Cervical dysplasia may be defined as pre-invasive neoplastic epithelial
changes in the transformation zone of the uterine cervix often associated
with human papillomavirus infections.( 1)
It is also known as cervical intraepithelial neoplasia, (CIN) or noted in
reference to pap smear as squamous intraepithelial lesion (SIL). It is
classified into categories of mild, moderate, or severe.
Mild dysplasia (CIN I or SIL low grade) is limited to cellular changes in
the lower one-third of the squamous epithelium. Moderate dysplasia (CIN II
or SIL high grade) includes cellular changes in the lower two-thirds of the
squamous epithelium, and severe dysplasia (CIN III or SIL high grade or
carcinoma in situ) involves the full thickness of the squamous epithelium.
The risk of cervical dysplasia, and cervical neoplasia is higher for women
with multiple partners, women who's sexual partners are more promiscuous,
and women whose first sexual intercourse was at an early age.( 2)
Many studies have linked the number of sexual partners as a strong risk
factor for both pre-invasive and invasive lesions of the cervix. Several
epidemiologic studies have provided evidence supporting an association
between cigarette smoking and CIN and invasive cervical cancer.( 3)
Most studies have shown a two-fold increased risk for cervical neoplasia
among smokers and a dose-response relationship with the duration and
intensity of smoking.( 4)
Nutritional factors have been implicated in 60% of cancers in women and 40%
of cancers in men.( 5)
Several lines of evidence suggest that some nutrients may have a protective
effect against cervical neoplasia, particularly Vitamin A, carotenoids,
vitamin C, vitamin E, and folic acid.( 6)
Comparison of such studies is difficult, however, due to use of different
methods of nutrient measurement (dietary intake by food frequencies, food
records, or 24h recall diet; tissue, serum, or red blood cell levels),
selection of comparison groups, methods of diagnosis, and control of
In recent years, the risk of cervical dysplasia has shown strong linkage to
human papilloma viruses type 6,11,16,18,31,and 35.
HPV infection has been strongly associated with the development of
dysplasia and cancer of the uterine cervix. More than 90% of cervical
cancers contain DNA of oncogenic (high-risk) HPV types such as 16,18, and
) HPV DNA is also present in the precursor lesions of cervical cancer
The top 7 vitamins and supplements shown to help Cervical Dysplasia:
Prescription for Natural Cures
by James F. Balch, M.D. and Mark Stengler, N.M.D.
Super Prescription # 1
– LifeSource Product
Take 1,000 to 5,000 mcg daily, preferably in sublingual form. It is best
taken in conjunction with a multivitamin or B-Complex formula that contains
the full spectrum of B vitamins. This is an important nutrient for women
with a history of oral contraceptive use. B12 is involved in healthy cell
Super Prescription # 2
– LifeSource Products
Take 2,000 to 10,000 mcg daily. Folate is involved in healthy cell
replication. This is an important nutrient for women with a history of oral
contraceptive use. Higher doses of folate are available through holistic
doctors. L-5 methyltetrahydrofolate is preferred form.
Super Prescription # 3
Indole-3-carbinol (I3C) or Diindolylmethane (DIM
Take 200 to 400 mg of I3C and/or 200 mg of DIM. These substances are
extracts from cruciferous vegetables that support the removal of excess
estrogen, which may worsen HPV infection, and that appear to help cervical
Super Prescription # 4
– LifeSource Product
Taking 300 mg daily in capsule form has shown to be effective. Green-tea
suppositories are also effective and are available from a holistic doctor.
Super Prescription # 5
– LifeSource Product
Take 75,000 IU twice daily of a mixed natural-carotenoid complex. Your skin
may turn an orangish hue from the high levels of carotenes, but do not be
concerned; the carotenes are nontoxic.
Super Prescription # 6 Homeopathic conium maculatum (hemlock)
Take a 6x, 12x, 6C, 12C, or 30C potency twice daily for two weeks. This is
best regression of their use under the guidance of a trained homeopathic
Super Prescription # 7
– LifeSource Product
Take 400 IU of mixed vitamin-E complex containing tocopherols and
tocotrienols. A low level of vitamin E is associated with an increased risk
of cervical dysplasia.
Click here to see all products, articles and studies for Cervical
Most frequently patients with cervical dysplasia are asymptomatic. Cervical
dysplasia may occasionally be associated with condyloma acuminatum in the
vulva, vagina, or anus, or the presence of co-existing sexually transmitted
diseases of the lower reproductive tract such as chlamydia or gonorrhea.
Frequently patients are asymptomatic. Occasionally there is association
with condyloma acuminatum in the vulva, vagina or anus. Occasionally there
are co-existing sexually transmitted diseases in the lower reproductive
Some of the following laboratory testing can provide information necessary
for diagnosis and treatment. In addition, the tests listed may also give
insight to functional metabolism and functional nutrient status in the
The balance of these hormones appears to be important in cervical
This test offers a high probability of identifying cervical dysplasia and
should be part of any evaluation of this condition.
Folic acid testing should be done to assess body folic acid status. Red
Cell Folate levels has been traditionally used to determine folate status.
However, a functional test called the Neutrophilic Hypersegmetation Index
provides a more accurate determination of each individual woman's folic
acid status and requirements.
1. Shiu AT. Cervical dysplasia. In: Dambro MR ed. Griffith's 5-minute
Clinical Consult. Philadelphia: Lippincott, Wlliams, & Wilkins;
2. Munoz N. Bosch FX: Epidemiology of cervical cancer. IARC Sci Publ.
3. Wilkenstein W. Smoking and cervical cancer--current status: A review. Am
J Epidemiol. 1990;131:945.
4. View Abstract: Brinton LA. Epidemiology of cervical cancer-overview.
IARC Sci Publ. 1992;119:3.
5. View Abstract: Schneider A, Shah K. The role of vitamins in the
etiology of cervical neoplasia: An Epidemiologic review. Arch Gynecol
6. View Abstract: Morris M, Tortolero-Luna G, Malpica A, et al. Cervical
intraepithelial neoplasia and cervical cancer. Obstet Gynecol Clin North
Am. Jun1996;Vol 23(2):347-410.
7. American Cancer Society. Cervical cancer fact sheet. Revised. Feb2000.
8. Reichman RC. Human Papillomavirus Infections, In: Fauci AS, Braunwald E,
Isselbacher KJ, et al, eds. Harrison's Principles of Internal Medicine,
14th ed. New York: McGraw-Hill; 1998:1099.
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