MSM (Methylsulphonylmethane) is a natural form of organic
sulfur found in all living organisms. This natural compound, researched since
1979, provides the chemical links needed to form and maintain numerous
different types of tissues found in the human body, including connective tissue
such as articular cartilage. While MSM is a natural component of almost all
fresh fruits, vegetables, seafood and meat, food-processing methods reduce
sulfur levels, making supplementation more important than ever. LifeSource’s
MSM is tested to meet a minimum 99.7% purity.
What is MSM?
Methyl-sulfonyl-methane (MSM) is a naturally occurring sulfur compound found in
our bodies as well as in many common beverages and foods, including milk,
coffee, tea and green vegetables. In its purified chemical form, it is an
odorless, essentially tasteless, white, water-soluble crystalline solid. It is
one of the safest substances in biology, similar in toxicity to water.
• MSM contains 34% elemental sulfur, by weight.
• MSM is a non-animal-based nutritional supplement and is an all-natural source
Naturally-occurring sulfur, such as that found in MSM, is not
similar to inorganic sulfides, sulfites and sulfates to which many people are
allergic. In other words, people who are allergic to sulfa drugs will not
normally react to MSM or dietary sulfur.
MSM is an organic form of sulfur found in all living organisms. It is the
fourth most abundant mineral in the human body (tenth most abundant in the
known universe) and is found in every cell. Sulfur provides the chemical links
needed to create collagen, which forms and holds the molecular structure of
connective tissue. It forms the disulfide bonds in connective tissue that are
the links in the glycosaminoglycan chains that form cartilage. MSM is an
essential nutrient, not only for connective tissue, but also for all other
tissues in the human body. Unfortunately, modern food-processing methods
greatly reduce natural MSM levels in foods, so very little is obtained from the
diet these days, unless your diet is rich in unprocessed milk, vegetables and
grains. Sulfur is abundant in chondroitin sulfate and hyaluronic acid, two
constituents that support healthy joint function.
List of Common Uses for Nutritional Sulfur (MSM)
Acne • Alertness • Allergies (Dust, Food, Mites, Pollen) •
Anti-aging • Asthma • Athletic injuries/pain • Back pain • Blood clotting •
Candida • Carpal Tunnel Syndrome • Circulatory problems • Concentration •
Conjunctivitis • Constipation • Dental pain • Depression • Diabetes • Diarrhea
• Emphysema • Enhances Vitamin C • Fibromyalgia • Flexibility • Free radical
damage • Gastrointestinal problems • Hair growth and appearance • Healing burns
• Heartburn/hyperacidity • Hypertension • Immune function • Infection •
Inflammation • Insulin balance • Interstitial Cystitis • Itching • Joint pain •
Leg cramps • Lung dysfunction • Memory loss • Migraines • Muscle pain • Nails
(growth, strength) • Nerve disorders • Pain • Parasites • Pets (silky coat/skin
disorders) • Rashes • Reduce wrinkles • Removes toxins • Rheumatism •
Rheumatoid arthritis • Scar tissue • Scleroderma • Sinusitis • Skin disorders •
Skin (health and appearance) • Stress • Tendonitis • TMJ • Tumor growth •
Urinary tract disorders • Wound healing • Yeast infections
Among its benefits, MSM:
• May replace expensive drugs/nutrients to treat arthritis, gastric
• Helps remove excess mercury from the body and maintains health of skin, hair,
* LifeSource Vitamins' MSM is a must for anyone suffering
with any of the above mentioned ailments.
|Serving Size: 2 capsules
|Amount Per Serving: 2000 mg.
|Servings per Container: 60
Usage and Toxicity
Due to its positive effects maintaining healthy cell
formation, 2000 mg to 6000 mg of supplemental MSM daily is recommended. Of
course, the optimum daily dosage of MSM depends largely on body size, age and
the nature and severity of any deficiency symptoms you may be experiencing.
Since vitamin C provides a positive synergistic it should be taken along with
MSM ranks in the "extremely low" toxicity category
with a toxicity profile similar to that of water. When oral supplements are
taken, the body will distribute MSM where it is needed. After about 12 hours,
any excess amounts will be flushed out of the body. MSM is a member of the
sulfur family, should never be confused with sulfa drugs to which some people
MSM should be supplemented with vitamin C to aid the
production of connective tissue (elastin and collagen).
10.01.04 -- MSM: Helping Alleviate Allergy Symptoms
By Greg Arnold, July 14, 2004, Abstracted from “A
multicentered, open-label trial on the safety and efficacy of
methylsulfonylmethane in the treatment of seasonal allergic rhinitis” in the
Journal of Alternative and Complementary Medicine 2002; 8(2): 167-73
Seasonal allergic rhinitis (SAR), a common clinical expression of an atopic
reaction (genetic predisposition) to inhaled allergens, affects more than 23
million Americans annually. These allergic reactions can range from mild daily
symptoms to debilitating headaches, severe nasal congestion that may lead to
sinus infection and difficulties breathing.
Current prescription and over-the-counter medications act mainly by inhibiting
histamine, the primary inflammatory mediator in allergic reactions.
