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SAM-e - Helps Depression and Moods. By Bruce Brightman - Article
SAM-e - Helps Depression and Moods. By Bruce Brightman - Article


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SAM-e - Helps Depression and Moods

stands for S-adenosyl methionine, a naturally occurring molecule that is widely used in Europe for depression. It is found throughout the body. The liver, adrenal glands, and brain have high concentrations of SAM-e.

Research offers hope to patients who haven’t been helped by traditional antidepressant treatment. Studies suggest that for more than half of depressed patients, antidepressants alone don’t eliminate symptoms. That is why taking SAM-e in addition to antidepressants show a marked improvement. SAM-e should not be taken in combination with a prescription antidepressant without the monitoring of a health professional. Other studies have shown that using SAM-e alone can benefit many patients.

is an important methyl donor, an essential step in the synthesis of several neurotransmitters from amino acids in the diet . The antidepressant effects of SAM-e are probably related to multiple mechanisms of action including increased brain levels of serotonin, dopamine , and norepinephrine.

The standard maintenance regimen of oral SAM-e for depressed mood is between 800 and 1600 mg per day in two to four divided doses. A common dosing strategy is to start SAM-e at a dose of 200 mg twice daily, and gradually increase to 400 mg twice daily, monitoring for side effects and therapeutic response. Absorption is improved when SAM-e is taken on an empty stomach (i.e., before meals).

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