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CoQ10 - Decreased CoQ10 levels in coronary care unit patients associated with inflammation and in-hospital mortality

CoQ10 - Decreased CoQ10 levels in coronary care unit patients associated with inflammation and in-hospital mortality.

On December 9, 2016 in the journal Heart and Vessels, researchers from Japan's Juntendo University School of Medicine reported the finding of a greater risk of inflammation, malnutrition and dying while hospitalized among coronary care unit patients with lower coenzyme Q10 (CoQ10) levels.

The study included 257 men and women with cardiovascular disease admitted to Juntendo University Hospital's coronary care unit (CCU) from April 2012 to January 2013. Diagnoses included ischemic cardiomyopathy, nonischemic cardiomyopathy, acute coronary syndrome, arrhythmia, venous thromboembolism, aortic disease and others. Fasting blood samples collected within 24 hours of admission were analyzed for serum CoQ10, plasma lipids, glucose, C-reactive protein (CRP, a marker of inflammation) and additional factors.

Coenzyme Q10 levels averaged 0.54 milligrams per liter (mg/L) among CCU patients in the current study. (In comparison, a study that measured CoQ10 levels among 146 healthy older individuals in the U.S. found average levels of 0.71 mg/L.) Patients who were treated with statins had CoQ10 levels that averaged 0.46 mg/L, in comparison with an average of 0.58 mg/L among those who were not being treated with the drugs. Lower CoQ10 levels were associated with higher CRP levels, indicating an inflammatory state. Decreased CoQ10 levels were also associated with having a lower body mass index (BMI) which suggested malnutrition.

Within an average of 38 days from the time of admission, 14 deaths occurred among the study's subjects. Serum CoQ10 levels were significantly lower, at an average of 0.43 mg/L, among those who died compared to levels that averaged 0.55 mg/L among survivors.

The authors note that CoQ10's ability to improve cellular bioenergetics contributes to its potential role in heart failure prevention and therapy. It also has antioxidant and vasodilatory effects that can benefit the cardiovascular system.

"To our knowledge, this is the first study to measure CoQ10 levels in patients with varied acute cardiovascular diseases," authors Megumi Shimizu and colleagues announce.

"Numerous studies have demonstrated various beneficial effects of CoQ10 supplementation on cardiovascular disease," they write. "Indeed, CoQ10 supplementation increases cardiac mitochondrial CoQ10 levels to improve cardiac function, and improves endothelial function, which is a critical risk factor for atherosclerotic diseases. Therefore, further prospective studies are warranted to elucidate the effects of CoQ10 supplementation on the prognosis of critical cardiovascular disease in patients admitted to the CCU."

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Heart Disease - Benefits for Heart Disease - Article - Alpha Lipoic Acid

Congestive heart failure (CHF) occurs when the heart cannot pump out enough blood to meet the needs of the body. Any form of heart disease may lead to CHF, which results in a reduced ability to exercise and in severe cases can impair daily function. CHF is the most common cause of death for people over age 65.

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Ubiquinone & Ubiquinol - The Importance of CoQ10: By: Bruce Brightman - LifeSource Vitamins - Article

CoQ10 is an ideal nutrient for all of us. It affects our energy and longevity, heart health, blood pressure, brain, gums, stomach, immune system, and much more. It is an enzyme found in almost all cells in the body, where it helps with the production of energy within the mitochondria. There is evidence that it can increase the volume of oxygen in the blood by as much as 15%.

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Post - CPR Survival - Coenzyme Q10 Increases Survival - COQ10 - Article

Combining coenzyme Q10 (CoQ10) supplementation with hypothermia therapy increases survival and might prevent neurological damage in people who have received CPR (cardiopulmonary resuscitation) after a heart attack, according to Circulation (2004;110:3011-6).

CPR is a technique used to restore the heartbeat and breathing immediately after events such as a heart attack or a major trauma.

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Red Yeast Rice and Lowering Cholesterol. FDA States: - Article By: Bruce Brightman - LifeSource Vitamins

The ruling of the FDA on red yeast rice that, a natural substance found in red-yeast-rice (Cholestin) could not be marketed as a cholesterol owering agent is not correct, since Cholestin is a natural substance. It turns out that this food source supplement contains a naturally occuring component (monacolin K) that the FDA has already allowed to go on the market as a patented drug called Mevacor (lovastatin).

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Strokes & Heart Disease: by Bruce Brightman - LifeSource Vitamins - Article

In past articles, I have mentioned the many health benefits of fish oil and specifically omega-3 fats. This in not "breaking" news since the potential health benefits of omega-3 fats have been discussed for several decades.

Originally, the benefits of omega-3 fats were discovered by accident. It was found that people who had a diet rich in omega-3 fats, primarily as north Atlantic fish, had a much lower incidence ...