Unfortunately, patients taking these medications experience symptoms that
include sedation, dizziness, rings in the ears, fatigue, insomnia, tremors,
nausea, constipation, and diarrhea.1 The cornucopia of side effects has spawned
a search for alternative therapies that will give similar results without the
side effects. One such supplement showing promise is methylsulfonylmethane
Researchers had 50 subjects consume 2600 mg of MSM orally per day for 30 days.
The subjects were evaluated using a Seasonal Allergy Symptom Questionnaire
(SASQ) at 0, 7, 14, 21, and 30 days. Researchers also measured C-reactive
protein and immunoglobulin at the beginning and end of the study.
Results were observed as early as day 7, where upper and total respiratory
symptoms were reduced significantly when compared with the beginning of the
study. By week 2, energy levels had “increased significantly.” By week 3, lower
respiratory symptoms were significantly improved. Even more encouraging was
that all improvements observed in the subjects were maintained.
Not only did the researchers recommend MSM for allergies (2600 mg/day for 30
days), they observed that “few side effects are associated with the use of this
1 Hardman JG. Goodman & Gilman’s The Pharmacological Basis of Therapeutics.
9th ed. New York, McGraw-Hill, 1996
02.02.06--MSM Alleviates Arthritis Pain
Healthnotes Newswire (February 2, 2006)—Methylsulfonylmethane
(MSM), a naturally occurring sulfur-containing compound, may help decrease
joint pain and improve physical functioning in people with osteoarthritis (OA)
of the knee, reports Osteoarthritis and Cartilage (2005 Nov 22 [E-pub ahead of
By Kimberly Beauchamp, ND
OA is a chronic, degenerative disease of the cartilage that lines and cushions
the joints. It is more common in people over age 45. Although any joint may be
affected, OA most frequently develops in the hips, knees, spine, and feet. When
OA affects the knee joint, the progressive loss of cartilage can be seen on an
x-ray as a narrowed space between the bones that surround the joint. Bits of
damaged cartilage may also break off and enter the joint space, limiting motion
and causing considerable pain. Risk factors for OA development include having a
family history of the disease, being overweight, and overusing or having a
previous injury of a joint.
Acetaminophen (Tylenol) and nonsteroidal anti-inflammatory medications (NSAIDs)
such as ibuprofen (Advil) may be used to decrease the pain associated with OA.
Sometimes corticosteroid injections are given directly into the joint to
decrease swelling. Unfortunately, these treatments do not slow the disease
progression. In addition, corticosteroid injections may cause more thinning of
the cartilage and damage the tendons surrounding the joint, and long-term use
of NSAIDs increases the chance of developing gastric ulcers. For these reasons,
safer alternatives to these medications are being sought.
MSM is a popular remedy for OA pain that is often found in supplements also
containing glucosamine sulfate and chondroitin sulfate. A recent study found
that glucosamine and chondroitin alleviate OA pain at least as well as the
prescription medication Celebrex. Previous trials suggest that MSM may decrease
inflammation and help repair connective tissue (such as cartilage), but there
is little research on its usefulness for treating OA.
In the new study, 40 men and women between ages 40 and 76 with OA of the knee
were given either 6 grams of MSM per day for 12 weeks or a placebo. The people
rated their level of pain, stiffness, physical functioning (ability to get
around and perform daily activities), and overall symptoms before the study and
after 2, 4, 8, and 12 weeks. The people and their physicians also gave their
overall impression of the state of their arthritis before and after the study
and also rated their response to treatment. Blood and urine tests were
performed to assess the safety of MSM and to investigate the possible ways it
works in the body.
The level of pain decreased significantly and physical functioning improved
after 12 weeks in the MSM group compared with the placebo group. Changes in
stiffness and overall symptoms were similar in the two groups, and there were
no differences between the groups in overall response to treatment.
MSM did not appear to raise blood pressure, nor did it adversely affect
cholesterol levels, blood clotting, or measures of kidney, nervous-system,
liver, or blood-cell health. Side effects were generally mild and were similar
between the two groups.
The results of this investigation suggest that MSM may be a useful adjunct in
the treatment of OA.
Kimberly Beauchamp, ND, earned her bachelor’s degree from the University of
Rhode Island and her Doctorate of Naturopathic Medicine from Bastyr University
in Kenmore, WA. She cofounded South County Naturopaths in Wakefield, RI. Dr.
Beauchamp practices as a birth doula and lectures on topics including
whole-foods nutrition, detoxification, and women’s health.
