recent
study, patients with LDL-cholesterol greater than 160 mg/dl were randomized in
double-blind fashion to receive policosanol (10 milligrams daily), lovastatin
(20 milligrams daily) or simvastatin (10 milligrams daily). After eight weeks
of therapy, LDL-cholesterol was reduced 24% in the policosanol groups, 22% in
the lovastatin group and 15% with simvastatin. HDL-cholesterol increased
significantly in the policosanol group but not in the other two groups.
Policosanol was judged to be "a safe and effective cholesterol reducing
agent." In another recent double-blind study of policosanol's possible
effects in hypercholesterolemia, patients received 5 milligrams of policosanol
or placebo daily for 12 weeks followed by 10 milligrams of policosanol or placebo
for a subsequent 12 weeks. Policosanol (5 and 10 milligrams daily) appeared to
significantly reduce LDL-cholesterol (18.2% and 25.6% respectively) and reduce
cholesterol (13% and 17.4%). It appeared to raise HDL-cholesterol (15.5% and
28.4%). Triglycerides were unchanged in the first 12-week period but were
significantly reduced (5.2%) by the end of the second 12-week period.
Side effects were few and minor. There were 11
serious (7 of these were vascular) adverse events among those taking
policosanol. Policosanol appears to significantly reduce platelet aggregation
in both healthy and hypercholesterolemic individuals, apparently proving as
effective (at 20 milligrams daily doses) as aspirin (100 milligrams per day).
The substance also appears to demonstrate beneficial effect in patients with
intermittent claudicating. Long-term therapy (20 months) using 5 milligrams of
policosanol twice a day resulted in significant improvement in treadmill
exercise performance and exercise — ECG responses in a group of coronary heart
disease patients. The addition of 125 milligrams of aspirin daily further
enhanced these results. It is hoped that others will confirm these very
promising, largely Cuban studies.
Policosanol's reputed efficacy in boosting
energy and enhancing sexual function, particularly male sexual function, is
Policosanol is not recommended for children,
pregnant women and nursing mothers. Because of possible antithrombotic
activity, those taking warfarin and hemophiliacs should exercise caution in the
use of policosanol. Policosanol supplementation should be stopped before any
Mild gastrointestinal side effects, skin rash,
headache, insomnia and weight loss have been reported. The incidence of these
adverse reactions is low. Policosanol is generally well tolerated.
Except for possible lowering of serum total
cholesterol and LDL-cholesterol, policosanol does not appear to affect any
other laboratory test results.
Hypercholesterolemia The majority of
policosanol research is on patients with type II hypercholesterolemia. Fifteen
randomized, placebo-controlled, double-blind studies have shown positive
results. (15-29) Significant decreases in total cholesterol (TC) (8-23%), LDL
(11.3-27.5%), LDL/HDL (15.3-38.3%), and TC/HDL (9.1-30.5%) were observed in all
trials. Of the 13 trials measuring HDL, seven showed significant increases and
in six HDL was unchanged. Doses ranged from 2-40 mg/day, with decreases in TC,
LDL, LDL/HDL, and TC/HDL and increases in HDL being dose-dependent up to 20
mg/day, with no further benefit at 40 mg/day. However, 40 mg/day significantly
decreased triglycerides (TG), which was not seen with lower doses. (28)
Policosanol was effective in three studies on
patients with type 2 diabetes mellitus and hypercholesterolemia. (30-32) All
three trials used 5 mg twice daily for 12 weeks. Total cholesterol was reduced
by 14-29 percent, LDL was reduced by 20-44 percent, LDL/ HDL ratio was reduced
by 24-52 percent, and HDL was increased by 8-24 percent. No adverse effect on
glycemic control was noted in any of the studies. In trials comparing
policosanol with lovastatin (20 mg/ day), policosanol performed significantly
better at raising HDL and lowering the LDL/HDL ratio. (32,33)
Two studies with a total of 300 patients
indicate policosanol is effective in postmenopausal women with hyperlipidemia.
(34,35) Both studies started with 5 mg daily, which was later increased (at
week 8 in one study. (34) and week 12 in the other (33)) to 10 mg daily for a
period of eight or 12 more weeks. At the end of the 5-mg portion, TC, LDL,
LDL/HDL, and TC/HDL decreased by 13-20 percent, 17-18 percent, 17.0-17.2
percent, and 16.3-16.7 percent, respectively, whereas HDL was unchanged in one
trial and increased by 16.5 percent in the other. At the end of the 10-mg/day
period policosanol supplementation resulted in decreased TC, LDL, LDL/HDL, and
TC/ HDL by 17-20 percent, 25-28 percent, 27-30 percent, and 21-27 percent,
respectively, and increased HDL 7-29 percent. Significantly more side effects
were seen in the placebo group in each trial.
In comparative trials policosanol generated lipid profiles similar to
simvastatin, (36,37) pravastatin, (10,38) lovastatin, (32,35,39) probucol, (40)
acipimox, (41) and atorvastatin. (42) First, two trials on patients with type
II hypercholesterolemia, comparing low dose simvastatin (5 or 10 mg/day) and
moderate dose policosanol (5 or 10 mg/day), demonstrated that both substances
greatly improved lipid profiles with no significant differences in results or
side effects between the groups. (36,37) Second, policosanol (10 mg/day)
compared favorably to low-dose pravastatin (10 mg/day) in patients with type II
hypercholesterolemia in two studies. (10,38) In one trial. Policosanol-treated
patients had significantly greater decreases in LDL, LDL/HDL, TC/HDL, and
increases in HDL, (38) while in another trial policosanol-treated patients had
significantly greater increases in HDL. (10) The pravastatin group had more
side effects in both studies. A study comparing policosanol to lovastatin in
patients with type 2 diabetes and hypercholesterolemia (type II) found
policosanol (10 mg/ day) is more effective at lowering LDL/HDL and increasing
HDL than 10 mg/day lovastatin, with significantly fewer side effects. (32) In
addition, in patients with type II hypercholesterolemia and concomitant
coronary risk factors, policosanol (10 mg/day) decreased LDL/HDL and increased
HDL more effectively than 20 mg/day lovastatin, with fewer side effects. (39)
Policosanol (5 mg twice daily) also compared favorably to probucol (500 mg
twice daily) at reducing TC, LDL, and TG in patients with type II
hypercholesterolemia. (40) Again, policosanol (10 mg/day) compared favorably to
acipimox (750 mg/day), a niacin derivative, in regard to TC, LDL, LDL/HDL,
TC/HDL, and HDL, with fewer side effects. (41) Lastly, policosanol was
significantly less effective than atorvastatin (Lipitor) in reducing both LDL
and TC, although it was similar in reducing both atherogenic ratios and TG.
Atorvastatin, however, significantly increased (p < 0.05) creatine
phosphokinase (CPK) and creatinine, whereas policosanol significantly reduced
alanine aminotransferase (AST), glucose (p < 0.01), and CPK (p < 0.05)
levels. (42) These studies suggest a therapeutic benefit to policosanol in type
II hypercholesterolemia, while presenting no adverse effects on the liver.
Vitamins - Policosanol - 90 Veg Caps, a dietary supplement that can lower
cholesterol just as well as statin drugs, without the side effects,
Cardiovascular Support, lowering cholesterol, cholesterol support,
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product exceeds the standards and requirements set forth in the FDA's Code of
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products are not intended to diagnose, treat, cure or prevent any disease. As
always, consult your physician before taking any and all supplements.
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team at LifeSource Vitamins whose relentless research and studies have been
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