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Air Pollution Shown to Increase Heart Disease Risk by: Bruce Brightman - LifeSource Vitamins - Article

Now we may be able to add air pollution to the list of factors of modern life that increase heart disease risk.

For some time, we have known that air pollution can make asthma and other lung diseases, like emphysema, worse. The annual medical cost of air pollution's impact on these diseases is measured in the tens of millions of dollars.

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The All Mighty Blueberry! by Bruce Brightman - LifeSource Vitamins - Article

The health benefits of fruits and vegetables are well-known, especially with respect to cardiovascular disease and certain kinds of cancer. Fruits and vegetables may also have important effects on other body systems and diseases. We wanted to find out if fruits and vegetables could change how age affects brain function. We were particularly interested in the effects on motor function (coordination ...

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Barley - FDA Approves Health Claim for Barley. - Article

People can lower their heart disease risk by eating barley, and the evidence is strong enough that the US Food and Drug Administration (FDA) has announced that this health claim can be printed on the packaging of barley and foods containing barley.

Heart disease remains one of the leading causes of disability and death in the Western world. A healthy lifestyle-including eating a high-fiber low-saturated-fat diet ...

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Improve Heart Health in People with Type 2 Diabetes - Article - Chromium

When people with type 2 diabetes supplement with chromium, an electrocardiogram (ECG) measurement believed to indicate a reduced risk of heart disease improves, according to the American Heart Journal (2005;149:632-6).

Type 2 diabetes (sometimes called adult-onset diabetes) is a chronic disease marked by inability to control blood sugar (glucose) levels.

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Heart Disease Risk - Increasing Magnesium in Diet May Lower Heart Disease Risk - Article

Increasing the amount of magnesium one consumes in the diet may reduce the risk of developing coronary heart disease, according to a new study in The American Journal of Cardiology (2003;92:665-9). Eating foods high in magnesium may lower the likelihood of having a heart attack or stroke.

Heart disease is the number one killer of Americans and affects more than 58 million adults in the ...

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Women and Men - Multivitamin Supplements Prevent Heart Attacks. - Article

Men and women who take a daily multivitamin have fewer heart attacks than those who do not, according to a new study published in the Journal of Nutrition (2003;133:2650-4).

It has long been known that healthful habits are essential to cardiac health. Regular exercise, not smoking, and eating a diet rich in fruits, vegetables, and fiber have all been shown in numerous studies to be effective means for ...

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Reduce Blood Pressure with Omega-3 : Study. - Article - c Reuters 2007.

A diet with liberal servings of fish, nuts and seeds rich in nutrients called omega-3 fatty acids can help lower a person's blood pressure , according to a study released on Monday.

"A large percentage of people between ages 20 and 60 have a rise in blood pressure, and by middle age many have high blood pressure," said Dr. Jeremiah Stamler, professor emeritus of preventive medicine at ...

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Why Omega 3 Is A Must For All Adults: by Bruce Brightman - LifeSource Vitamins - Article

Cancer is less common in communities that eat large amounts of fish, and the reason is thought to be the presence in fish of the long chain omega-3 polyunsaturates. Japanese women, for example, eat a lot of fish, and have a very low rate of breast, (and other) cancer. Men who eat fish frequently have a lower risk of prostate cancer. Stomach and intestinal cancers also appear to be less common in fish eaters.

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Surgery - Bypass - Omega 3 (Fish Oil) Protects Heart after Bypass Surgery. - Article

Taking fish oil before a coronary artery bypass might reduce the damage to heart cells caused by the surgery, according to Prostaglandins, Leukotrienes, and Essential Fatty Acids (2005;72:257-65).

Coronary artery bypass surgery is a major heart surgery performed to improve blood flow to the heart muscle. In order to perform the operation, the surgeons must temporarily block the flow of blood to the heart; ...

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Fish and Fish Oil - Omega 3 Prevent Abnormal Heart Rhythms. - Article

Eating fatty fish, such as salmon, tuna, mackerel, and cod, and supplementing with fish oil both reduce the risk of developing abnormal heart rhythms (arrhythmias), according to two recent studies (Circulation 2004;110:368-73 and Prostaglandins, Leukotrienes, and Essential Fatty Acids 2004;71:153-9).
Ample evidence has already shown that eating fatty fish and supplementing with fish oil can reduce ...

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Vitamin C, Blood Pressure and the American Diet: - Article

Several studies have found significant inverse relationships between blood levels of vitamin C and blood pressure. However, in such studies it has been difficult to determine whether the effect was produced by vitamin C or some other nutrient related to vitamin C. We designed a study to investigate the effect of low vs. normal levels of vitamin C intake. We carefully controlled the foods that participants were ...

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Whey Protein May Cut Metabolic Risk

In this study, WPI (Whey Protein Isolate) supplementation in mice reduced the severity of several biomarkers, including gain in body weight and adiposity, insulin resistance, and fatty liver, read more...

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