02.24.06 -- MSM Found to Provide Short-Term Relief for Arthritic Knee Pain
By Greg Arnold, DC, CSCS, February 15, 2006, abstracted from
“Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a
pilot clinical trial” published online in Osteoarthritis and Cartilage
As the leading cause of disability in the U.S., Osteoarthritis (OA) limits the
everyday activities of more than 7 million Americans1 and can be associated
with significant restrictions on quality of life.2 As a result, a number of
options are available for patients to help control their arthritis pain,
including conservative measures like over-the-counter medications such as
aspirin and ibuprofen(3,4) and more drastic measures like surgery.5 Even the
use of complementary and alternative medicine (CAM) has increased over the
years to help treat OA.6
When it comes to nutritional supplementation in the treatment of OA, three such
supplements receiving attention are glucosamine, chondroitin, and methylsulfonylmethane
(MSM). Glucosamine and chondroitin sulfate can help both prevent and treat OA7
by reducing inflammation, stimulating the synthesis of proteoglycans and
hyaluronic acid and reducing the synthesis of nitric oxide and cell death of
MSM has undergone numerous trials in the treatment of OA(11,12,13) and as a
result, has become an extremely popular supplement for arthritic and rheumatic
pain. In 2003 alone, the retail sales of MSM as a single ingredient were $115
million.14 Now a new study15 has found that MSM can help provide short-term
pain relief for OA in the knee.
In the study, 50 men and women aged 40–76 years with knee OA pain took either
MSM 3 g or placebo twice a day for 12 weeks (6 g per day total). To measure
outcomes, researchers used the Western Ontario and McMaster University
Osteoarthritis Index visual analogue scale (WOMAC), patient and physician
global assessments (disease status, response to therapy), and SF-36 (overall
health-related quality of life).
They found that compared to placebo, MSM produced “significant decreases” in
WOMAC pain and physical function impairment with no notable changes in WOMAC
stiffness and total symptoms scores. MSM also produced “improvement” in
performing activities of daily living when compared to placebo on the SF-36
While concluding that “MSM (3 g twice a day) improved symptoms of pain and
physical function during the short intervention without major adverse events,”
they admit that long-term effects on pain relief “could not be confirmed” but
should be investigated.
MSM Provides Arthritis Relief
Good news for people who suffer from muscle and joint pain,
interstitial cystitis, scleroderma, or allergies: Methylsulfonyl-methane, or
MSM, is a nutrient effective in alleviating the numerous debilitating symptoms
caused by each of these ailments. MSM is an extraordinary new dietary
supplement that is amazing users and researches alike because of its remarkable
benefits. Completely natural, MSM has vitamin-like effects that promote normal
growth and repair damaged mechanisms in the body.
MSM is extremely important to human beings because it provides a unique dietary
source of sulfur that we must have in order to function. MSM is a special
biological sulfur, 34% sulfur by weight, found in all plants, soils, fruits,
vegetables, and meats. According to Dr. Stanley W. Jacobs, M.D., from the
Oregon Health Sciences University in Portland, "MSM provides a good
portion of the body's need for sulfur. Sulfur is an important building
block." In fact, Dr. Jacob's comment might be an understatement. Sulfur,
one of the most abundant minerals in the body, is a component of amino acids,
vitamins, hormones, coenzymes, and antioxidants. Because sulfur is necessary to
build "disulfide bonds", it forms part of the body's physical
structure, including protein, collagen, glucosamine, skin, and nails.
One of the strongest effects of MSM is its ability to relieve muscle pain
through the reduction of inflammation. People who suffer from sore joints or
arthritis benefit greatly from MSM because many of the components of joints are
made from collagen and glucosamine, which are both sulfur-dependent. People
with arthritis report substantial and long-lasting relief while supplementing
MSM in their diet in daily amounts ranging from 100 to 5,000 mg The beneficial
effect is due in part to the ability of MSM to sustain cell flow-through,
allowing harmful substances to flow out while permitting nutrients to flow in,
and thereby preventing pressure buildup in cells that causes inflammation in
the joints and elsewhere, and translates to pain. MSM, by equalizing cell
pressure, treats the cause of inflammation, unlike an aspirin that would treat
the symptom by shutting off the nerve.
The sulfuric content of MSM is also effective in combating various other health
problems. The anti-inflammation effect of the nutrient relieves the painful
bladder irritation of interstitial cystitis. MSM often works in easing the
symptoms of scleroderma and allergies as well. MSM is an effective tool for
preventing the everyday aches and pains common in people who suffer from
arthritis and from symptoms that can become debilitating if left untreated.
Jacobs calls it "... an important nutritional supplement. MSM is safe and
useful." More ailments eased by MSM include gastro-intestinal problems,
acid stomach, and lung problems.
Because it is needed to form crucial blood proteins and amino
acids, the sulfur in MSM is essential to everyday living. Without proper levels
of MSM, our bodies are unable to build good, healthy cells, making them prone
to illness. When there is sufficient MSM in your system, your cells become more
permeable, enabling your body to quickly flush out any undesirable foreign
particles. If your body is sulfur deficient, the cell walls become hard and
stiff, hindering the flow of fluid through the cell walls.
Here are some of the symptoms of MSM deficiency
1. Arthritis Conditions
2. Damage of the skin
4. Scar tissue
7. Sore muscles
9. Candida Infections 9 (albacans)
11. High Cholesterol
14. Joint, back, dental pain
15. Systemic inflammation
*This statement has not been evaluated by the FDA. This
product is not intended to diagnose, treat, cure or prevent any disease. As
always, consult with your physician before taking any and all supplements.