- The difference between
ubiquinone and ubiquinol
- New case study on ubiquinol
CoQ10 is an
ideal nutrient for all of us. It affects our energy and longevity, heart
health, blood pressure, brain, gums, stomach, immune system, and much more. It
is an enzyme found in almost all cells in the body, where it helps with the
production of energy within the mitochondria. There is evidence that it can
increase the volume of oxygen in the blood by as much as 15%.
Our cells require CoQ10 to function properly and without it, the cells perish.
It is a strong anti-oxidant in both mitochondria and lipid membranes. CoQ10 is
located exactly where the free-radicals are generated (in the mitochondria)
during the oxidation of nutrients and the production of ATP, making it an
important factor in slowing the aging process.
CoQ10 was discovered in 1957 at the University of Wisconsin-Madison Enzyme
Institute by Fred L. Crane and colleagues. Since 1960, universities and
researchers have published over 1,600 articles in medical journals
demonstrating CoQ10's benefits and importance. In 1978, Peter D. Mitchell won
the Nobel Prize for Chemistry for his discovery of the significance of CoQ10 in
The organs with the highest CoQ10 concentration are the heart, lungs and liver.
Ninety-five percent of our body's energy requirements require the aid of CoQ10.
CoQ10 is heavily concentrated in the heart where it benefits cardiovascular
function (see the case study below). CoQ10 has been an aid to people with high
blood pressure, peptic ulcers, periodontal disease, migraine headaches, muscular
dystrophy, and of course heart disease. CoQ10 also aids in slowing down the
aging process, stimulating the immune system and protecting brain cells. As we
age, the dopamine production within the brain decreases, impairing our memories
major benefits of CoQ10 and its importance to general health.
comes in two forms: ubiquinone and ubiquinol. Ubiquinone is the product most familiar to everyone since it
has been available in the marketplace for a long time and research has shown
is converted within our body into ubiquinol, the potent anti-oxidant portion of
CoQ10. However, as we age, our ability to make this conversion reduces
significantly. Therein lies the major difference between the two products.
Ubiquinol is already in its reduced form as a potent anti-oxidant. Ubiquinol
inhibits protein and lipid oxidation in cell membranes, and helps to minimize
oxidative injury to DNA. So what significance does this have for us? Here is a
recent case study received by Kaneka, the manufacturer of natural pharmaceutical
grade ubiquinol and ubiquinone:
A 65-year old gentleman with advanced ischemic cardiomyopathy was on maximal
medical therapy. In June of 2006, he had low heart function and was receiving
450mg of a soybean oil-based CoQ10 that revealed a level that was sub-therapeutic.
He was then given the ubiquinol formulation at exactly the same dosage of 450mg
per day. Three months later, in September of 2006, his CoQ10 level had
increased dramatically. Further tests one month later showed a dramatic
improvement in heart function and he no longer required any diuretics. By
January of 2007, his improvement was great enough that he became quite active
and required no further hospitalizations. The case study ended with the
physician stating: "This single case represents very striking improvement
that I have not seen before in 25 years of cardiology practice...We have now
repeated and are continuing to treat several other patients with end-stage or
far advanced congestive heart failure with similar remarkable findings."
This study demonstrates the importance of using ubiquinol, especially as we
age. Keep in mind there is every indication that the ubiquinone form has
benefits other than those of ubiquinol. To take full advantage of the benefits
of CoQ10, the dosage should include both forms and then according to age as to
which one you take the most. Also, as demonstrated, ubiquinol does not require
the high amount needed by ubiquinone to gain the same therapeutic effect for
CoQ10 is very safe for healthy individuals. However, if you are on diabetic
medications, diuretics, insulin, ACE inhibitors, Beta Blockers, calcium channel
blockers, HMG Co-A Reductase Inhibitors, Anticoagulants, or Dopamine-enhancing
drugs, check with your doctor. CoQ10's benefits may require changing dosages of
these drugs. Also, check with your health care provider if you are pregnant or
you are giving this to a child.
CoQ10 levels can also be reduced by other nutrients, such as high amounts of
fish oil or pharmaceutical statins. You should check with your health care
provider regarding the dosage. It could go as high as 2,000mg of ubiquinone or
a smaller amount of ubiquinol. A standard dosage appears to be recommended in
the literature as 200mg. My suggestion is to take 100mg of ubiquinone and 100mg
of ubiquinol to gain the benefits of both. An article published in January,
2007 in the journal CNS Spectrums by Dr. Young from Duke University suggested
that safe levels of CoQ10 are between 300mg to 2,400mg a day.
In just 50 years we've learned so much about this amazing nutrient. Just think
how much there is yet to discover in this remarkable field of nutrition.
Brightman - founder